Editors: Surya Pratap Singh, Hagera Dilnashin, Hareram Birla, Chetan Keswani

Indopathy for Neuroprotection: Recent Advances

eBook: US $89 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $98
Library License: US $356
ISBN: 978-981-5050-87-5 (Print)
ISBN: 978-981-5050-86-8 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150508681220101

Introduction

Degenerative nerve diseases are age-related, progressive and cause irreversible neurological loss that may lead to death. Chronic diseases like amyotrophic lateral sclerosis, Huntington’s disease, Alzheimer’s disease, and Parkinson’s disease are associated with insoluble protein depositions and pose serious health challenges that may intensify in the coming decades. Current therapies only help to alleviate some of the physical or mental symptoms associated with neurodegenerative diseases, although there is currently no remedy for slow disease progression. In recent years, attempts have been made to discover a mechanism for neurodegenerative diseases and prospective treatment that may help mitigate aging effects and prevent these diseases. Natural products have been a constant source of new approaches for the treatment of neurodegenerative diseases, in particular plant alkaloids and polyphenolic compounds.

Indopathy for Neuroprotection: Recent Advances highlights herbal treatments that are preferred over conventional treatments in some regions. Book chapters focus on the effects of various medicinal plants that have shown promise in reversing pathological symptoms of neurodegenerative disease and highlight the neuroprotective role of medicinal herbal phytochemicals and their mechanism of action. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.

Preface

With the rapid increase in life expectancy and the proportion of the elderly population, the global prevalence of various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease, is rising dramatically. The demographic trend of the aged population has attracted people's attention to the discovery and treatment of new drugs for age-related diseases. Currently, there are various drugs and treatments available for the treatment of neurodegenerative diseases, but side effects or insufficient drug efficacy have been reported. With a long history of herbs or natural compounds used in the treatment of age-related diseases, new evidence has been reported to support the pharmacological effects of Indopathy in ameliorating symptoms or interfering with the pathogenesis of neurodegenerative diseases.

Many indian medicinal plants have been used for thousands of years in indopathy. Amongst these are plants used for the management of neurodegenerative diseases, such as Parkinson's, Alzheimer's, loss of memory, degeneration of nerves, and other neuronal disorders by Ayurvedic practitioners. Though the etiology of neurodegenerative diseases remains enigmatic, there is evidence indicating that defective energy metabolism, excitotoxicity, and oxidative damage may be crucial factors.

This book summarizes the new therapeutic leads from herbal sources for various types of neurodegenerative diseases. Based on recent research, this book makes an effort to utilize existing knowledge of some popular medicinal plants, and their biologically active components have been discussed, especially those used in indopathy. Several promising plants such as Withania somnifera, Bacopa monnieri, Centella asiatica , and Mucuna pruriens are worth exploring for the development of neuroprotective drugs.


Surya Pratap Singh
Department of Biochemistry
Institute of Science, Banaras Hindu University
Varanasi-221005, India

Hagera Dilnashin
Department of Biochemistry
Institute of Science, Banaras Hindu University
Varanasi-221005
India
Hareram Birla
Department of Biochemistry
Institute of Science, Banaras Hindu University
Varanasi-221005
India
&

Chetan Keswani
Department of Biochemistry
Institute of Science, Banaras Hindu University
Varanasi-221005, India

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