Editor: Blas Gil-Extremera

Series Title: Recent Advances in Alzheimer Research

Alzheimer's Disease: Pathological and Clinical Findings

Volume 3

eBook: US $79 Special Offer (PDF + Printed Copy): US $158
Printed Copy: US $119
Library License: US $316
ISSN: 2452-2554 (Print)
ISSN: 2452-2562 (Online)
ISBN: 978-981-14-0512-9 (Print)
ISBN: 978-981-14-0513-6 (Online)
Year of Publication: 2019
DOI: 10.2174/97898114051361190301


Alzheimer's disease is the most frequent cause of dementia that slowly and progressively causes cognitive impairment and profoundly alters the daily activities of the patients. Approximately, ten percent of all persons over the age of seventy experience significant memory loss, and in more than half of the cases, the cause is Alzheimer's disease.

This reference book is an update on the most relevant pathological and clinical findings of this neurological disorder. Chapters cover the basic hypothesis of Alzheimer’s disease, pathological features of the disease in the brain, Alzheimer’s disease diagnosis and therapy. Information provided in the book is focused on research in developed countries.

The book offers students of medicine and nursing as well as medical practitioners and specialists (internists, neurologists, gerontologists, and psychiatrists), the necessary information to understand the pathological and clinical aspects of the disease in depth, with the goal of improving medical outcomes in the care of their patients.


Alzheimer's disease was named after Dr. Alois Alzheimer (1864-1915) in 1906 who described two important microscopic findings: neuritic plaques and neurofibrillary tangles in the brain of a 55-year old female, who died from dementia. These two lesions are characteristic but not pathognomonic of the disease. Alzheimer’s disease is the most common form of dementia in the Western countries. The origin of the disease is still unclear although it has been demonstrated that ageing in the major risk factor. The management of this neurologic disorder is frustrating since, until now, no specific and curative treatment has been found, and so far, the only possibility to fight against the disease is to try to improve as much as possible the symptoms and the neurologic effects of the disease.

Bentham e-Book Editorial had the courtesy to offer to our research group, the invitation to write and update of the Alzheimer’s disease. Nine specialized neurologists and general physicians whose expertise are based on dementia and old people diseases have participated in this interesting and exciting project.

This book has nine chapters covering different aspects of the disease such as amyloid hypothesis, symptoms, pain, dysphagia, neuroimaging, brain connectivity, treatment, nutrition and palliative care. I believe that this book can be of great interest for students, physicians, internists, and even for patients, and their families.

Finally, I would like to thank all the authors in this book, also Esperanza Velasco Rodríguez for the preparation of the manuscripts, and the Bentham Publishing Editorial that gave us this valuable opportunity.

Blas Gil-Extremera
Department of Medicine,
Universidad de Granada,


.Frontiers in Clinical Drug Research - CNS and Neurological Disorders.
.Frontiers in Clinical Drug Research - CNS and Neurological Disorders.
.Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches.
.Frontiers in Clinical Drug Research - CNS and Neurological Disorders.
.Traditional Medicine for Neuronal Health.
.Recent Advances in the Treatment of Neurodegenerative Disorders.
.Advances in Alzheimer Research.