Nanotherapeutics for the Treatment of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a leading cause of death globally. Conventional chemotherapeutic agents are unable to penetrate cancerous hepatocytes completely and are toxic to non cancerous cells and tissues. This toxicity significantly compromises the therapeutic outcome of conventional chemotherapeutic agents which is also reflected in the high mortality of the disease. Nanotherapeutics have shed new light onto HCC treatment by enabling site-specific in vivo delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes. Thus, nanotherapeutics have shown considerable potential and there is tremendous impetus for rapid translation from the pre-clinical to the clinical domain to significantly prolong the survival in HCC. In Nanotherapeutics for the Treatment of Hepatocellular Carcinoma, authoritative experts of the field have explored the important aspects of nanotherapeutics against HCC. The book exhaustively, vividly and explicitly describes the molecular pathogenesis, diagnostic aspects and nanotherapy of HCC, while also highlighting the challenges of conventional therapy and the benefits of nanotherapeutics. Chapters of the book also cover recent investigations of nanotherapeutics against HCC, types of nanomedicines, recent patents, commercially available nanotherapeutics and a future perspective to give a comprehensive review of the topic to readers. In addition to these defining features, the book provides several references for further reading. The book is an ideal resource on HCC nanotherapeutics for medical and pharmacology postgraduate students, faculties, researchers, and biomedical scientists working on HCC and nanotherapy.

Audience: Medical oncologists, pharmacologists, liver oncology specialists, researchers in pharmaceutical R&D and medicinal chemistry, postgraduates and scientific faculty members.

Editor(s):

Biswajit Mukherjee
Jadavpur University
Kolkata
India
/
Former Guest Scientist, German Cancer Research Center (DKFZ)
Heidelberg
SGermany

Contributor(s):

Akhil Suresh
Department of Pharmaceutics
Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
Manipal, Karnataka
India

Apala Chakraborty
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 700032, WB
India

Ashique Al Hoque
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 700032, WB
India

Asma Aktar
Department of Pharmacy
Jashore University of Science and Technology
Jashore-7408
Bangladesh

Ben J. Slotman
Amsterdam UMC, Vrije Universiteit Amsterdam
Department of Radiation Oncology
Cancer Center Amsterdam

Biswadip Sinha
Institute of Pharmacy, Dept. of Pharmaceutics, Biopharmaceutics & Nutricosmetics
Freie University of Berlin
Berlin
Germany

Biswajit Mukherjee
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 700032
India

Bivek Chaulagain
Department of Pharmaceutical Sciences
North Dakota State University
Fargo, North Dakota, 58105
USA

Buddhadev Layek
Department of Pharmaceutical Sciences
North Dakota State University
Fargo, North Dakota, 58105
USA

Chamalki Madhusha
Department of Chemistry, Faculty of Applied Sciences
University of Sri Jayewardenepura
Gangodawila, Nugegoda
Sri Lanka

Chetan H Metha
Department of Pharmaceutics
Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
Manipal, Karnataka
India

D. Nedra Karunaratne
Department of Chemistry
University of Peradeniya
Peradeniya
Sri Lanka

Debasmita Dutta
Department of Molecular and Human Genetics
Baylor College of Medicine
Houston, Texas 77030
United States
/
Department of Pharmaceutical Technology
Jadavpur University
Kolkata-700032, West Bengal
India

Disni Dedunupitiya
Department of Chemistry, Faculty of Science
University of Peradeniya
Peradeniya
Sri Lanka

Elisa Giovannetti
Amsterdam UMC, Vrije Universiteit Amsterdam
Department of Medical Oncology, Cancer Center Amsterdam
The Netherlands

/
Fondazione Pisana per la Scienza
Pisa
Italy

Geethi Pamunuwa
Department of Horticulture and Landscape Gardening
Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka
Makandura, Gonawila
Sri Lanka

Imalka Munaweera
Department of Chemistry, Faculty of Applied Sciences
University of Sri Jayewardenepura
Gangodawila, Nugegoda
Sri Lanka
/
Instrument Center, Faculty of Applied Sciences
University of Sri Jayewardenepura
Gangodawila, Nugegoda
Sri Lanka

Iman Ehsan
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 700032
India

Jagdish Singh
Department of Pharmaceutical Sciences
North Dakota State University
Fargo, North Dakota, 58105
USA

Kishor Mazumder
School of Optometry and Vision Science, UNSW Medicine
University of New South Wales (UNSW)
Sydney, NSW
Australia
/
School of Biomedical Sciences
Charles Sturt University
Wagga Wagga, NSW 2650
Australia
/
Department of Pharmacy
Jashore University of Science and Technology
Jashore-7408
Bangladesh

Laboni Das
School of Pharmacy
Techno India University
EM-4, Sector-V, Salt Lake, Kolkata, WB
India

Md. Emran Hossain
Department of Pharmacy
Jashore University of Science and Technology
Jashore-7408
Bangladesh

Manasadeepa Rajagopalan
East West College of Pharmacy
Bangalore, Karnataka, 560091
India

Manisheeta Ray
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 700032
India

Maria Lucia A.D Lestari
Faculty of Pharmacy Universitas Airlangga Surabaya
Department of Pharmaceutical Science
Surabaya
Indonesia

Moumita Dhara
Department of Pharmaceutical Technology
Jadavpur University
Kolkata-700032, West Bengal
India

N Udupa
Department of Pharmaceutics
Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
Manipal, Karnataka
India

Nilwala Kottegoda
Department of Chemistry, Faculty of Applied Sciences
University of Sri Jayewardenepura
Gangodawila, Nugegoda
Sri Lanka
/
Center for Advanced Materials Research (CAMR), Faculty of Applied Sciences
University of Sri Jayewardenepura
Gangodawila, Nugegoda
Sri Lanka

Nuwanthi P. Katuwavila
Faculty of Engineering and Science
National School of Business Management
Mahenwatte, Pitipana, Homagama
Sri Lanka

Pei Pei Che
Amsterdam UMC, Vrije Universiteit Amsterdam
Department of Radiation Oncology
Cancer Center Amsterdam

/
Amsterdam UMC, Vrije Universiteit Amsterdam
Department of Medical Oncology, Cancer Center Amsterdam
The Netherlands

Peter Sminia
Amsterdam UMC, Vrije Universiteit Amsterdam
Department of Radiation Oncology
Cancer Center Amsterdam

Prasanta Ghosh
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 700032
India

Ramkrishna Sen
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 700032
India

Richard N. L. Lamptey
Department of Pharmaceutical Sciences
North Dakota State University
Fargo, North Dakota, 58105
USA

Riddhi Trivedi
Department of Pharmaceutical Sciences
North Dakota State University
Fargo, North Dakota, 58105
USA

Samrat Chakraborty
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 700032
India

Sanchari Bhattacharya
Guru Nanak Institute of Pharmaceutical Science and Technology
157 f, Nilgunj Rd, Sahid Colony, Panihati
Kolkata, West Bengal
India

Sanjay Arora
Department of Pharmaceutical Sciences
North Dakota State University
Fargo, North Dakota, 58105
USA

Shreyasi Chakraborty
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 700032, WB
India

Somenath Datta
Duke Molecular Physiology Institute (DMPI)
Duke University School of Medicine
Durham, North Carolina
USA

Suresh Ajmeera
School of Biological Sciences
National Institute of Science Education and Research
HBNI, Khordha, Jatni, Odisha, 752050
India

Srinivas Mutalik
Department of Pharmaceutics
Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
Manipal, Karnataka
India

Susanthi Jayasinghe
Department of Chemistry, Faculty of Science
University of Peradeniya
Peradeniya
Sri Lanka

Thusini D. Wijerathne
Department of Chemistry
University of Peradeniya
Peradeniya
Sri Lanka

Usha Y Nayak
Department of Pharmaceutics
Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
Manipal, Karnataka
India

V Badireenath Konkimalla
School of Biological Sciences
National Institute of Science Education and Research
HBNI, Khordha, Jatni, Odisha, 752050
India

Varalakshmi Velagacherla
Department of Pharmaceutics
Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
Manipal, Karnataka
India

Veranja Karunaratne
Department of Chemistry, Faculty of Science
University of Peradeniya
Peradeniya
Sri Lanka

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