Author: Robert E. Smith

Medicinal Chemistry - Fusion of Traditional and Western Medicine, Second Edition

eBook: US $89 Special Offer (PDF + Printed Copy): US $217
Printed Copy: US $173
Library License: US $356
ISBN: 978-1-60805-975-1 (Print)
ISBN: 978-1-60805-974-4 (Online)
Year of Publication: 2014
DOI: 10.2174/97816080597441140201

Introduction

Medicinal Chemistry - Fusion of Traditional and Western Medicine is a textbook intended for students taking courses in the various fields of medicinal chemistry, pharmacy, medical and dental programs. Moreover, people working in the pharmaceutical industry and doctors preparing for Medical Board Exams will also find it useful. Since, new drugs are being developed by multi-disciplinary teams; this E-Book describes new paradigms that are emerging in modern biology, biochemistry and medicine. It is therefore a fusion of traditional and western medicine and between systems thinking and reductionist thinking. Readers will learn about how new drugs are investigated, developed and eventually approved by the FDA. The book also includes important information about cGMP, GLP and the FDA regulatory requirements, the importance of environmental toxins, such as bisphenol A (BPA) and perfluorooctanoic acid (PFOAA) in autoimmune diseases and health. This book offers exceptional value in its descriptions of RNA, epigenetics, toxicology, new drug development, genetically modified organisms and analytical chemistry that cannot be found in other textbooks.

Indexed in: Book Citation Index, Science Edition, EBSCO.

Preface

This book was written as a textbook for the first semester in a two-semester a course in medicinal chemistry that is taught in most pharmacy schools. It can be used in standard courses for pharmacy students and for students who are trying to get into medical, dental, pharmacy or graduate school. “Moreover, people working in the pharmaceutical industry and doctors preparing for Medical Board Exams will also find it useful” [1]. “Since new drugs are being developed by multi-disciplinary teams, this book” [1] has a multi-disciplinary approach. Chemists, biologists, physicians, mathematicians, engineers and computer scientists will read some things that are familiar to them and they will learn about each other’s disciplines. It describes the new paradigm that is “emerging in modern biology, biochemistry and medicine. It is a fusion of traditional and western medicine and between systems thinking and reductionist thinking” [1]. The important newly discovered roles of epigenetics and different types of RNA are discussed at length. This edition tells “how new drugs are investigated, developed and eventually approved by the FDA” [1]. Although most currently approved drugs were developed based on their abilities to affect a single therapeutic target, new drugs will affect many targets simultaneously. Instead of binding to the active site of a single enzyme, allosteric inhibitors will partially inhibit many targets simultaneously and have far fewer harmful side effects. It also talks about high throughput screening and data mining to look for new chemical entities that might become new drugs. The chapter on pharmacokinetics and toxicokinetics has been expanded, as have other chapters. Drugs that target enzymes, membrane bound receptors, DNA, microtubules, RNA, ion pumps and transporters are described, along with ways to improve the lead compound through rational drug design. The book talks about cGMP, GLP and the regulatory process. It describes the analytical methods that are used to verify that the right drug has been made and that no impurities are present. It also has chapters on toxicology, nutrition and dietary supplements. Finally, this book and the topics discussed in it should not be taken as reflecting FDA policy or regulations.

ACKNOWLEDGEMENTS

Declared none.

CONFLICT OF INTEREST

The author confirms that this ebook contents have no conflict of interest.

REFERENCE

[1] Smith RE. Medicinal Chemistry – Fusion of Traditional and Western Medicine. Bentham Science. Sharjah, UAE, 2013.

Robert E. Smith
Park University
Chemistry Department
8700 NW River Park Drive Parkville, MO 64152
USA
Email: Robert.Smith05@park.edu

RELATED BOOKS

.Science of Spices and Culinary Herbs - Latest Laboratory, Pre-clinical, and Clinical Studies.
.Science of Spices and Culinary Herbs - Latest Laboratory, Pre-clinical, and Clinical Studies.
.Medicinal Chemistry of Drugs Affecting the Nervous System.
.Advances in Anticancer Agents in Medicinal Chemistry.