Editors: Puneetpal Singh, Monica Singh

Pain: Causes, Concerns and Consequences

eBook: US $29 Special Offer (PDF + Printed Copy): US $127
Printed Copy: US $113
Library License: US $116
ISBN: 978-1-68108-372-8 (Print)
ISBN: 978-1-68108-371-1 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810837111160101


Pain is a significant medical problem, as it is a factor in many diseases and debilitating conditions. The processing of pain in the body is a complex process which involves nerve signaling in the milieu of biochemical, molecular and genetic interactions occurring in the brain and other parts of the body. Pain, as a spokesperson of real and impending injury, outlives its usefulness as a warning signal and instead becomes chronic and excruciating. The transition of the realization of pain up to the cortical processing as a persistent condition represents an intricate process governed by the interaction of various factors. Research on humans and animals has led to the advent of personalized medicine where every patient can be treated according to the set of genes they possess. However, the genetic basis for pain has largely been undefined so far. Research on epigenetic alterations and micro-RNA (miRNA) in relation to the assessment and prevention of pain is still in infancy.

Pain: Causes, Concerns and Consequences focuses on pain in human diseases such as cardiac and non-cardiac disorders. This compendium on pain research offers basic information and useful updates on the pathology, genetics, and biomolecular pathways that cause pain. Additionally, readers will also learn about non-pharmacological therapies for pain. The monograph is a handy guide for medical students and doctors in different divisions such as oncology, surgery, neurology, psychiatry, psychology, physiotherapy and chiropractic care. The book also serves as a guide for life science researchers who are planning to develop methods to study pain in either a clinical or laboratory setting.


- Pp. i-iii (3)
Puneetpal Singh, Monica Singh
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List of Contributors

- Pp. iv
Puneetpal Singh, Monica Singh
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Pain: A Clinician's Journey

- Pp. 3-16 (14)
David S. Basser
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Functional Brain Circuitry in Central Post-stroke Pain

- Pp. 17-39 (23)
Andrew Chih Wei Huang, Hsiang-Chin Lu, Bai Chuang Shyu
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The Role of Psychological Factors in Cardiac and Non-Cardiac Chest Pain

- Pp. 40-72 (33)
Masoumali Masoumi, Mozhgan Saeidi, Saeid Komasi
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Genetic Explorations of Pain

- Pp. 73-110 (38)
Harjot Dhillon, Puneetpal Singh
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Non-Pharmacological Treatment Options for Coexisting Chronic Non-Cancer Pain and Substance Use Disorder

- Pp. 111-125 (15)
Peter Przekop
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MicroRNAs: The Tiny Robust Players Unraveling the Multifaceted Channels of Pain

- Pp. 126-160 (35)
Yogita K. Adlakha
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The Ameliorative Potential of 7-Hydroxy- 4-Methylcoumarin in Acrylamide Induced Neuropathic Pain via Improving of Mitochondrial Function in Rat

- Pp. 161-187 (27)
Jaspreet Kaur, Arunachalam Muthuraman, Muthusamy Ramesh
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Subject Index

- Pp. 188-198 (11)
Puneetpal Singh, Monica Singh
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.Aromatherapy: The Science of Essential Oils.
.Steroids and their Medicinal Potential.
.An Introduction to Mycosporine-Like Amino Acids.
.Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases.