Preface

In the 21st century, the current scenario of breast cancer was nightmarish and has greatly threatened millions across the world. Triple negative breast cancer, the most aggressive form of breast cancer has horrified people and seemed to kill the individuals with frightening certainty. Poor clinic-pathological attributes, prognostic markers, unavailability of efficient therapeutic approaches, higher chances of disease relapse along with metastasis to distant sites have worsened the clinical outcome of the disease. Prevalence and epidemiology trends of TNBC patients have induced a global catastrophic risk. This lucid work entitled ‘Therapeutic Drug Targets and Phytomedicine For Triple Negative Breast Cancer’ is an attempt to rapidly disseminate to oncologists and other members of the scientific community regarding updates of TNBC. The present work examines TNBC from basic definition to stratification of subtypes, genetic and transcriptional profiling, cellular and molecular diagnostic approaches, molecular signaling pathways involved in complications, preclinical and clinical evidence of conventional therapeutic regimens along with unveiling efficacy of herbal medicines to combat complications of TNBC. The present book deals with detailed etiological insights of TNBC including diverse subtypes, and practical information will help clinicians engaged in the determination of molecular and pathological cognizance of disease. Genetic, transcriptional, and clinical heterogeneity of disease has been discussed from multidisciplinary perspectives. The molecular complexity of signaling pathways and prognostic markers would help in the identification of therapeutic vulnerabilities. A paradigm of the therapeutic approach along with completed, ongoing, and terminated clinical trials were discussed to analyze overall survival, disease free survival, and distant metastasis free survival in TNBC patients. The impact of tumor microenvironment in facilitating the escape of TNBC cells from chemotherapeutic and immunological response were also highlighted. To combat drug resistance and efficacy issues, the potential role of natural moieties as dynamic, promising, and new therapeutic strategies to benefit TNBC patients was foreground. Druggability parameters of these phytochemicals including bioavailability, bio-absorption were discussed and nanosoldiers have been introduced to enhance their pharmacokinetic profile, distribution, and release rate. Combinational therapies comprising of conventional and herbal medicine approach to completely abolish complications of TNBC including their regulatory issues and potential role of herbal medicine in rejuvenating the health of affected individuals were uncovered. The present compendium will be of great interest to oncologists, clinicians, researchers, students, and the pharmaceutical sector to gain further insights into TNBC and to identify the potential role of herbal medicine in tackling the disease.