• Relate principles of acetylcholine (ACh) discovery, biosynthesis, storage, transport, and metabolism.
• Describe the effects of agonism and antagonism of cholinergic receptors and modulation of ACh levels at the synapse.
• Describe cholinergic biochemistry and neurochemical interactions. • Compare muscarinic and nicotinic receptor subtypes.
• Illustrate the mechanism of action, structure-activity relationship (SAR), metabolites, and clinical considerations of:
▪ muscarinic receptor agonists
▪ muscarinic receptor antagonists (anticholinergics)
▪ acetylcholinesterase (AChE) inhibitors
o reversible
o quasi-irreversible
o antidotes for irreversible inhibitors
▪ neuromuscular blocking agents
Total Pages: 1-58 (58)
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