Editors: Atta-ur-Rahman, M. Iqbal Choudhary

Frontiers in Drug Design and Discovery

Volume 10

eBook: US $79 Special Offer (PDF + Printed Copy): US $142
Printed Copy: US $103
Library License: US $316
ISSN: 1574-0889 (Print)
ISSN: 2212-1064 (Online)
ISBN: 978-981-14-2155-6 (Print)
ISBN: 978-981-14-2156-3 (Online)
Year of Publication: 2021
DOI: 10.2174/97898114215631211001

Introduction

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field.

The tenth volume of this series brings together reviews covering topics related to the treatment of neoplasms, systems biology, respiratory diseases among others.

Topics included in this volume are:

- Recombinant Protein Production: from Bench to Biopharming

- Plant Virus Nanoparticles and Virus like Particles (VLPs): Applications in Medicine

- MAO Inhibitory Activity Of 4, 5-Dihydro-1 HPyrazole Derivatives: A Platform To Design Novel Antidepressants

- Flavonoids Antagonize Effects of Alcohol in Cultured Hippocampal Neurons: A Drug Discovery Study

- Hybrid Smart Materials for Topical Drug Delivery: Application of Scaffolds

Preface

Development of new therapeutics requires a strong science base in terms of understanding the diseases at the molecular levels, and then identifying new drug leads against novel targets. The world scientific literature is now inundated with a lot of work in this field, and it is often difficult for a researcher to find focused and comprehensive accounts of the topic of his interest. The book series, “Frontiers in Drug Design and Discovery” was an attempt to fill this important gap. Volume 10 of the series is a collection of four scholarly written reviews and a research article, contributed by leading experts in the field of drug discovery and development.

Ansari et al. have contributed an excellent review on the recent progress made in the research, manufacture, and quality assurance of various classes of industrial, therapeutic and diagnostic proteins. Collectively termed biopharmaceuticals, these proteins are used for the treatment of haemophilia, insulin-dependent diabetes, and various immune and cardiovascular diseases. Recombinant expression systems used in the production of biopharmaceuticals are the focus of this article. Another review by Hefferon et al. provides an excellent insight into the emerging field of virus like particles (VLP), various nanoparticles (VNP), and the safe and effective applications in drug delivery and transportation of biomedical agents. Badavath and Jayaparakash have contributed an article on the recent development of monoamine oxidase inhibitors (MOAs) as new and effective antidepressants. Among the MOAs, 4,5-dihydro-1H-pyrazole derivatives have special merit due to their interesting molecular architecture, and nanomolar inhibitory potential against MOA enzymes from various sources. Korkotian et al. have focused on the problems associated with the treatment of alcohol intoxication. They propose to employ polyphenolic substances of plant origin, collectively called flavonoids, for this purpose. Flavonoids are known to possess a wide range of biological activities. The authors have presented the effects of flavonoids from plants of Scrophulariacae family on functional properties of rat hippocampal neural cultures in the presence of ethanol. The last review of Barradas et al. is an account of the development of novel drug delivery systems, based on smart polymeric scaffolds, for topical applications. Their physicochemical properties, safety, and stimuli-response characteristics as effective drug nanocarriers are presented.

We are extremely grateful to authors for their excellent scholarly contributions, and for the timely submission of their reviews. The 10th volume of the ebook series is the result of the efficient coordination and excellent management Ms. Mariam Mehdi (Assistant Manager Publications), and team leader Mr. Mahmood Alam (Director Publications). We are confident that this volume will receive wide appreciation from students, young researchers, and established scientists.


Atta-ur-Rahman, FRS
Kings College
University of Cambridge, Cambridge
UK

&

M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi, Karachi
Pakistan

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