Editor: Haroon Khan

Phytonutrients in the Treatment of Gastrointestinal Cancer

eBook: US $59 Special Offer (PDF + Printed Copy): US $94
Printed Copy: US $65
Library License: US $236
ISBN: 978-981-5049-64-0 (Print)
ISBN: 978-981-5049-63-3 (Online)
Year of Publication: 2023
DOI: 10.2174/97898150496331230101


Gastrointestinal cancer is one of the most prevalent causes of cancer-related deaths in the world. Recent research demonstrates that phytochemicals are critical in preventing and managing gastrointestinal cancer. The increased intake of phytochemicals could reduce the risk of cancer by inhibiting cancer cell proliferation, inducing apoptosis and autophagy, and suppressing angiogenesis as well as cancer cell metastasis. These mechanisms are also known to counter Helicobacter pylori infection and modulate gut microbiota. There is preliminary data suggesting that daily supplementation with high doses of certain vitamins combined with conventional therapeutic agents may enhance their growth inhibitory effects on tumor cells and protect normal tissues against some of their toxic effects.

This book attempts to fill gaps on the role of phytonutrients in the treatment of cancer in the gastrointestinal tract (GIT). It discusses the action of individual vitamins on cellular and molecular parameters and describes how vitamins inhibit protein kinase C activity, increase the production of certain growth factors, and modulate the expression of a number of oncogenes.

The book is divided into 2 parts. The first part summarizes the pathophysiology of GIT cancers and introduces readers to anticancer phytonutrients. A chapter on the status of FDA approved nutraceuticals rounds up this section. The second part of the book provides a systematic review on the different plant derived chemicals that can be used to treat GIT cancer. Each chapter in this section focuses on a specific type of phytochemical agent and its molecular mechanisms relevant to the disease.

This book will give the reader a holistic view of gastrointestinal cancer treatment and the value of natural compounds in developing functional food and drugs for preventive medicine.


General readers, physicians and caregivers


- Pp. i
Michael Aschner*
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- Pp. ii
Haroon Khan*
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List of Contributors

- Pp. iii-v (3)

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Pathophysiology of Gastrointestinal Tract Cancers and Therapeutic Status

- Pp. 1-32 (32)
Fatemeh Abbaszadeh, Sajad Fakhri*, Sana Piri, Haroon Khan*
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Phytonutrients as a Therapeutic Modality: An Overview

- Pp. 33-57 (25)
Marwa A.A. Fayed, Muhammad Ajmal Shah*, Shahid Shah, Ghulam Mujtaba Shah, Azhar Rasul, Shabnoor Iqbal
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FDA Approval for Phytochemicals in the Treatment of Cancer

- Pp. 58-82 (25)
Waseem Raza, Jyoti Singh, Yusuf Hussain, Suaib Luqman, Abha Meena*
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Flavonoids in the Treatment of Gastrointestinal Tract Cancer

- Pp. 83-108 (26)
Waqas Alam, Haroon Khan*, Michael Ascher, Imad Ahmad
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Glycosides in the Treatment of Gastrointestinal Tract Cancer

- Pp. 109-130 (22)
Waqas Alam, Imad Ahmad, Michael Aschner, Haroon Khan*
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Terpenoıds in the Treatment of Gastrointestinal Tract Cancer

- Pp. 131-158 (28)
Esra Küpeli Akkol*, Irem Tatlı Çankaya*
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Saponins in the Treatment of Gastrointestinal Tract Cancer

- Pp. 159-181 (23)
Zunera Chauhdary, Muhammad Ajmal Shah*, Malik Hassan Mehmood, Uzma Saleem, Azhar Rasul, Ghulam Mujtaba Shah, Ajmal Khan, Ahmed Al-Harrasi, Shabnoor Iqbal, Shabana Bibi
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Alkaloids in the Treatment of Gastrointestinal Tract Cancer

- Pp. 182-208 (27)
Ammara Riaz, Azhar Rasul*, Rabia Batool, Lubna Kanwal, Ghulam Hussain, Iqra Sarfraz, Muhammad Ajmal Shah, Faiza Rao, Ilknur Ucak, Sevki Adem, Marwa A.A. Fayed
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Plant Essential Oils in the Treatment of Gastrointestinal Cancer

- Pp. 209-230 (22)
Shahid Rasool*, Muhammad Ibrahim, Mulazim Hussain, Muhammad Ajmal Shah, Adnan Amin
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Phytosterols in the Treatment of Gastrointestinal Tract Cancers

- Pp. 231-262 (32)
EsraKüpeli Akkol*, OzlemBahadır Acıkara*
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Plant Peptides in the Treatment of Gastrointestinal Cancer

- Pp. 263-284 (22)
Shabnoor Iqbal, Muhammad Ajmal Shah*, Azhar Rasul, Ajmal Khan, Ahmed Al-Harrasi, Shahid Rasool, Muhammad Naeem Amir
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Subject Index

- Pp. 285-291 (7)
Haroon Khan*
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