Phytonutrients in the Treatment of Gastrointestinal Cancer

Gastrointestinal cancer is one of the most prevalent causes of cancer-related deaths in the world. Recent research demonstrates that phytochemicals are critical in preventing and managing gastrointestinal cancer. The increased intake of phytochemicals could reduce the risk of cancer by inhibiting cancer cell proliferation, inducing apoptosis and autophagy, and suppressing angiogenesis as well as cancer cell metastasis. These mechanisms are also known to counter Helicobacter pylori infection and modulate gut microbiota. There is preliminary data suggesting that daily supplementation with high doses of certain vitamins combined with conventional therapeutic agents may enhance their growth inhibitory effects on tumor cells and protect normal tissues against some of their toxic effects.

This book attempts to fill gaps on the role of phytonutrients in the treatment of cancer in the gastrointestinal tract (GIT). It discusses the action of individual vitamins on cellular and molecular parameters and describes how vitamins inhibit protein kinase C activity, increase the production of certain growth factors, and modulate the expression of a number of oncogenes.

The book is divided into 2 parts. The first part summarizes the pathophysiology of GIT cancers and introduces readers to anticancer phytonutrients. A chapter on the status of FDA approved nutraceuticals rounds up this section. The second part of the book provides a systematic review on the different plant derived chemicals that can be used to treat GIT cancer. Each chapter in this section focuses on a specific type of phytochemical agent and its molecular mechanisms relevant to the disease.

This book will give the reader a holistic view of gastrointestinal cancer treatment and the value of natural compounds in developing functional food and drugs for preventive medicine.

Audience

General readers, physicians and caregivers

Editor(s):

Haroon Khan

Contributor(s):

Abha Meena
Bioprospection and Product Development Division
CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015
Uttar Pradesh
India
/
Academy of Scientific and Innovative Research (AcSIR)
Ghaziabad-201002, Uttar Pradesh
India

Adnan Amin
Department of Pharmacognosy
Faculty of Pharmacy, Gomal University
D.I. Khan
Pakistan

Aschner Ahmad
Department of Molecular Pharmacology
Albert Einstein College of Medicine, Bronx, NY 10463
USA

Ahmed Al-Harrasi
Natural and Medical Sciences Research Centre
University of Nizwa, PO Box 33, 616 Birkat Al Mauz
Nizwa
Oman

Ajmal khan
Natural and Medical Sciences Research Centre
University of Nizwa, PO Box 33, 616 Birkat Al Mauz
Nizwa
Oman

Ammara Riaz
Department of Zoology
Faculty of Life Sciences, Government College University, Faisalabad 38000
Pakistan

Azhar Rasul
Department of Zoology
Faculty of Life Sciences, Government College University
Faisalabad
Pakistan

Esra Küpeli Akkol
Department of Pharmacognosy
Faculty of Pharmacy, Gazi University, Etiler 06330
Ankara
Turkey

Fatemeh Abbaszadeh
Department of Neuroscience
Faculty of Advanced Technologies in Medical Sciences, Iran University of Medical Sciences
Tehran
Iran
/
Neurobiology Research Center
Shahid Beheshti University of Medical Sciences
Tehran
Iran

Faiza Rao
Fujian Provincial Key Laboratory of Reproductive Health Research
School of Medicine, Xiamen University, Xiamen
Fujian
China

Ghulam Hussain
Neurochemical Biology and Genetics Laboratory (NGL)
Department of Physiology, Faculty of Life Sciences, Government College University Faisalabad
Faisalabad
Pakistan

Imad Ahmad
Department of Molecular Pharmacology
Albert Einstein College of Medicine, Bronx, NY 10463
USA
/
Department of Pharmacy
Abasyn University Peshawar
Peshawar
Pakistan
/
Department of Pharmacy
Abdul Wali Khan University Mardan, Mardan- 23200
Pakistan
/
Department of Pharmacy
Abasyn University, Peshawar
Pakistan

Irem Tatlı Çankaya
Department of Pharmaceutical Botany
Faculty of Pharmacy, Hacettepe University, Sıhhiye 06100
Ankara
Turkey

Iqra Sarfraz
Department of Zoology
Faculty of Life Sciences, Government College University, Faisalabad 38000
Pakistan

Ilknur Ucak
Nigde Omer Halisdemir University
Nigde
Turkey

Jyoti Singh
Bioprospection and Product Development Division
CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015
Uttar Pradesh
India
/
Jawaharlal Nehru University
New Delhi-110067
India

Lubna Kanwal
Institute of Pure and Applied Zoology
University of Okara
Okara
Pakistan

Marwa A.A. Fayed
Department of Pharmacognosy
Faculty of Pharmacy, University of Sadat City, Sadat City 32897
Egypt

Muhammad Ajmal Shah
Department of Pharmacy
Hazara University
Mansehra
Pakistan

Mujtaba Shah
Department of Botany
Hazara University, Mansehra
Pakistan

Marwa A.A. Fayed
Department of Pharmacognosy, Faculty of Pharmacy
University of Sadat City
Sadat City 32897
Egypt

Muhammad Ibrahim
College of Pharmacy
University of Sargodha
Sargodha
Pakistan

Michael Ascher
Department of Molecular Pharmacology
Albert Einstein College of Medicine, Bronx, NY 10463
USA

Ozlem Bahadır Acıkara
Department of Pharmacognosy
Faculty of Pharmacy, Ankara University, Tandoğan, 06100
Ankara
Turkey

Rabia Batool
Department of Zoology
Faculty of Life Sciences, Government College University, Faisalabad 38000
Pakistan

Sajad Fakhri
Pharmaceutical Sciences Research Center, Health Institute
Kermanshah University of Medical Sciences, Kermanshah 6734667149
Iran

Shabnoor Iqbal
Department of Zoology
Faculty of Life Sciences, Government College University
Faisalabad
Pakistan

Shabana Bibi
Yunnan Herbal Laboratory
School of Ecology and Environmental Sciences, Yunnan University, Kunming 650091
Yunnan
China
/
Research Center for Sustainable Utilization of Cordyceps Bioresources in China and Southeast Asia, Yunnan University, Kunming 650091
Yunnan
China

Suaib Luqman
Bioprospection and Product Development Division
CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015
Uttar Pradesh
India
/
Academy of Scientific and Innovative Research (AcSIR)
Ghaziabad-201002, Uttar Pradesh
India

Shabnoor Iqbal
Department of Zoology
Faculty of Life Sciences, Government College University
Faisalabad
Pakistan

Sevki Adem
Chemistry Department Faculty of Science, Cankiri Karatekin University
Cankiri
Turkey

Shahid Rasool
College of Pharmacy
University of Sargodha
Sargodha
Pakistan

Shabnoor Iqbal
Department of Zoology
Faculty of Life Sciences, Government College University
Faisalabad
Pakistan

Uzma Saleem
Department of Pharmacology
Faculty of Pharmaceutical Sciences, Government College University
Faisalabad
Pakistan

Waseem Raza
Bioprospection and Product Development Division
CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015
Uttar Pradesh
India
/
Jawaharlal Nehru University
New Delhi-110067
India

Waqas Alam
Department of Pharmacy
Abdul Wali Khan University Mardan, Mardan-23200
Pakistan

Yusuf Hussain
Bioprospection and Product Development Division
CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015
Uttar Pradesh
India
/
Academy of Scientific and Innovative Research (AcSIR)
Ghaziabad-201002, Uttar Pradesh
India

Zunera Chauhdary
Department of Pharmacology
Faculty of Pharmaceutical Sciences, Government College University
Faisalabad
Pakistan

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