Authors: V. V. Sathibabu Uddandrao, Parim Brahma Naidu

Advancements in Cardiovascular Research and Therapeutics: Molecular and Nutraceutical Perspectives

eBook: US $59 Special Offer (PDF + Printed Copy): US $94
Printed Copy: US $65
Library License: US $236
ISBN: 978-981-5050-84-4 (Print)
ISBN: 978-981-5050-83-7 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150508371220101


This reference summarizes recent advancements in knowledge about cardiovascular disease and pharmacology. The goal of the book is to inform readers about recent findings on cardiovascular therapeutics and how to conduct experiments to evaluate natural products. It presents 10 chapters that cover basic clinical research on cardiovascular diseases and therapeutic agents derived from natural sources. The book concludes with a series of experiments that demonstrate the methods to test the ameliorative effects of 3 phytochemicals: Biochanin A (red clover), Zingiberene (ginger oil) and Betaine (sugar beet).

Key Features:

- 10 chapters that highlight recent research cardiovascular medicine and pharmacology

- Covers knowledge about basic cardiovascular physiology, congestive heart failure treatment and the treatment of heart inflammation.

- Covers uses, benefits, and drawbacks of numerous rodent and non-rodent animal models for studying CVD

- Updates readers about 21st-century CRISPR-cas9 technology and its uses in CVD.

- Covers the significance of Indian Ayurvedic techniques on the cardiovascular system,

- Covers information about nutraceuticals for CVD therapy

- Includes experiments to evaluate 3 phytochemicals for the treatment of different heart diseases such as hypertension, obesity-cardiomyopathy and the mitigation of inflammatory cytokines in myocardial infarction.

This book is an informative resource for cardiologists, and researchers working in the field of cardiovascular pharmacology. It also helps readers to understand the benefits of herbal medications that are commonly available for consumption in homes.


Cardiovascular diseases (CVD) belong to the most severe health problems and are considered the main cause of morbidity and mortality in modern society. CVDs consist of a broad spectrum of diseases, including atherosclerosis, hypertension, myocardial ischemia, cardiomyopathy, and heart failure. Risk factors for CVDs include hypertension, hyperlipidemia, obesity, diabetes mellitus, metabolic syndrome, and a sedentary lifestyle. Therapeutic effects against CVD have been demonstrated by several medicinal plants and nutraceuticals thus presenting new possibilities for the treatment of CVD risk. Evidence suggests that this approach is very promising. So, the aim of this book is to present an update on the most recent evidence related to the use of nutraceuticals in the context of the prevention and treatment of CVD.

Chapter 1 discusses CVD and nutraceuticals and the underlying mechanism and therapeutic biomarkers. The chapter presents the beneficial effects of nutraceuticals on the heart and also gives an insight into the bioinformatics approach to identify novel therapeutic biomarkers in order to update the practitioner's awareness of the use of nutraceuticals for CVD management. Chapter 2 provides detail about congestive heart failure and insight into pharmacotherapy. This chapter explains possible pharmaceutical approaches to treat congestive heart failure. Chapter 3 provides a review of diet, inflammation, and CVDs. The chapter reveals the role of diet in the prevention of vascular inflammation and the usefulness of antioxidants in preventing CVD. Chapter 4 represents the applications, advantages and disadvantages of various rodent and non-rodent animal models in the research on CVD especially while evaluating nutraceuticals’ effects against CVD. On the other hand, chapter 5 discusses the CRISPR-cas9 technologies in the 21st century and their applications in cardiovascular diseases.

Chapter 6 discloses the role of Indian Ayurvedic approaches to the cardiovascular system, etiopathogenesis, and therapeutic strategies. The chapter highlights the precipitants that attenuate Vyana Vayu and addresses curative measures to restore Vyana Vayu. Chapter 7 depicts nutraceuticals as potential agents to rescue the human race from CVD. The chapter point outs the current scenario of CVD, pathophysiology, therapeutic drugs available, the role of nutraceuticals in treating CVD, and their mode of action with a special emphasis on commonly used kitchen spices. Chapter 8 explains the therapeutic potential and mode of action of Biochanin-A, a natural compound predominantly found in soy, chickpea, peanuts, alfalfa sprouts, and red clover against hypertension in experimental rats. Chapter 9 concentrates on the ameliorative potential of Zingiberene, a monocyclic sesquiterpene that is the principal constituent of ginger (Zingiber officinale) against obesity and cardiomyopathy. Finally, chapter 10 presents the amelioration of myocardial infarction through the attenuation of pro-inflammatory cytokines and matrix metalloproteinase production by Betaine, a well-known nutraceutical widely occurring in plants, animals and rich dietary sources.

Dr. V. V. Sathibabu Uddandrao
Assistant Professor
Department of Biochemistry
K.S. Rangasamy College of Arts and Science
Tamilnadu, India

Dr. Parim Brahma Naidu
DST-Inspire Faculty
ICMR-National Animal Resource Facility
for Biomedical Research (NARFBR)
Telangana, India