Editors: María Victorina Aguilar Vilas, Cristina Otero Hernandez

Series Title: Frontiers in Bioactive Compounds

At the Crossroads between Nutrition and Pharmacology

Volume 2

eBook: US $149 Special Offer (PDF + Printed Copy): US $253
Printed Copy: US $179
Library License: US $596
ISSN: 2468-6395 (Print)
ISSN: 2468-6409 (Online)
ISBN: 978-1-68108-430-5 (Print)
ISBN: 978-1-68108-429-9 (Online)
Year of Publication: 2017
DOI: 10.2174/97816810842991170201


Functional foods (foods with known bioactive properties) have shown potential for preventive and therapeutic treatments. However, this potential must be safely determined before they enter the commercial market. At the same time, nutrition research is transforming into a data driven field with reference to the identification and development of functional food products due to the large number of variables affecting food biochemistry in the human body. This volume presents reviews of recent advances in food chemistry, food technology and nutraceutical research (for diet therapy and cosmetics).

Chapters in this volume cover a broad spectrum of topics:

  • - drug discovery and development in the modern nutraceutical industry,
  • - recent developments in the extraction, identification and quantification of bioactive peptides in foods,
  • - concepts of bioavailability, bioaccessibility, bioactivity, bioefficiency and bioconversion of bioactive foods,
  • - synthetic routes for obtaining bioactive compounds,
  • - the role of nutrigenomics to identify key cellular functions by specific genetic and epigenetic interactions with a nutrient,
  • - anti-cancer properties of important bioactive components of medicinal plants,
  • - the effect of a diet based on different bioactive foods on prevention and treatment of diabetes,
  • - antioxidant effects on cardiovascular disease,
  • - beneficial effects of bioactive foods on metabolic syndrome,
  • - the potential of tauroursodeoxycholic acid on prevention and recovery of neurodegenerative diseases,
  • - the effects of natural phytochemicals in prostate cancer,
  • - the effects of methylxanthines (caffeine and others), and culinary methods on physiological and toxicological effects of the bioactive food constituents.

The volume is an ideal reference for pharmacy students, nutritionists, healthcare providers and nutraceutical R&D specialists interested in functional foods.


- Pp. i
Philip C. Calder
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Preface 1

- Pp. ii-iv (3)
Cristina Otero
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Preface II

- Pp. v
Victorina Aguilar
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List of Contributors

- Pp. vi-vii (2)
M. Victorina Aguilar, Cristina Otero
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From Pharma to Food: Mechanistic Target Identification for Bioactive Compounds Using Nutritional Systems Biology

- Pp. 3-23 (21)
Erfan Younesi
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Advances in the Determination of Bioactive Peptides in Foods

- Pp. 24-53 (30)
Patrycja Puchalska, Maria Concepción García, Maria Luisa Marina
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Overview of In vivo and In vitro Methods for Assessing Bioavailability of Bioactive Food Compounds

- Pp. 54-98 (45)
Antonio Cilla, Reyes Barberá, Amparo Alegría
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Novel Nutrigenomics Avenues in Nutraceuticals Use: The Current Status of Fermented Papaya Preparation

- Pp. 99-123 (25)
Amelie Mantello, Roberto Catanzaro, Fang He, Biagio Cuffari, Laura Bissi, Michele Milazzo, Aldo Lorenzetti, Francesco Marotta
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Bioactive Properties of Sugar Fatty Acid Esters

- Pp. 124-145 (22)
Ran Ye, Douglas G. Hayes
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Arabinoxylans: Bioactivities in Relation to Their Molecular Structure

- Pp. 146-164 (19)
Weili Li, Zhengxiao Zhang, Christopher Smith
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Yam (Dioscorea species): Future Functional Wild Food of Tribal Odisha, India

- Pp. 165-185 (21)
Sanjeet Kumar
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Biological and Medical Effects of Saponins of Hedera helix and Other Medicinal Plants

- Pp. 186-199 (14)
Yuriy G. Shckorbatov
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Bioactive Compounds and Diabetes

- Pp. 200-229 (30)
Miriam Román Menacho, Domingo Ly Pen, Antonio Becerra Fernández
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Evidence to the Vitamin E and Other Antioxidants Influencing Cardiovascular Diseases

- Pp. 230-263 (34)
Antonio Becerra-Fernández, Miriam Menacho Román, Domingo Ly Pen
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Metabolic Syndrome and Bioactive Compounds

- Pp. 264-292 (29)
Domingo Ly Pen, Antonio Becerra, Miriam Menacho
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Urso-, Glycoursodeoxycholic and Tauroursodeoxycholic Acids: From Basic Research to Clinical Applications in CNS Disorders

- Pp. 293-325 (33)
Dora Brites
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Bioactive Compounds and Prostate Cancer Therapy

- Pp. 326-356 (31)
Sofia M. Yartseva, Yan A. Ivanenkov
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Health Effects and Risks of Caffeine, Theobromine and Theophylline

- Pp. 357-382 (26)
Antonio Peña-Fernández, Mark D. Evans, Avninder S. Bhambra
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Effect of Cooking on the Bioactive Compounds

- Pp. 383-411 (29)
Cristina Garcia-Viguera, Cristina Soler-Rivas
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Subject Index

- Pp. 412-418 (7)
M. Victorina Aguilar, Cristina Otero
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.Botanicals and Natural Bioactives: Prevention and Treatment of Diseases.
.Frontiers In Medicinal Chemistry.
.Alkaloids and Other Nitrogen-Containing Derivatives.
.Potential Health Benefits of Biologically Active Peptides Derived from Underutilized Grains: Recent Advances in their Isolation, Identification, Bioactivity and Molecular Analysis.