Foreword

Self-emulsifying drug delivery system (SEDDS) is a significant approach for improving the rate and extent of absorption of hydrophobic or lipophilic drugs that come under class II and IV of the Biopharmaceutical Classification System (with low solubility), and exhibits a dissolution rate-limited absorption. SEDDS formulations lead to increased drug solubility and bioavailability, avoidance of food effect, and enhanced environmental degradation stability. Enhanced oral bioavailability allows dose reductions and high efficiency of drug release. In the gastrointestinal tract (GIT), self-emulsifying formulations spread readily, and the digestive motility of the stomach and intestine provides the stimulation required for self-emulsification.

This reference book on SEDDS specifically addresses the basic aspects and current research going on in this field. In the following nine chapters, various authors give a comprehensive review of SEDDS, covering the basic components and latest advances such as solid-SMEDDS, herbal SEDDS formulations along with discussions on pharmacokinetic and in vitro digestion models for estimation of SEDDS.

The book is an excellent reference work for academicians, students, pharmaceutical industry professionals as well as research scientists involved in the investigation and development of SEDDS.