Preface

Frontiers in Clinical Drug Research - Anti Allergy Agents (Volume 3) comprises five comprehensive chapters on various treatment strategies for allergic conditions. In chapter 1, Cundell and Mickle focus on the existing different generations of drugs and the development of more potent anti-histamines. In the second chapter, Gonzalez-Estrada and Fernandez discuss the common drugs used for managing Chronic Spontaneous Urticaria, their side effects, and monitoring parameters. Both Ca²⁺ dynamics and Ca²⁺ sensitization are responsible for alterations in contractility in airway smooth muscle cells that lead to conditions of asthma and chronic obstructive pulmonary disease (COPD). Hiroaki Kume in chapter 3 of this book explain that the Ca²⁺ dynamics and Ca²⁺ sensitization may be the therapeutic approaches for treating asthma and COPD, and research in these areas may provide novel strategies for the development of bronchodilators for these diseases that will be effective for both bronchoconstriction and airway inflammation. In the next chapter Cingi et al. review the effects of Allergic Rhinitis on communication skills mainly in three categories: physiological, psychological and behavioral. In the last chapter, Bajpai et al. present the role of Endosomal Toll-like Receptors in inflammation and related diseases. They focus on the structural features of Toll-like Receptors, specific ligands, intracellular signaling and the role of Endosomal TLRs in the aggravation of diseases.

I hope that this volume will be of great interest to the scientific community and will play a vital role in the development of more effective therapeutic agents to combat various pulmonary ailments.

I would like to thank all the authors and the excellent team of Bentham Science Publishers, especially Dr. Faryal Sami, Mr. Shehzad Naqvi and Mr. Mahmood Alam for their support and hardwork.