Chapter 8

Troubles and Efficiency of aDNA

Marc Simon and Assumpcio Malgosa


From the establishment of a first set of authenticity criteria to their progressive improvement in parallel with this field’s technology advances, the fight to overcome contamination has not ceased over the years. On its part, another problem at the time of recovering ancient genetic material can be caused by properties which may be inherent to the samples, as well as by their interaction with the elements where they are located. A summary from the evolution in these factors’ knowledge and the solutions that scientists have given them before the arrival of next-generation sequencing techniques is provided. Finally, a thorough description of the tissues from which ancient genetic material is recovered and the developments to do so from different source organisms is provided.

Total Pages: 160-182 (23)

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.Sperm-Mediated Gene Transfer: Concepts and Controversies.
.The Analysis of Regulatory DNA: Current Developments, Knowledge and Applications Uncovering Gene Regulation
.Probing Intracellular Regulation.