Frontiers in Clinical Drug Research

Among neurodegenerative diseases, those that lead to a state of dementia are the aim of several investigations. Dementia is a chronic disease the prevalence of which is increasing worldwide. The number of dementia patients in the world is approximately 50 million, and it is estimated that the number of patients will reach 131.5 million by 2050. This increase will be accompanied by a significant increase in medical expenditures and other expenses, especially for elderly patients. Therefore, the maintenance cost of dementia in the future is expected to be quite high. For this reason, several investigations aim, firstly, to describe the key mechanisms involved in the origin of dementia and, secondly, to establish preventive and therapeutic strategies in order to understand and mitigate this debilitating pathology.

This volume of Frontiers in Clinical Drug Research - Dementia explores the current comorbidities that cause cognitive impairment and the current management alternatives for clinical cases of dementia. The reviews contributed in these volume will provide readers with a current perspective on the subject. The topics covered in this volume include:

- Comorbidities inducing mild cognitive impairment - an evaluation of the risk caused by some pathological conditions
- Tau-targeted therapy in Alzheimer's disease - history and current state
- Emerging nanotherapeutic strategies in Alzheimer's disease
- Implication of dehydroepiandrosterone on dementia related to oxidative stress
- Polyphenol compounds as potential therapeutic agents in Alzheimer’s disease

The volume is a timely update on dementia treatment for clinical physicians, neurologists, gerontologists, pharmaceutical and medicinal chemistry researchers, and physiologists.

Audience: clinical physicians, neurologists, gerontologists, pharmaceutical and medicinal chemistry researchers, and physiologists.

Editor(s):

José Juan Antonio Ibarra Arias

Contributor(s):

Alejandra Romo
Centro de Investigación en Ciencias de la Salud (CICSA)
Facultad de Ciencias de la Salud Universidad Anáhuac México
Norte
Mexico

Almudena Chávez-Guerra
Centro de Investigación en Ciencias de la Salud (CICSA)
Facultad de Ciencias de la Salud Universidad Anáhuac México
Norte
Mexico

Antonio Ibarra
Centro de Investigación en Ciencias de la Salud (CICSA)
Facultad de Ciencias de la Salud Universidad Anáhuac México
Norte
Mexico

Anamaria Jurcau
Faculty of Medicine and Pharmacy, Clinical Municipal Hospital
University of Oradea
Romania
Oradea

Adriane Bello Klein
Institute of Basic Health Sciences, Department: Physiology R. Sarmento Leite
Federal University of Rio Grande do Sul (UFRGS)
CEP 90035-190- Porto Alegre, RS
Brazil

Alexandre Castro
Institute of Basic Health Sciences, Department: Physiology R. Sarmento Leite
Federal University of Rio Grande do Sul (UFRGS)
CEP 90035-190- Porto Alegre, RS
Brazil

Alex Sander da Rosa Araujo
Institute of Basic Health Sciences, Department: Physiology R. Sarmento Leite
Federal University of Rio Grande do Sul (UFRGS)
CEP 90035-190- Porto Alegre, RS
Brazil

Aziz Eftekhari
Russian Institute for Advanced Study
Moscow State Pedagogical University
1/1, Malaya Pirogovskaya St, Moscow, 119991
Russian Federation
/
Pharmacology and Toxicology Department
Maragheh University of Medical Sciences
Maragheh
Iran

Alex France Messias Monteiro
Postgraduate Program in Natural and Bioactive Synthetic Products
Health Sciences Center, Federal University of Paraíba
Castelo Branco Street, João Pessoa
PB – Brazil

Cumali Keskin
Medical Laboratory Techniques, Vocational Higher School of Healthcare Studies
Mardin Artuklu University
Mardin
Turkey

Daiane da Rocha Janner
Carlos Chagas Filho Institute of Biophysics – Neurogenesis Lab Av. Carlos Chagas Filho
Federal University of Rio de Janeiro (UFRJ)
373–CEP 21941-902, Rio de Janeiro
RJ- Brazil

Elham Ahmadian
Kidney Research Center
Tabriz University of Medical Sciences
Tabriz
Iran

Edeildo Ferreira da Silva-Júnior
Chemistry and Biotechnology Institute
Federal University of Alagoas
57072-970, Maceió
AL – Brazil

Érika Paiva de Moura
Postgraduate Program in Natural and Bioactive Synthetic Products
Health Sciences Center, Federal University of Paraíba
Castelo Branco Street, João Pessoa
PB – Brazil

Francisco Jaime Bezerra Mendonça Júnior
Laboratory of Synthesis and Drug Delivery
State University of Paraíba, Horácio Trajano de Oliveira Street
João Pessoa
PB – Brazil

Herbert Igor Rodrigues de Medeiros
Postgraduate Program in Natural and Bioactive Synthetic Products
Health Sciences Center, Federal University of Paraíba
Castelo Branco Street, João Pessoa
PB – Brazil

Igor José dos Santos Nascimentos
Chemistry and Biotechnology Institute
Federal University of Alagoas
57072-970, Maceió
AL – Brazil

Irada Huseynova
Institute of Molecular Biology & Biotechnologies
Azerbaijan National Academy of Sciences, 11 Izzat Nabiyev
Baku AZ 1073
Azerbaijan

Luciana Scotti
Postgraduate Program in Natural and Bioactive Synthetic Products
Health Sciences Center, Federal University of Paraíba
Castelo Branco Street, João Pessoa
PB – Brazil
/
Teaching and Research Management
University Hospital of the Federal University of Paraíba
João Pessoa
PB – Brazil

Macarena Fuentes
Centro de Investigación en Ciencias de la Salud (CICSA)
Facultad de Ciencias de la Salud Universidad Anáhuac México
Norte
Mexico

Maria Helena Vianna Metello Jacob
Montfort Hospital – Institut du Savoir 745
Montreal Road, Ottawa
ON K1K 0T1, Canada

Marcus Tullius Scotti
Postgraduate Program in Natural and Bioactive Synthetic Products
Health Sciences Center, Federal University of Paraíba
Castelo Branco Street, João Pessoa
PB – Brazil

Natan Dias Fernandes
Postgraduate Program in Natural and Bioactive Synthetic Products
Health Sciences Center, Federal University of Paraíba
Castelo Branco Street, João Pessoa
PB – Brazil

Roxana Rodríguez-Barrera
Centro de Investigación en Ciencias de la Salud (CICSA)
Facultad de Ciencias de la Salud Universidad Anáhuac México
Norte
Mexico

Renad I. Zhdanov
Russian Institute for Advanced Study
Moscow State Pedagogical University
1/1, Malaya Pirogovskaya St, Moscow, 119991
Russian Federation

Rovshan Khalilov
Russian Institute for Advanced Study
Moscow State Pedagogical University
1/1, Malaya Pirogovskaya St, Moscow, 119991
Russian Federation
/
Department of Biophysics and Biochemistry
Baku State University
Baku
Azerbaijan
/
Institute of Radiation Problems
Azerbaijan National Academy of Science
Baku
Azerbaijan

Soheila Montazersaheb
Molecular Medicine Research Center
Tabriz University of Medical Sciences
Tabriz
Iran

Solmaz Maleki Dizaj
Dental and Periodontal Research Center
Tabriz University of Medical Sciences
Tabriz
Iran

Soodabeh Davaran
Department of Medicinal Chemistry,School of Pharmacy
Tabriz University of Medical Sciences
Tabriz
Iran

Vharoon Sharma Nunkoo
Faculty of Medicine and Pharmacy, Clinical Municipal Hospital
University of Oradea
Romania
Oradea

Yalda Jahanbani
Department of Medicinal Chemistry,School of Pharmacy
Tabriz University of Medical Sciences
Tabriz
Iran

Yolanda Cruz
Centro de Investigación en Ciencias de la Salud (CICSA)
Facultad de Ciencias de la Salud Universidad Anáhuac México
Norte
Mexico

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