Editors: Manuela Oliveira, Isa Serrano

Series Title: Frontiers in Antimicrobial Agents

The challenges of antibiotic resistance in the development of new therapeutics

Volume 1

eBook: US $99 Special Offer (PDF + Printed Copy): US $168
Printed Copy: US $119
Library License: US $396
ISSN: 2452-2570 (Print)
ISSN: 2452-2589 (Online)
ISBN: 978-1-68108-141-0 (Print)
ISBN: 978-1-68108-140-3 (Online)
Year of Publication: 2015
DOI: 10.2174/97816810814031150101


The addition of only two novel classes of antibiotics to fight drug resistant microorganisms in the clinic over the past three decades means that the quest for new molecules that are effective against the threat of drug resistance is now a significant issue in modern medicine. Researchers have begun to experiment on alternative therapies to combat this threat.

Novel chemical agents are considered to be drugs of choice for tomorrow's clinical practice owing to their low probability to generate resistance. The first volume of Frontiers in Antimicrobial Agents describes innovative alternatives to the classical antimicrobial therapeutics, such as phage therapy, AMPs, probiotics, novel biocides, natural products and immunotherapy. Cutting-edge research is brought to the forefront, shedding light on the developments taking place to meet the challenge of drug resistant microorganisms. The volume also features information on antimicrobial approaches in veterinary medicine.

The book is a useful reference for researchers, microbiologists and healthcare professionals interested in updates on antibiotic resistance and alternatives to classical antibiotic therapy.


- Pp. i
João João Mendes
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- Pp. ii-iii (2)
Manuela Oliveira, Isa Serrano
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List of Contributors

- Pp. iv-v (2)
Manuela Oliveira, Isa Serrano
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- Pp. 3-9 (7)
Manuela Oliveira, Amélia Fernandes, Isa Serrano
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Bacteriophages as Antibacterial Agents: Why are We Facing an Antibiotic Crisis and How Could Bacteriophages be of Help?

- Pp. 10-32 (23)
Jean-Paul Pirnay, Gilbert Verbeken, Mario Vaneechoutte, Serge Jennes, Maya Merabishvili, Isa Serrano, Daniel De Vos
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Antimicrobial Peptides

- Pp. 33-68 (36)
Isa Domingues Serrano
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Probiotics: Ways of Action and Beneficial Effects

- Pp. 69-96 (28)
Nabil Benomar, Hikmate Abriouel, Rubén Pérez Pulido, Leyre Lavilla Lerma, María del Carmen Casado Muñoz, Antonio Gálvez
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- Pp. 97-148 (52)
Solange Gil, Dias J., Lourenço A.M., Leal R., Tavares L.
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Perspectives on Natural Products

- Pp. 149-177 (29)
Ana Patrícia Quendera, Teresa Semedo-Lemsaddek
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- Pp. 178-207 (30)
Sara Correia Santos, Manuela Oliveira, Teresa Semedo Lemsaddek
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Biocides – A Reasonable Alternative to Prevent and Control Microorganisms?

- Pp. 208-233 (26)
Rui Seixas, Carla Mottola
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Novel Therapeutic Strategies in Veterinary Medicine

- Pp. 234-260 (27)
Ana Duarte, Luis Tavares
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- Pp. 261-262 (2)
Manuela Oliveira, Isa Serrano
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Subject Index

- Pp. 263-266 (4)
Manuela Oliveira, Isa Serrano
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.Emerging Approaches to Tackle Neglected Diseases: From Molecule to End Product.
.COVID 19 – Monitoring with IoT Devices.
.Recent Advances in the Application of Marine Natural Products as Antimicrobial Agents.
.Recent Trends and The Future of Antimicrobial Agents - Part 2.