Editors: Atta-ur-Rahman, M. Iqbal Choudhary

Frontiers in Drug Design and Discovery

Volume 11

eBook: US $69 Special Offer (PDF + Printed Copy): US $126
Printed Copy: US $91
Library License: US $276
ISSN: 1574-0889 (Print)
ISSN: 2212-1064 (Online)
ISBN: 978-981-5036-88-6 (Print)
ISBN: 978-981-5036-87-9 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150368791221101


Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field.

Volume 11 of this series brings together reviews covering immunotherapy of sepsis, new antimalarials, and the medicinal use of onions for respiratory diseases, among other topics.

Topics included in this volume are:

- Heme-oxygenase and autophagy connected as a cytoprotective mechanism: potential therapeutic target

- Development of recombinant therapeutic proteins in animal cells: Challenges and solutions

- Artemisinin Analogues as a Novel Class of Antimalarial Agents: Recent Developments, Current Scenario and Future Perspectives

- The effects of Allium cepa and their derivatives on respiratory diseases and the possible mechanisms of these effects

- Immunotherapy of Sepsis


In view of emerging epidemics and infectious diseases as well as the increasing prevalence of metabolic and neurological disorders, it is important to identify new drug targets in order to discover and develop safer and more effective drugs. The 11th volume of Frontiers in Drug Design and Discovery is a collection of five scholarly written reviews, each focused on a specific disease, covering various aspects of development of therapeutics.

Vasconcellos et al have contributed a comprehensive review on the relationship of heme-oxygenase (HO) with autophagy. They have proposed to use this nexus as a drug development strategy against chronic inflammatory and stress related disorders. The chapter by Mufarrege et al discusses the challenges related to the high yield production of biopharmaceuticals in animal cells and related issues, including immunogenicity. Artemisinin has attracted scientific interest as a potent antimalarial in the past few decades. Chaudhary and Tiwari have contributed a comprehensive review on the synthesis of artemisinin peroxide analogues and their antimalarial activities as compared to the parent natural product and other commonly used antimalarial drugs.

In the next chapter, Boskabady et al discuss the effect and mechanisms of action of Allium cepa (onion) extracts, and the well-known phenolic and sulphur phytoconstituents in chronic inflammatory respiratory disorders, both for treatment and prevention. Sepsis remains a major cause of morbidity and mortality. Immunotherapy has therefore been explored extensively as a treatment option for sepsis. Soleimanpour and Dolati have contributed a comprehensive review on this emerging new mode of treatment of sepsis.

We would like to thank all the authors for their excellent contributions. We greatly appreciate the efforts of Miss. Mariam Mehdi (Assistant Manager Publications) and Mr. Mahmood Alam (Director Publications) for the efficient production of this volume. We are confident that this volume will be widely appreciated by the scientific community.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge, Cambridge


M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi, Karachi