Editors: Atta-ur-Rahman , M. Iqbal Choudhary

Frontiers in Cardiovascular Drug Discovery

Volume 2

eBook: US $59 Special Offer (PDF + Printed Copy): US $148
Printed Copy: US $119
Library License: US $236
ISSN: 2452-3267 (Print)
ISSN: 1879-6648 (Online)
ISBN: 978-1-60805-969-0 (Print)
ISBN: 978-1-60805-968-3 (Online)
Year of Publication: 2015
DOI: 10.2174/97816080596831150201

Introduction

Frontiers in Cardiovascular Drug Discovery is an eBook series devoted to publishing the latest and the most important advances in Cardiovascular drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in cardiovascular drug design and discovery. Each volume is devoted to the major advances in cardiovascular drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Indexed in: Book Citation Index, EMBASE, Chemical Abstracts, EBSCO.

Preface

Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Atherosclerosis, hypertension, diabetes, obesity and age-related physiological and morphological changes, along with diet, stress, alcohol consumption and smoking are among the most important risk factors of cardiovascular diseases. Despite major developments in the prevention and management of cardiovascular diseases, over 20% of all global deaths are attributed to cardiovascular diseases as existing treatments are far from ideal. The recently established link between low-grade inflammation, due to atherosclerosis, obesity and infection, has led to the identification of several new targets for drug discovery and development. In brief the need of both effective treatment and prevention strategies, as well as a better understanding of risks and progress of disease at the molecular level, is greatly felt.

Volume 2 of the book series “Frontiers in Cardiovascular Drug Discovery” is a compilation of four excellent reviews, contributed by established researchers in the field.

Dingguo et al. have reviewed the cardioprotective effects of medicinal herbs used in traditional Chinese medicines, along with dietary nutritional supplements, and other natural products.

The second review, contributed by Alexander et al., also focuses on natural products. It discusses the results of studies of various agents on atherosclerosis is highlighted. The importance of natural products as primary preventive therapy for atherosclerosis. These natural products were found to be as effective as conventional drugs used in the regression of carotid atherosclerosis, and are more appropriate in the long term treatment of vascular disorders. The discovery of natural compounds as anti-atherosclerotic agents with limited side effects may lead to a novel therapeutic strategy against atherosclerosis prophylaxis.

Tatjana et al. present a brief summary of key findings achieved with new oral anticoagulants, including thrombin and factor Xa inhibitors, for the prevention of stroke in arterial fibrillation. These oral anticoagulants are superior to existing oral vitamin K antagonists in terms of rapid action, dose-related anticoagulant effect, lower drug-drug interactions, and do not need regular laboratory monitoring. Furthermore, these novel oral anticoagulants have exhibited remarkable efficacy in various phase III randomized trials.

Modulation of the sympathetic nervous system plays an important role in hypertension. In the last chapter by Doltra et al., the authors have discussed the results of animal studies and clinical trials on radiofrequency based sympathetic nerve modulation. Pathophysiological and technical aspects of this emerging treatment is discussed in this review.

We expect that this excellent compilation of well written scientific articles will contribute in updating the knowledge of researchers in academic and R&D institutions working in this important field. We wish to thank the contributing authors for presenting exciting state-of-the-art accounts in this field, and for providing a critical analysis of various new treatments and prevention regimen commentaries. We also profoundly appreciate the efforts and skills of the editorial staff, particularly Mr. Mahmood Alam (Director Publication) and Ms. Sara Yaser (Manager Publications), for bringing the second volume in a timely and most efficient manner.

Prof. Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

Prof. M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi
Karachi
Pakistan