Editor: Atta-ur-Rahman

Frontiers in Clinical Drug Research-Anti-Infectives

Volume 5

eBook: US $79 Special Offer (PDF + Printed Copy): US $158
Printed Copy: US $119
Library License: US $316
ISSN: 2452-3208 (Print)
ISSN: 2352-3212 (Online)
ISBN: 978-1-68108-638-5 (Print)
ISBN: 978-1-68108-637-8 (Online)
Year of Publication: 2019
DOI: 10.2174/97816810863781190501

Introduction

Frontiers in Clinical Drug Research – Anti infectives is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the book series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents.

Frontiers in Clinical Drug Research – Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology.

The fifth volume of this series features six reviews:

  • - Integrated Approaches for Marine Actinomycete Biodiscovery
  • - Therapeutic Use of Commensal Microbes: Fecal/Gut Microbiota Transplantation
  • - Alternative Approaches to Antimicrobials
  • - Nanoantibiotics: Recent Developments and Future
  • - Cranberry Juice and Other Functional Foods in Urinary Tract Infections in Women: A Review of Actual Evidence and Main Challenges
  • - Targeting Magnesium Homeostasis as Potential Anti-Infective Strategy Against Mycobacteria

Preface

The 5th volume of Frontiers in Clinical Drug Research – Anti Infectives comprises six chapters that cover a variety of topics including prolonging antibiotic life, biofilms in medical devices and various antiviral drugs.

In chapter 1, Kurtböke et al. present an overview of new bioactive compound and marine actinomycetes that might be further exploited for their potential as novel and potent drug candidates. In chapter 2, Zárate-Bladés et al. have reviewed the developments in the field of pathogenesis of Clostridium difficile infections and clinical and experimental studies on the therapeutic effects of gut microbial transportation (GMT) against recurrent C. difficile infections (CDI). The methodology of gut microbial transportation (GMT) and applications in the context of the mechanisms of microbiota effects on the immune system are also discussed.

Chapter 3 by Filazi & Yurdakok-Dikmen presents an insight into antimicrobials, particularly against direct-food microbes, as well as other alternative products such as plant-derived compounds, bacteriophage and phage lysins, and antimicrobial peptides. They also discuss novel approaches applicable in the field. In chapter 4, Ahmad et al. explain the current status of different nanoantibiotic (nAbts) loaded systems, their release mechanisms, key targets, formulations and modes of action. Important features of nanoantibiotics (nAbts) such as size, surface charge, hydrophobicity/philicity, biofilm formation, stimuli-receptive and functionalization against multidrug-resistant (MDR) pathogens are also described.

In chapter 5, Monroy-Torres & Medina-Jiménez present primary objectives of cranberry and other functional foods in urinary tract infections in women. Chapter 6 by Hameed & Fatima discusses insights into the association of Magnesium (Mg2+) in survival of Myobacterium Tuberculosis (Mtb) and how it can be exploited as an anti-mycobacterial drug target.

I would like to thanks all the authors for their excellent contributions that will be of great interest. I would also like to thank the editorial staff of Bentham Science Publishers, particularly Mr. Zain Rehman, Mr. Shehzad Naqvi and Mr. Mahmood Alam for their support.

Prof. Atta-ur-Rahman, FRS
Honorary Life Fellow,
Kings College,
University of Cambridge,
Cambridge
UK

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