Editor: Biswajit Mukherjee

Nanotherapeutics for the Treatment of Hepatocellular Carcinoma

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISBN: 978-981-5039-75-7 (Print)
ISBN: 978-981-5039-74-0 (Online)
Year of Publication: 2021
DOI: 10.2174/97898150397401220101


Hepatocellular carcinoma (HCC) is a leading cause of death globally. Conventional chemotherapeutic agents are unable to penetrate cancerous hepatocytes completely and are toxic to non cancerous cells and tissues. This toxicity significantly compromises the therapeutic outcome of conventional chemotherapeutic agents which is also reflected in the high mortality of the disease. Nanotherapeutics have shed new light onto HCC treatment by enabling site-specific in vivo delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes. Thus, nanotherapeutics have shown considerable potential and there is tremendous impetus for rapid translation from the pre-clinical to the clinical domain to significantly prolong the survival in HCC. In Nanotherapeutics for the Treatment of Hepatocellular Carcinoma, authoritative experts of the field have explored the important aspects of nanotherapeutics against HCC. The book exhaustively, vividly and explicitly describes the molecular pathogenesis, diagnostic aspects and nanotherapy of HCC, while also highlighting the challenges of conventional therapy and the benefits of nanotherapeutics. Chapters of the book also cover recent investigations of nanotherapeutics against HCC, types of nanomedicines, recent patents, commercially available nanotherapeutics and a future perspective to give a comprehensive review of the topic to readers. In addition to these defining features, the book provides several references for further reading. The book is an ideal resource on HCC nanotherapeutics for medical and pharmacology postgraduate students, faculties, researchers, and biomedical scientists working on HCC and nanotherapy.

Audience: Medical oncologists, pharmacologists, liver oncology specialists, researchers in pharmaceutical R&D and medicinal chemistry, postgraduates and scientific faculty members.


- Pp. i
Biswajit Mukherjee
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List of Contributors

- Pp. ii-iv (3)

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Hepatocellular Carcinoma: Diagnosis, Molecular Pathogenesis, Biomarkers, and Conventional Therapy

- Pp. 1-97 (97)
Biswajit Mukherjee*, Manasadeepa Rajagopalan, Samrat Chakraborty, Prasanta Ghosh, Manisheeta Ray, Ramkrishna Sen, Iman Ehsan
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Hepatocellular Carcinoma and Therapeutic Challenges

- Pp. 98-122 (25)
Somenath Datta*
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Nanoformulations and Their Therapeutic Advantages

- Pp. 123-165 (43)
D. Nedra Karunaratne*, Thusini D. Wijerathne, Nuwanthi P. Katuwavila, Geethi K. Pamunuwa
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Nanoformulations to Limit Challenges of Conventional Therapy Against Hepatocellular Carcinoma – An Overview

- Pp. 166-218 (53)
Suresh Ajmeera, V. Badireenath Konkimalla*
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Nanotherapeutics for the Treatment of Hepatocellular Carcinoma

- Pp. 219-247 (29)
Kishor Mazumder*, Md. Emran Hossain, Asma Aktar
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A Summarized View of Lipid, Polyplex, Inorganic, and Carbon-Based Nanotherapeutics for Hepatocellular Carcinoma Treatment

- Pp. 248-279 (32)
Riddhi Trivedi, Sanjay Arora, Richard N. L. Lamptey, Bivek Chaulagain, Jagdish Singh*, Buddhadev Layek*
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Aptamers and Their Potential in Site-Specific Nanotherapy Against Hepatocellular Carcinoma

- Pp. 280-315 (36)
Debasmita Dutta*, Samrat Chakraborty, Biswajit Mukherjee, Moumita Dhara, Laboni Das
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Preclinical Studies on Nanocarrier-Mediated Delivery of Radiosensitizing Agents to Brain and Pancreatic Cancer with a Future Projection to Liver Cancer

- Pp. 316-332 (17)
Peter Sminia*, Pei Pei Che, Ben J. Slotman, Elisa Giovannetti
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Preclinical Findings for Targeted Nanotherapies to Hepatocellular Carcinoma

- Pp. 333-383 (51)
Akhil Suresh, Chetan H Metha, Varalakshmi Velagacherla, Srinivas Mutalik, Usha Y Nayak, N. Udupa*
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Potential Nanoformulation Approaches for Delivery of HCC Therapeutic Agents

- Pp. 384-448 (65)
Maria Lucia A.D Lestari, Biswadip Sinha*
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Recent Patents and Commercially Available Nanotherapeutics on Hepatocellular Carcinoma

- Pp. 449-489 (41)
Susanthi Jayasinghe, Imalka Munaweera, Disni Dedunupitiya, Chamalki Madhusha, Nilwala Kottegoda, Veranja Karunaratne*
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Future Direction of Nanotherapy in the Management of Hepatocellular Carcinoma

- Pp. 490-525 (36)
Biswajit Mukherjee*, Laboni Das, Sanchari Bhattacharya, Apala Chakraborty, Shreyasi Chakraborty, Ashique Al Hoque, Debasmita Dutta
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Subject Index

- Pp. 526-538 (13)

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