Authors: Imran Shahid, Qaiser Jabeen

Hepatitis C Virus-Host Interactions and Therapeutics: Current Insights and Future Perspectives

eBook: US $89 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $98
Library License: US $356
ISBN: 978-981-5123-44-9 (Print)
ISBN: 978-981-5123-43-2 (Online)
Year of Publication: 2023
DOI: 10.2174/97898151234321230101

Introduction

The burden of hepatitis C virus infection on the public health care system continues to remain significant despite the remarkable progresses made in HCV therapeutics in the recent past. There are now almost a dozen oral interferon-free direct-acting antivirals available for the treatment of hepatitis C virus infection. Despite advances in the treatment of HCV, therapeutic gaps remain that are yet to be fully explored, researchers and scientists still strive to understand virus-host interactions to map the disease’s progression; extrahepatic manifestations and virus invasion strategies impacting the host’s immune system. This book briefly discusses the biology of HCV infection, virus-host interactions, molecular epidemiology of the infection, and the full spectrum of immune responses to hepatitis C. It also provides in-depth information about HCV, clinical diagnostics, and therapeutic knowledge to all stakeholders involved in HCV screening, diagnosis, treatment, and management.

Topics covered in chapters include

1) HCV-host interactions leading to asymptomatic acute infection.

2) The progression of acute HCV infection to chronic disease and subsequent extrahepatic comorbidities.

3) Innate and adaptive immune responses in HCV infections.

4) Consensus-based Approaches for Hepatitis C Screening and Diagnosis.

5) Advances in hepatitis C therapy and global management of HCV.

6) The outcomes of Oral Interferon-free Direct-acting Antivirals as Combination Therapies to Cure Hepatitis C.

This book would be a valuable addition to undergraduate and postgraduate hepatology students and physicians, clinicians, hepatologists, and health care officials involved in HCV clinical diagnosis and therapeutics.

Foreword

- Pp. i
Sajida Hassan
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Preface

- Pp. ii-iii (2)
Imran Shahid, Qaiser Jabeen
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Dedication

- Pp. iv

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HCV-Host Interactions: A Plethora of Genes and their Intricate Interplay Part 1: Virus Specific Factors

- Pp. 1-25 (25)
Imran Shahid, Qaiser Jabeen
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HCV-Host Interactions: Interplay Part 2: Host Related Determinants and Intracellular Signaling

- Pp. 26-53 (28)
Imran Shahid, Qaiser Jabeen
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Immune Responses and Immunopathology of Acute and Chronic Hepatitis C Virus Infection

- Pp. 54-71 (18)
Imran Shahid, Qaiser Jabeen
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Consensus-based Approaches for Hepatitis C Screening and Diagnosis in General and Vulnerable Populations

- Pp. 72-111 (40)
Imran Shahid, Qaiser Jabeen
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The Current Paradigms of Hepatitis C Diagnosis and Innovations in the Pipeline

- Pp. 112-141 (30)
Imran Shahid, Qaiser Jabeen
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Current Landscape of HCV Therapeutics

- Pp. 142-174 (33)
Imran Shahid, Qaiser Jabeen
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Consensus Treatment Guidelines and Recommendations to Treat Hepatitis-C Infected Populations

- Pp. 175-202 (28)
Imran Shahid, Qaiser Jabeen
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Treatment Recommendations for Harder-to-Cure and Vulnerable Populations

- Pp. 203-230 (28)
Imran Shahid, Qaiser Jabeen
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Real-World Therapeutic Outcomes of Direct-Acting Antiviral Regimens and Formidable Challenges

- Pp. 231-289 (59)
Imran Shahid, Qaiser Jabeen
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Appling Drug Discovery in HCV-therapeutics: A snapshot from the past and glimpse into the future

- Pp. 290-342 (53)
Imran Shahid, Qaiser Jabeen
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Global Health Sector Strategy (2016-2021) Toward Ending Hepatitis-C: Promises, Policies, and Progress

- Pp. 343-369 (27)
Imran Shahid, Qaiser Jabeen
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WHO Hepatitis C Elimination Goal by 2030: Feasible or not?

- Pp. 370-405 (36)
Imran Shahid, Qaiser Jabeen
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Appendices

- Pp. 406-424 (19)
Imran Shahid, Qaiser Jabeen
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Subject Index

- Pp. 425-430 (6)
Imran Shahid, Qaiser Jabeen
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