Frontiers in Anti-Cancer Drug Discovery

Volume 10

by

Atta-ur-Rahman , M. Iqbal Choudhary

DOI: 10.2174/97898114007111191001
eISBN: 978-981-14-0071-1, 2019
ISBN: 978-981-14-0191-6
ISSN: 2451-8395 (Print)
ISSN: 1879-6656 (Online)



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Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and disc...[view complete introduction]
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Table of Contents

Preface

- Pp. i
Atta-ur-Rahman and M. Iqbal Choudhary
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List of Contributors

- Pp. ii
Atta-ur-Rahman and M. Iqbal Choudhary
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Challenges in the Management of Hepatoblastoma

- Pp. 1-22 (22)
Ioannis A. Ziogas and Georgios Tsoulfas

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The Emerging Role of Monocarboxylate Transporter-1 in Cancer: Overview and Therapeutic Opportunities

- Pp. 23-42 (20)
Gouthami Thumma, Kiran Gangarapu, Anvesh Jallapally and Anil Kumar Mondru

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In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery

- Pp. 43-61 (19)
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon and Sameera Ranganath Samarakoon

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Polyphenols and Cancer

- Pp. 62-110 (49)
Peramaiyan Rajendran, Abdullah M. Alzahrani, Thamaraiselvan Rengarajan, Ravi Kaushik, Palanisamy Arulselvan and Arthanari Umamaheswari

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Glioblastoma Multiforme; Drug Resistance & Combination Therapy

- Pp. 111-130 (20)
Megha Gautam, Saumya Singh, Mehak Aggarwal, Shweta Dang, Reema Gabrani and Manish K Sharma

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Recent Advances in the Development of Mesoporous Anti-Cancer Drug Nanocarriers

- Pp. 131-179 (49)
Jessica Flood-Garibay, Castro-Pastrana and Miguel A. Méndez- Rojas

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Cutting Edge Targeting Strategies Utilizing Nanotechnology in Breast Cancer Therapy

- Pp. 180-228 (49)
Samipta Singh, Priyanka Maurya and Shubhini A. Saraf

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Subject Index

- Pp. 229-238 (10)
Atta ur-Rahman and M. Iqbal Choudhary
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Preface

Cancers are among the most fearful human diseases. This has attracted the attention of scientists, policy makers, media, and general publica alike. There are dozens of different types of cancers, with complex etiologies, heterogenicities and complex risk factors. This makes the treatment of cancer a major challenge. Recent advances in the field of anti-cancer drug discovery and development is largely based on a better understanding of cancer biology and molecular genetics. This book series entitled, “Frontiers in Anti-Cancer Drug Discovery” is regularly publishing excellent articles in this field and has gained reputation of being thorough, up-to-date and inclusive.

The present 10th volume contains seven excellent chapters focusing on various aspects of cancer biology, and advances in anti-cancer drug development. Ziogas and Tsoulfas have focused their article on general characteristics of hepatoblastoma, the third most common pediatrics tumor of the abdomen. They have reviewed various treatment options in different stages of the disease. The review by Gangarapu et al., is focused on the importance of monocarboxylate transporters (MCT) as a novel anti-cancer drug target. They summarize the recent developments in the field of MCT inhibitors, a new class of drugs against various cancers.

Biological screenings play an important role in initial drug discovery process. For pre-clinical anticancer drug lead discovery, a large number of in vitro cell-based anti-proliferative assays have been developed which are critically reviewed in the next chapter by Ediriweera et al. The nexus between diet and the onset of malignancies is the central theme of the article by Rajendran et al., They have reviewed the anticancer effects of major polyphenolic compounds found in common foods, in the context of their molecular mechanisms. Glioblastoma multiforme (GBM) is an aggressive lethal form of brain tumor, with poor prognosis. The chapter Review of Gabrani et al., is focused on recent development of synergistic combinations various classes of drugs with temozolomide, which provide substantial survival advantages to GBM patients. The central theme of the last two reviews is recent developments of anti-cancer drug delivery systems by using nanocarriers. Mendez-Rojas et al have reviewed recent progress on the development of mesoporous nanocarriers as efficient systems for controlled transport and delivery of various anti-cancer drugs, whereas the last review by Saraf et al., mainly deals with the active targeting of anti-breast cancer drugs by using various kinds of nanomaterials, and the challenges faced in these processes.

We are grateful to all contributors for their excellent scholarly contributions, and for the timely submissions of their reviews. We would like to express our gratitude to the excellent coordination of Ms. Fariya Zulfiqar (Manager Publications), Mr. Shehzad Naqvi (Editorial Manager Publications) and Mr. Mahmood Alam (Director Publications) of Bentham Science Publishers for the timely completion of the volume in hand. We sincerely hope that the efforts of the authors and the production team will help readers in a better understanding of the subject and motivate them to conduct further good quality research.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
UK

&

M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi
Karachi Pakistan

List of Contributors

Editor(s):
Atta-ur-Rahman
Kings College
University of Cambridge
Cambridge
UK


M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
University of Karachi
Karachi, 75270
Pakistan




Contributor(s):
Anvesh Jallapally
Department of Pharmaceutical Sciences
University of Antwerp
Antwerp
Belgium


Anil Kumar Mondru
Department of Molecular and Clinical Cancer Medicine
Institute of Translational Medicine, University of Liverpool
Liverpool
United Kingdom


Abdullah M Alzahrani
Department of Biological Sciences
College of Science, King Faisal University, Hufouf, Al Hassa
Saudi Arabia


Arthanari Umamaheswari
Department of Plant Biology and Plant Biotechnology
Presidency College, Chennai
Tamilnadu
India


Georgios Tsoulfas
1st Department of Surgery
Aristotle University of Thessaloniki
Thessaloniki
Greece


Gouthami Thumma
Department of Pharmaceutics
Mother Theresa College of Pharmacy
Hyderabad, 500 088, Telangana
India


Ioannis A. Ziogas
School of Medicine
Aristotle University of Thessaloniki
Thessaloniki
Greece


Jessica Flood-Garibay
Department of Chemical & Biological Sciences and Laboratory of Nanotechnology and Molecular Biomedicine Research, School of Sciences
Universidad de las Américas Puebla
San Andrés Cholula, Puebla
México


Kiran Gangarapu
School of Pharmacy
Anurag Group of Institutions
Hyderabad, 500 088, Telangana
India


Kamani Hemamala Tennekoon
Institute of Biochemistry, Molecular Biology and Biotechnology
University of Colombo, 90, Cumaratunga Munidasa Mawatha
Colombo 03
Sri Lanka


Lucila I. Castro-Pastrana
Department of Chemical & Biological Sciences and Laboratory of Nanotechnology and Molecular Biomedicine Research, School of Sciences
Universidad de las Américas Puebla
San Andrés Cholula, Puebla
México


Miguel A. Méndez-Rojas
Department of Chemical & Biological Sciences and Laboratory of Nanotechnology and Molecular Biomedicine Research, School of Sciences
Universidad de las Américas Puebla
San Andrés Cholula, Puebla
México


Meran Keshawa Ediriweera
Institute of Biochemistry, Molecular Biology and Biotechnology
University of Colombo, 90, Cumaratunga Munidasa Mawatha
Colombo 03
Sri Lanka


Megha Gautam
Jaypee Institute of Information Technology, A-10, Sector 62
Noida, Uttar Pardesh
India


Mehak Aggarwal
Jaypee Institute of Information Technology, A-10, Sector 62
Noida, Uttar Pardesh
India


Manish K Sharma
Pioneer Center of Biosciences, Mohan Nagar
Ghaziabad, Uttar Pardesh
India


Priyanka Maurya
Department of Pharmaceutical Sciences
Babasaheb Bhimrao Ambedkar University
Lucknow
India


Peramaiyan Rajendran
Department of Biological Sciences
College of Science, King Faisal University, Hufouf, Al Hassa
Saudi Arabia


Palanisamy Arulselvan
Scigen Research & Innovation
Periyar Technology Business Incubator, Periyar Nagar, Vallam, Thanjavur
Tamilnadu
India
/
Muthayammal Centre for Advanced Research
Muthayammal College of Arts and Science, Rasipuram, Namakkal
Tamilnadu
India


Ravi Kaushik
ICMR-National Institute of Cancer Prevention and Research
Noida, Uttar Pradesh
India


Reema Gabrani
Jaypee Institute of Information Technology, A-10, Sector 62
Noida, Uttar Pardesh
India


Sameera Ranganath Samarakoon
Institute of Biochemistry, Molecular Biology and Biotechnology
University of Colombo, 90, Cumaratunga Munidasa Mawatha
Colombo 03
Sri Lanka


Samipta Singh
Department of Pharmaceutical Sciences
Babasaheb Bhimrao Ambedkar University
Lucknow
India


Saumya Singh
Jaypee Institute of Information Technology, A-10, Sector 62
Noida, Uttar Pardesh
India


Shweta Dang
Jaypee Institute of Information Technology, A-10, Sector 62
Noida, Uttar Pardesh
India


Shubhini A. Saraf
Department of Pharmaceutical Sciences
Babasaheb Bhimrao Ambedkar University
Lucknow
India


Thamaraiselvan Rengarajan
Scigen Research & Innovation
Periyar Technology Business Incubator, Periyar Nagar, Vallam, Thanjavur
Tamilnadu
India




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