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Stem Cell Delivery Routes: From Preclinical Models to Clinical Applications
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Author: Sharmila Fagoonee

Stem Cell Delivery Routes: From Preclinical Models to Clinical Applications

Special Offer (PDF + Printed Copy): US $28
Printed Copy: US $28
ISBN: 978-981-5040-11-1 (Print)
ISBN: 978-981-5040-10-4 (Online)
Year of Publication: 2021
DOI: 10.2174/97898150401041210101
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Introduction

Stem Cell Delivery Routes: From Preclinical Models to Clinical Applications covers current knowledge about stem cell delivery for cell-based therapeutics. Starting with an introduction to stem cell technology, the book provides information about the main mesenchymal stem cell (MSC) delivery routes and the cell carrier materials used for delivering the cells. The main delivery routes include the liver, the kidney and the ocular surface. This introductory information is followed up with general information about stem cell based therapeutics, covering relevant topics such as the secretome and optimal delivery strategies in cell-based therapeutics. The book then progresses into the topic of in vivo cell tracking methods in preclinical and clinical studies with specific emphasis on the liver, ocular surface and kidney while also covering factors that affect the residence time, viability, and homing of MSCs with respect to the targeted location. The discussions in these chapters are accompanied by key descriptions of MSC-based therapeutic applications in rodent models and human clinical studies. The advantages and bottlenecks in clinical MSC application, and ways to improve the therapeutic efficacy of transplanted cells are also presented, rounding up the contents of the book.

Key Features

  • - A comprehensive summary of stem cell delivery for cell-based therapeutics, suitable for a broad range of readers
  • - 10 sequential chapters that enhance the reader’s understanding on the subject
  • - An Introduction to stem cell technology
  • - Coverage of 3 key stem cell transplantation routes (liver, kidney and eye)
  • - Coverage of in vivo stem cell tracking
  • - Inclusion of basic information about MSC delivery and methods of clinical applications
  • - Discussions about preclinical mouse models
  • - A perspective on stem cell bottlenecks and recent advances in biomedical engineering that enhance the clinical application of MSCs

The contents are adapted to suit readers learning about advanced stem cells therapies at all academic levels, including undergraduates, lecturers, as well as those who are curious to understand more about the importance of stem cells, and their application in cell-based therapeutics. Professionals involved in allied fields in clinical research, and biomedical engineering will also gain a substantial understanding about regenerative medicine and cell transplantation.

Audience: undergraduates, lecturers, clinical researchers, biomedical engineers (medicine, tissue engineering) and general readers interested in stem cells, and their application in cell-based therapeutics.


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Preface

In an era of organ-shortage crisis, cell-based products are receiving more and more attention as lifesaving therapeutics. For several decades now, stem cells have been the object of keen interest in the field of regenerative medicine due to their dynamicity, flexibility and interactiveness. Stem cells are present in all adult tissues and participate in regenerative processes. In particular, mesenchymal stromal/stem cells (MSCs) and their bio-products benefit from extensive research and literature due to their isolation from easily sampled tissues. Huge progress has been made in the stem cell transplantation area largely due to the use of animal models of human diseases. Nevertheless, MSCs for clinical applications are “equal, but some are more equal than others” (from G. Orwell’s Animal Farm). In fact, source tissue-associated differences exist, and can affect MSC functionality in a disease context-wise manner. Some issues regarding the delivery route, homing and engraftment still need to be dealt with in order to safely reach the desired clinical application. This book deals mainly with the various MSC delivery routes and cell carrier materials employed. The cell tracking methods in preclinical and clinical studies will be discussed, with specific emphasis on the liver, ocular surface and kidney whilst discussing factors that affect the residence time, viability, and homing of MSCs. The discussions are accompanied by key descriptions of MSC-based therapeutic applications in rodent models and human clinical studies.

The advantages and bottlenecks in MSC application in the clinics and ways to improve the therapeutic efficacy of transplanted cells are also tackled. This field requires serious standardisation in order to obtain reproducible, comparable and interpretable inter-studies results. This is an area where not all negative results are negative, and publication of results should be encouraged. Data and experience sharing will accelerate the pace towards the common goal of cell-based organ repair and regeneration.

Where are we, and where are we heading with MSC-based therapy? From single stem cells to xenorobots, this amazing field never stops surprising us. What’s in a cell and what’s around a cell all matter in the regenerative medicine field. And as we worry about the ingredients in our food, what stem cell-based bio-products we allow to inject into our body are also important. Thus, unregulated stem cell tourism should be strongly discouraged.

To the best of my knowledge, this is the first book on stem cells and derivatives delivery routes in preclinical models and clinical applications. The contents are adapted to suit undergraduates to lecturers, clinical researchers to biomedical engineers, as well as those just curious to understand more about this important and revolutionary clinical opportunity that we constantly hear about and that seems to fit well in the medical puzzle.



Sharmila Fagoonee, Ph.D
Institute of Biostructure and Bioimaging
National Research Council (CNR)
Molecular Biotechnology Center
Turin, Italy