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Ovarian Cancer – Challenges & Innovations

by

Tamara L. Kalir

eISBN: 978-981-14-2186-0, 2019
ISBN: 978-981-14-2185-3



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This informative book provides a wealth of information on ovarian cancer. The book opens with a discussion of contemporary management ...[view complete introduction]

Foreword

I was delighted when I received a request by Dr. Tamara Kalir to write a foreword for this e-book because of my admiration of the leading research conducted by her and her colleagues in ovarian cancers at Mount Sinai Hospital in the past two decades. This book covers a range of topics with a novel juxtapositioning of topics as diverse as: conventional oncology approaches, psychiatric considerations, and the role of belief in healing with commentaries by alternative practitioners.

This book starts with an in-depth overview by Dr. Jamal Rahaman, a leading gynecologic oncologist, on the current management of ovarian cancer, including surgery and chemotherapy that additionally discusses the prospects of emerging therapies inclusive of such entities as immune-modulation and cancer vaccines. Both the clinicians and pathologists would find informative the second chapter by Jessica Beyda, M.D., and Sedef Everest, M.D. on the pathology of ovarian cancer: detailing the various histologic types of epithelial ovarian cancer including low- and high-grade serous carcinoma, mucinous carcinoma, clear cell carcinoma, endometrioid carcinoma; their symptoms, gross pathologic findings, tumor histology, immunohistochemical features available for arriving at the diagnosis, molecular features and prognosis. Also, a discussion on pathogenesis of ovarian cancer with details of key genes and serous tubal intraepithelial carcinoma is presented. Each entity is illustrated by digital photomicrographs, for a total of sixty-nine labeled full-color pictures. Chapter 3 written by Stave Kohtz, Ph.D., further details the molecular pathogenesis of the various ovarian epithelial cancers per the dualistic model (Type I and Type II cancers), including discussion of: TP53, BRACA 1 and 2, PTEN, KRAS,CTNNB1, ARID1A, SWI/SNF, KLF5, CCNE1 and others, microRNAs, and concludes with mention of future pathways for targeted therapy. Gonzalo Carrasco-Avino, M.D. gives a step-by-step demonstration in Chapter 4, on how to utilize Public Gene Expression Omnibus (GEO) datasets and apply a Functional Genomics approach to study gene interactions of high-grade serous carcinoma in canonical pathways, in silico analysis activation of these pathways, and how chemotherapeutic drugs potentially affect them. Chapter 5 written by Jacob Appel, M.D., J.D., M.P.H., discusses the psychological aspects of healing in ovarian cancer, including psychiatric conditions such as depression and anxiety, demoralization, delirium; complicating factors such as loss of fertility, pain, fatigue; cosmetic issues; burnout in caregivers, treatments, and end-of-life considerations. The closing chapter written by Tamara Kalir, M.D., Ph.D., gives an historic overview of practitioners and their practices to explore the role of belief in the healing process, citing experiments on the placebo and nocebo effects, and mind-body interaction, with quotes from a diverse range of healers ranging from medical doctors to medical intuitive.

The material presented herein is current and is helpful, informative and inspiring. Clinicians, researchers and laypersons will find the information in this book invaluable to their work, research, and care for their patients and loved ones.

Linus Chuang MD
Professor and Network Chair
Department of Obstetrics and Gynecology
Western Connecticut Health Network
University of Vermont Larner College of Medicine
USA

Preface

Significant research has been carried out on ovarian cancer, inclusive of clinicians’ and patients’ points of view. My goal was to add something new. Currently ovarian cancer is, for many women a chronic disease which resists cure. The allure of personalized medicine is that we may one day identify biomarkers unique to a patient’s ovarian tumor - the ‘Achilles heel’ of the tumor - that when targeted, results in complete remission of the disease. Today, we are at the beginning this journey. A new book on ovarian cancer would include a discussion on current medical practices and treatments, along with pathogenesis and pathological classifications. The authors (respectively Dr. Jamal Rahaman, and Drs. Jessica Beyda & Sedef Everest) have given excellent and thorough overviews of these subjects. The novelty of this book is threefold: i) commentary on future directions in treatment (respectively Drs. Jamal Rahaman and Stave Kohtz), ii) the use of in silico analysis/other computer programs to identify candidate genes for targeted therapy and likelihood of success (Dr. Gonzalo Carrasco-Avino), and iii) discussions on the psycho-spiritual aspects of healing. Dr. Jacob Appel has given a sensitive and comprehensive overview of psychological factors affecting patients with ovarian cancer and, finally, I have included a chapter on the role of belief in healing, with discussions on the placebo and nocebo effects, and the potent influence of our thoughts on our body’s ability to heal.

This book is intended for a wide audience including: medical students, house staff, attending physicians, physician assistants, medical researchers, assistants, patients and other interested individuals. My hope is that readers will gain greater knowledge and understanding of ovarian cancer, and will gain their own inspirations and insights into healing and well being.

Tamara L. Kalir, M.D., Ph.D.
Associate Professor of Pathology
The Icahn School of Medicine at Mount Sinai
USA

List of Contributors

Author(s):
Tamara L. Kalir




Contributor(s):
Jamal Rahaman
Division of Gynecologic Oncology
Icahn School of Medicine at Mount Sinai New York
New York
USA


Lorene M. Yoxtheimer
Tulane Medical Center
New Orleans, LA
USA


Jessica Beyda
St. Francis Hospital Roslyn.
New York
USA


Sedef Everest
Fellow in Pathology
The Mount Sinai Health
New York
USA


Stave Kohtz
Pathology Foundational Sciences
Central Michigan University College of Medicine
USA


Gonzalo Carrasco-Avino
Pathologist, Clinica las Condes, Pontificia Universidad Catolica de Chile, and Adjunct Assistant Professor of Pathology
The Icahn School of Medicine at Mount Sinai
New York
USA


Benjamin Greenbaum
Medicine and Pathology
The Icahn School of Medicine at Mount Sinai
New York
USA


Mireia Castillo-Martin
Molecular and Experimental Pathology Laboratory, Champalimaud Centre for the Unknown
Lisbon, Portugal; and Assistant Professor of Research, Department of Pathology, The Icahn School of Medicine at Mount Sinai
New York
USA


Adolof Firpo
The Icahn School of Medicine at Mount Sinai
New York
USA


Carlos Cordon-Cardo
The Icahn School of Medicine at Mount Sinai
New York
USA


Tamara Kalir
The Icahn School of Medicine at Mount Sinai
New York
USA


Jacob M. Appel
Psychiatry and Medical Education, Director of Ethics Education in Psychiatry
Icahn School of Medicine at Mount Sinai
New York
USA




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