Editor: Elísio Costa

Series Title: Frontiers in Drug Discovery

Erythropoietic Stimulating Agents

Volume 1

eBook: US $89 Special Offer (PDF + Printed Copy): US $163
Printed Copy: US $119
Library License: US $356
ISSN: 2542-7350 (Print)
ISSN: 2214-6210 (Online)
ISBN: 978-1-60805-748-1 (Print)
ISBN: 978-1-60805-747-4 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080574741130101

Introduction

The development of new erythropoietic stimulating agents (ESAs) has significantly increased in recent years. Researchers are focused on different and interesting concepts, namely, methods to increase half-life of erythropoietin (EPO), finding different routes of administration and new ESA or modified EPO molecules. Scientific literature presents evidence that EPO has other effects beyond erythropoietic stimulation. These pleiotropic effects of EPO appear to result from the existence of two different EPO receptors (EPOR) with different affinities for EPO. The discovery of new EPO actions beyond the hematopoietic system has opened a new field of investigation with these agents. Several molecules have been developed to present the protective action, without the activation of the hematopoietic system. These agents can be potentially used in several diseases of the brain/central and peripheral nervous system, eye, heart and kidney.

This volume of Frontiers in Drug Discovery includes a revision of articles on erythropoiesis and EPO gene regulation, microRNAs and their potential contribution to the development of new therapeutic strategies, animal models for studying kidney disease-associated anemia as well as benefits/risks of ESA therapy. The biological effects of new ESA molecules, heparin-binding erythropoietin and of pHBSP, and the potential applications of ESA, are also elicited in this volume.

This volume is, therefore, a useful reference for medicinal chemists and hematologists interested in drug development and medicine related to ESAs.

Foreword

- Pp. i-ii (2)
Rui Alves
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Preface

- Pp. iii-iv (2)
Elísio Costa, Flávio Reis and Alice Santos-Silva
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List of Contributors

- Pp. v-viii (4)
Elísio Costa, Flávio Reis and Alice Santos-Silva
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Erythropoiesis: Cellular and Molecular Implications

- Pp. 3-26 (24)
Susana Coimbra and Alice Santos-Silva

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Modulation of Erythropoietin Gene Expression

- Pp. 27-42 (16)
João C. Fernandes, Flávio Reis, Elísio Costa and Alice Santos-Silva

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miRNAs and Erythropoietic Stimulating Agents: a New Therapeutic Approach

- Pp. 43-60 (18)
Elsa Bronze-da-Rocha

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Animal Models of Kidney Disease-Associated Anemia

- Pp. 61-80 (20)
Patrícia Garrido, Elísio Costa, Alice Santos-Silva and Flávio Reis

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Risks and Benefits Associated with High Therapeutic Doses of Erythropoiesis Stimulating Agents

- Pp. 81-97 (17)
Sandra Ribeiro, Elísio Costa, Flávio Reis and Alice Santos-Silva

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Resistance to Erythropoietic Stimulating Agents in Pre-Dialysis Elderly Patients

- Pp. 98-114 (17)
Ana Cabrita, Ana P. Silva and Pedro L. Neves

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Heparin-Binding Erythropoietin

- Pp. 115-124 (10)
Ken Toba and Masato Moriyama

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Therapeutic Effects of Pyroglutamate Helix B Surface Peptide (pHBSP) in Disease

- Pp. 125-143 (19)
Kiran K. Nandra, Nimesh S.A. Patel and Christoph Thiemermann

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Erythropoietin in Familial Amyloidosis ATTR V30M

- Pp. 144-159 (16)
Idalina Beirão and Paulo P. Costa

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Effects of Erythropoietin in Skin Regeneration and Repair

- Pp. 160-179 (20)
Heiko Sorg, Reto Wettstein, Peter M. Vogt and Yves Harder

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Effects of Erythropoietin on Blood Vessels and the Heart

- Pp. 180-204 (25)
Wolfgang Jelkmann and Steve Elliott
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Erythropoietin and Endothelial Progenitor Cell Therapy after Myocardial Infarction

- Pp. 205-231 (27)
Kamellia R. Dimitrova, Gabriela R. Dincheva and I. Michael Leitman

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Erythropoietin – A Possible Adjunctive Therapy for Cerebral Malaria

- Pp. 232-254 (23)
Casper Hempel and Jørgen A.L. Kurtzhals

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No Effect of Erythropoiesis-Stimulating Agents on Solid Tumour or Lymphoma Progression?

- Pp. 255-270 (16)
Matti Aapro

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Subject Index

- Pp. 271-294 (24)
Elísio Costa, Flávio Reis and Alice Santos-Silva
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