Foreword

The sixth volume of Topics in Anti-Cancer Research presents some exciting contributions in frontier areas of anti-cancer research. These include the role of microtubules for the treatment of various cancers, novel chemoimmunotherapy drug combinations & methods in clinical studies/trial and current studies in targeting polyunsaturated fatty acids (PUFAs) in the treatment of colorectal cancer. Natural and synthetic chalcones and their derivatives that have shown potent anticancer activity against a number of cancer cell lines and murine tumor models are discussed. The discovery of selective small-molecule hLDH-A inhibitors and LDH-based approaches in the progress of anticancer therapy are also presented. Recent advances in microRNA-based cancer therapeutics for the treatment of cancer are presented. The role of inflammation in chemotherapy-induced neuromuscular effects and the side effects and recent relevant patents for beneficial approaches to improve heart failure cases due to inflammation, mitochondria and energy metabolism in cancer cachexia are also covered. It is hoped that the present volume will be found useful by a large number of scientists working in this field.

The editors are thankful to the authors for their excellent contributions and to the reviewers for their in -depth comprehensive comments for the improvement of chapters. We are also grateful to Mr. Mahmood Alam, Mrs. Rafia Rehan and other colleagues for their support and assistance in the finalization of this volume.