Chapter 8

miRNA and Nanoparticle Conjugate as a Future Therapeutic Approach

Rituparna Acharya

Abstract

Micro RNAs are naturally occurring RNA molecules that help in the degradation of mRNA molecules sequence specifically. They degrade the mRNA molecules and thus inhibit the formation of protein after translation. miRNA expression varies from tissue to tissue and from one disease condition to other. Thus this molecule becomes a target of therapy in various types of disease conditions. But, the use of bare miRNAs has several drawbacks as they may degrade in the body fluid due to their fragile nature. So, in this regard nanoparticles have a very vital role to overcome these disadvantages. In this study, we intended to discuss the various forms of miRNA therapeutic approaches, along with various types of nanoparticles that may carry the miRNA and its antagomirs to the target site.

Total Pages: 117-134 (18)

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