• Describe the historical background about the development of antipsychotic therapeutics.
• Apply the principles of fundamental pathophysiology of schizophrenia and other psychotic disorders and receptors associated with it to their pharmacological action.
• Recognize the dopamine and its chemical analogues and identify the essential structural features to become an antipsychotic agent.
• Differentiate between the positive and negative symptoms and extrapyramidal side effects and distinguish between the typical and atypical classes of antipsychotics.
• Apply the principles of structure-activity relationships to the antipsychotic drugs.
• Delineate the clinical significance of all classes of antipsychotic drugs and their therapeutic indications.
• Identify the therapeutic use, side effects and metabolic pathways of selected first- and second-generation antipsychotic agents.
Total Pages: 109-162 (54)
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