Editors: Atta-ur-Rahman , M. Iqbal Choudhary , Allen B. Reitz

Frontiers in Medicinal Chemistry

Volume 8

eBook: US $99 Special Offer (PDF + Printed Copy): US $168
Printed Copy: US $119
Library License: US $396
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)
ISBN: 978-1-68108-176-2 (Print)
ISBN: 978-1-68108-175-5 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810817551160801

Introduction

“Frontiers in Medicinal Chemistry” is an eBook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines.

“Frontiers in Medicinal Chemistry” covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. This eBook series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.

This volume features reviews on the following topics:

- ADME optimization and toxicity assessment in drug discovery

- Targeting oxidative stress mechanisms in vascular disease therapy

- Diabetes therapy that targets endothelial function

… and more.

Indexed in: Book Citation Index, Science Edition, Web of Science, BIOSIS Previews, EMBASE, Chemical Abstracts, EBSCO., Ulrich's Periodicals Directory.

Preface

- Pp. i
Atta-ur-Rahman, M. Iqbal Choudhary and Allen B. Reitz
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Contributors

- Pp. ii-iv (3)
Atta-ur-Rahman, M. Iqbal Choudhary and Allen B. Reitz
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ADME Optimization and Toxicity Assessment in Drug Discovery

- Pp. 3-60 (58)
Gary W. Caldwell

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The Oxidative Stress Menace to Coronary Vasculature: Any Place for Antioxidants?

- Pp. 61-95 (35)
Alexandros Briasoulis, Charalampos Antoniades, George-Angelo Papamikroulis, Evangelos Oikonomou and Dimitris Tousoulis

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Atherosclerosis, Mitochondrial Dysfunction and Oxidative Stress: Mitochondria-Targeted Antioxidants as Potential Therapy

- Pp. 96-135 (40)
Irene Escribano-Lopez, Noelia Diaz-Morales, Susana Rovira-Llopis, Celia Bañuls, Sandra Lopez-Domenech, Raquel Castelló, Rosa Falcón, Eva Sola, Milagros Rocha, Antonio Hernández-Mijares and Victor M. Víctor

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Endothelial Dysfunction in Diabetes: An Update on Mechanisms and Therapeutic Targets

- Pp. 136-170 (35)
Maria Assunta Potenza, Carmela Nacci, Luca Sgarra, Valentina Leo, Maria Antonietta De Salvia and Monica Montagnani
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Pyridinium Oximes as Cholinesterase Reactivators. An Update of the Structure-Activity Relationship and Efficacy in the Treatment of Poisoning with Organophosphorus Compounds

- Pp. 171-205 (35)
Milan Jokanović and Radica Stepanović Petrović

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Calixarenes in Biotechnology and Bio-Medical Research

- Pp. 206-301 (96)
Roman V. Rodik, Vyacheslav I. Boyko and Vitaly I. Kalchenko

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Index

- Pp. 302-314 (13)
Atta-ur-Rahman, M. Iqbal Choudhary and Allen B. Reitz
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