Editors: Atta-ur-Rahman, FRS , M. Iqbal Choudhary

Anti-Angiogenesis Drug Discovery and Development

Volume 4

eBook: US $89 Special Offer (PDF + Printed Copy): US $176
Printed Copy: US $131
Library License: US $356
ISSN: 2452-3240 (Print)
ISSN: 2210-268X (Online)
ISBN: 978-1-68108-398-8 (Print)
ISBN: 978-1-68108-397-1 (Online)
Year of Publication: 2019
DOI: 10.2174/97816810839711170401


The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

This volume brings together 7 reviews on the following topics:

  • - Retinal angiogenesis
  • - Effects of brief daily EMF therapy on tumor growths
  • - Evolution of the role of angiogenesis in cancer treatments over six decades
  • - Anti-angiogenesis drugs
  • - Anti-angiogenesis therapy for multiple sclerosis
  • - Update on the link between angiogenesis and portal hypertension


- Pp. i
Atta-ur-Rahman, M. Iqbal Choudhary
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List of Contributors

- Pp. ii-iii (2)
Atta-ur-Rahman, M. Iqbal Choudhary
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Retinal Angiogenesis: Towards a Cure

- Pp. 1-18 (18)
Rachel M. Knott

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Cancerous Tumor Growth, Driven by Hypoxia Induced Angiogenesis is Slowed by Brief Daily EMF Therapy

- Pp. 19-33 (15)
Ivan Cameron

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Angiogenesis in Cancer Treatment: 60 Years’ Swing Between Promising Trials and Disappointing Tribulations

- Pp. 34-96 (63)
Khalid Alhazzani, Ali Alaseem, Mohammad Algahtani, Sivanesan Dhandayuthapani, Thiagarajan Venkatesan, Appu, Rathinavelu

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Anti-Angiogenesis Drugs: Hopes and Disappointments in Certain Cancers

- Pp. 97-107 (11)
Georgios M. Iatrakis

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Anti-Angiogenic Therapy for Retinal Diseases

- Pp. 108-136 (29)
Mitzy E. Torres Soriano, Jesica Dimattia, Maximiliano Gordon
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Molecular Targets of Angiogenesis and Future Potential of Anti-angiogensis Therapy in Multiple Sclerosis

- Pp. 137-161 (25)
Manisha J. Oza, Sachin V. Suryavanshi, Mayuresh S. Garud, Sandip T. Auti, Ankit P. Laddha, Yogesh A. Kulkarni

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Angiogenesis and Portal Hypertension: An Update

- Pp. 162-218 (57)
Dmitry Victorovich Garbuzenko, Nikolay Olegovich Arefyev, Evgeniy Leonidovich Kazachkov

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Subject Index

- Pp. 219-228 (10)
Atta-ur-Rahman, M. Iqbal Choudhary
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