Author: Marco Brito-Arias

Enzymes Involved in Glycolysis, Fatty Acid and Amino Acid Biosynthesis: Active Site Mechanism and Inhibition

eBook: US $79 Special Offer (PDF + Printed Copy): US $134
Printed Copy: US $95
Library License: US $316
ISBN: 978-981-14-6088-3 (Print)
ISBN: 978-981-14-6090-6 (Online)
Year of Publication: 2020
DOI: 10.2174/97898114609061200101

Introduction

Multidisciplinary research involving crystallography, kinetic studies, molecular docking, genetics and other techniques in biochemistry has yielded a wealth of knowledge about the reaction mechanisms in cellular processes. This knowledge has allowed researchers to understand, in a better way, the normal functioning of the cell process, which is used as a reference point for learning about and preventing or correcting pathologies that cause diseases.

This enzymology reference is a thorough compendium about reaction mechanisms occurring between the major enzymes related to the biosynthetic pathways of 3 important types of biological compounds – 6-carbon carbohydrates, fatty acids and amino acids – and their substrates, cofactors and residues. Readers will gain an understanding of the interaction between substrates or ligands with specific amino acid residues in biosynthetic enzymes. This understanding builds a foundation for learning about the biochemistry of different inhibitors used in the treatment of several diseases such as cancer, infectious diseases, and metabolic syndrome alterations such as diabetes and obesity.

Enzymes covered in the book include aldolases, isomerases, kinases, mutases, synthases, dehydrogenases, reductases, transferases, hydrolases, lyases among others, all of which are wide spread in biochemical transformations.

This reference, with its insights on common biochemical enzymes serves as a handy guide for students, researchers and professionals involved academia or industry related to pharmaceutical development, healthcare, food chemistry and other disciplines.

Preface

The present eBook entitled “Enzymes Involved in Glycolysis, Fatty Acid and Amino Acid Biosynthesis: Active Site Mechanism and Inhibition” comprehends a thorough revision about the known reaction mechanism occurring between the enzymes related to the mentioned biosynthetic pathways with their substrates, cofactors and residues. Different disciplines provide a wealth of knowledge including crystallographic studies, kinetic studies, docking, genetic mutagenesis and biochemistry. The knowledge about the reaction mechanism is primordial to understand in a better way the normal functioning of the cell process, which is used as a starting point for preventing or to correct pathologies. Currently, the drug design relies strongly on the understanding of the interaction between the substrates or ligands with the amino acid residues and derived from these studies, a wealth of potent inhibitors have emerged for the treatment of several diseases such as cancer, tuberculosis, anti-parasitic, and also importantly metabolic syndrome alterations such as diabetes and obesity.

The enzymatic reaction mechanism includes aldolase, isomerase, kinase, mutase, synthase, dehydrogenase, reductase, transferase, hydrolase, lyase etc., all of them widespread in all biochemical transformations.

This eBook pretends to serve as a tool for professionals involved in pharmaceutical, health, food and other related disciplines, providing well known, and key insights of the reaction mechanism occurring at the molecular level between the biological catalyst and the chemical ligands and how the transformation occurs within the cell.

ACKNOWLEDGEMENTS

The author is grateful to the following for financial support:

  • Estímulo al Desempeño Docente (EDD) IPN 20774
  • Comisión de Operación y Fomento de Actividades Académicas del Instituto Politécnico Nacional (COFAA-IPN) 9500068
  • CONACyT-SNI 14636


CONFLICT OF INTEREST

The authors confirm that this chapter contents have no conflict of interest.

Marco Brito-Arias
National Polytechnic Institute of Mexico
Avenida Acueducto s/n La Laguna Ticomán 07340
México City,
México

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