Flavonoids and Phenolics

Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.

This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.

Each chapter follows a specific format for a phytochemical agent with common chemical features:

- General background on the (phyto)chemistry of the scaffold

- General background on the pharmacological profile of the scaffold

- A Description of the proposed derivatives and their advantages with respect to the parent compounds (emphasizing the synthetic approaches and structure-activity relationships)

- In silico analysis of the crucial interactions with the biological target

- Clinical studies and patent survey (if available) on the new and proposed structures

The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.

Audience

Academic and professional researchers and clinicians in the field of medicinel chemistry and pharmaceutical chemistry.

Editor(s):

Simone Carradori
Department of Pharmacy, G. d’Annunzio
University of Chieti-Pescara
Italy

Contributor(s):

Alessandra Ammazzalorso
Department of Pharmacy, Medicinal Chemistry Unit
G. d’Annunzio University of Chieti-Pescara
Via dei Vestini, 66100 Chieti
Italy

Alessandro Bonardi
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences
Pharmaceutical and Nutraceutical Section, University of Florence, Via U
Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy

Alessio Nocentini
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences
Pharmaceutical and Nutraceutical Section, University of Florence, Via U
Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy

Antonella Capperucci
Department of Chemistry “Ugo Schiff”
University of Florence
Via della Lastruccia 13, I-50019 Sesto Fiorentino
Italy

Arafa Musa
Department of Pharmacognosy
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia

Atilla Akdemir
Computer-aided Drug Discovery Laboratory, Department of Pharmacology, Faculty of Pharmacy
Bezmialem Vakif University
Fatih, Istanbul 34093
Turkey

Barbara De Filippis
Department of Pharmacy
“G. d’Annunzio” University of Chieti-Pescara
Via dei Vestini 31, 66100 Chieti
Italy

Bijo Mathew
Department of Pharmaceutical Chemistry
Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus
Kochi-682 041
India

Celeste De Monte
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy

Claudio Ferrante
Department of Pharmacy, Medicinal Plant Unit (MPU), Botanic Garden Giardino dei Semplici
G. d’Annunzio University of Chieti-Pescara
Via dei Vestini, 66100 Chieti
Italy

Claudiu T. Supuran
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Pharmaceutical and Nutraceutical Section
University of Florence
Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy

Cristina Scarpecci
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy

Damiano Tanini
Department of Chemistry “Ugo Schiff”
University of Florence
Via della Lastruccia 13, I-50019 Sesto Fiorentino
Italy

Della Grace Thomas Parambi
Department of Pharmaceutical Chemistry
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia

Federico Appetecchia
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy

Federico De Paolis
Department of Physiology and Pharmacology “V. Ersparmer”
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy

Francesco Cairone
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy

Giovanna Poce
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy

Heiko Lange
Department of Environmental and Earth Sciences
University of Milano-Bicocca
Milan
Italy

Leena K Pappachen
Department of Pharmaceutical Chemistry
Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus
Kochi-682 041
India

Luc Zongo
Department of Pharmacy
University of Saint Dominic of West Africa (USDAO)
Doulougou
Burkina Faso

Mohamed A. Abdelgawad
Department of Pharmaceutical Chemistry
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia

Manoj Kumar Sachidanandan
Department of Oral and maxillofacial surgery and diagnostics
College of Dentistry, Hail University
Hail Province, 2440
Saudi Arabia

Maria Antonietta Casadei
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy

Melissa D’Ascenzio
D’Arcy Thompson Unit, Biological and Biomedical Sciences Education
School of Life Sciences, University of Dundee
DD1 4HN, Dundee
UK

Mutairah Shaker Alshammari
Department of Pharmaceutical Analytical Chemistry, Faculty of science
Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia

Paolo Guglielmi
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy

Rania Bakr
Department of Pharmaceutical Chemistry
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia

Sara Consalvi
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy

Stefania Cesa
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy

Stefania Garzoli
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy

Stefania Petralito
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy

Trond Vidar Hansen
Department of Pharmacy
Section for Pharmaceutical Chemistry, University of Oslo
PO Box 1068 Blindern, N-0316 Oslo
Norway

Virginia Pontecorvi
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy

Vaishnav Bhaskar
Department of Pharmaceutical Chemistry
Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus
Kochi-682 041
India

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