Editors: Md. Abul Barkat, Sarwar Beg, Farhan Jalees Ahmad

Nanotechnology Driven Herbal Medicine for Burns: From Concept to Application

eBook: US $69 Special Offer (PDF + Printed Copy): US $117
Printed Copy: US $83
Library License: US $276
ISBN: 978-981-5039-60-3 (Print)
ISBN: 978-981-5039-59-7 (Online)
Year of Publication: 2021
DOI: 10.2174/97898150395971210101

Introduction

Burns can cause life-threatening injury and the lengthy hospitalization and rehabilitations required in burn therapy lead to higher healthcare costs. The risk of infection has also been one of the important concerns of burn wound management. The purpose of the burn wound care management is speedy wound healing and epithelization to limit the infection. The topical application of therapeutic agents is quintessential for the longevity of patients having significant burns.

In recent times, research on herbal medicine for burn wound management has been vastly increased because of their safer toxicological profiles in contrast to synthetic medicines. Despite the promising therapeutic potential of herbal medicines in this area, herbal medications have some limitations which include low pharmacological activity, solubility and stability. Nanotechnology-based smart drug delivery approaches which involve the use of small molecules as nanocarriers, however, can help to overcome these biopharmaceutical challenges.

This book provides an overview of plant-mediated metallic nanoparticulate systems and nanophytomedicine based therapeutic treatment modalities for burn wound lesions. Nine chapters deliver updated information about nanomedicines for burn wound therapy. Contributions are written by experts in nanomedicine and phytomedicine and collectively cover the pathophysiology of wound lesions, current and future outlook of nanomedicine based treatments for burn wound lesions, the role of biocompatible nanomaterials in burn wound management, plant-mediated synthesis of metal nanoparticles for treating burn wound sepsis, phytomedicine based nanoformulations and the phyto-informatics models involved in the wound healing process which are used to select appropriate nanotherapeutic agents.

This reference serves as an accessible source of information on the topic of nanomedicine for burn treatments for all healthcare professionals (medical doctors, nurses, students trainees) and researchers in allied fields (pharmacology, phytomedicine) who are interested in this area of medicine.

Audience: Medical doctors, nurses, post graduate medical and pharmacy students, academicians and industrial scientists working in the domain of nanomedicne based herbal formulation for burn wound management.

Preface

In recent times, research on drugs for burn wounds is considered an emerging area of interest in modern healthcare domain. Researchers who are seeking to discover novel therapeutics from natural supplies are looking towards herbal medicine. Injuries due to burning are notable causes of death and morbidity and burn therapy normally expects prolonged hospitalization and rehabilitation, which may lead to higher health care costs. Therefore, burn wounds are one of the global health problems and socio-economic factors. An infection has continually been one of the important concerns of burn wound management. Burn wound infections can create severe difficulties, such as the production of wound exudates, retardation and delayed wound healing and deposition of inappropriate collagen. The purpose of burn wound care management is speedy wound healing and epithelization to limit the infection. The topical application of burn therapy is quintessential for the longevity of patients with significant burns by reducing the risks of burn wound sepsis in these cases.

Moreover, in the current epoch, the approaches for the treatment of burns employing the available drug delivery tools have been highly thwarted. With the involvement of intricate etiology and progression of the burn wound, the reliance on the available therapy as well as delivery systems is therapeutically less effective. In recent times, the research on herbal medicine has vastly increased because of their safe toxicological profiles in contrast to synthetic medicines. Natural products and their derivatives represent more than 50% of all the drugs in modern therapeutics. Over the past few decades, scientists have focused on drug discovery from plant medicines. Despite the promising therapeutic potential of herbal medicines, poor biopharmaceutical characteristics, including solubility, permeability, stability, lack of targetability, a high degree of off-target side effects, etc., hamper their clinical application. In this regard, the nanotechnology-based smart drug delivery approach can help to overcome these biopharmaceutical challenges. The current research reports are a witness of the verity of versatile applications of minuscule size nanocarriers to become the next generation treatment tools.

The objectives of the present book are to provide readers an abridged set of information on plant-mediated metallic nanoparticulate systems and nanophytomedicine based therapeutic treatment modalities for burn wound lesions. This book will be expected to deliver an updated piece of recent information and know-how to the scientists and researchers working in the field of nanomedicines based burn wound therapy. The book has been divided into nine chapters.

The first chapter provides an update on the current and future outlook of nanomedicine based treatment modalities for burn wound lesions. The second chapter highlights the importance of nanotechnology in the development of nanocarrier based phytmoedicines for burn wound treatment, including burn wound healing. The third and fourth chapters enlighten the “phyto-assisted synthesis of silver nanoparticles and its role in the management of burn wound infection. The fifth chapter describes the phytochemical-assisted gold nanoparticles potential in burn wound management. The sixth chapter provides an overview of the phytochemical-assisted zinc oxide nanoparticles synthesis approach and its potential in burns. The seventh chapter focuses on plant mediated synthesis of Titanium dioxide Nanoparticles for burn wound management. The eighth chapter provides a brief outline on phytochemical-assisted metallic nanoparticles toxicity in burn wound therapy. The last chapter discusses a novel herbal informatics approach for the management of skin burn injury.

Dr. Md. Abul Barkat
Department of Pharmaceutics,
College of Pharmacy,
University of Hafr Al-Batin
Al Jamiah, Hafr Al Batin, 39524
Saudi Arabia

Dr. Sarwar Beg
Department of Pharmaceutics,
School of Pharmaceutical Education and Research,
Jamia Hamdard,
New Delhi, India

Prof. Farhan Jalees Ahmad
Nanomedicine Research Lab,
Department of Pharmaceutics,
School of Pharmaceutical Education and Research,
Jamia Hamdard,
New Delhi, India

RELATED BOOKS

.New Findings from Natural Substances.
.Evidence-Based Research in Ayurveda against COVID-19 in Compliance with  Standardized Protocols and Practices.
.Pharmaceuticals for Targeting Coronaviruses.
.Pharmaceutical Chemistry and Production: An Introductory Textbook.