Immunology of Pregnancy 2013

Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a friend (immune cells and molecules are also necessary for successful pregnancy). Leukemia Inhibitory Factor (LIF) when absent, prevents embryo implantation in rodents. From fecundation to parturition, immunity acts as a Janus, required but potentially dangerous. However, the complexity and the diversity of immunity in pregnancy deters many from entering the field. This book will try to give a complete overview of immunity from gametes till parturition, in brief, but with complete chapters and subsections, each written by specialists in the field.

The importance of the topic relies not only on “the riddle of the fetal allograft”, which is per se fascinating, but on its consequences, linked to the development of IVF and in general, Assisted Reproductive Technologies (ART) / Medicine. Since the discovery that there would not be (mammalian) life without LIF, it has become clear that Immune Molecules, and in general, transient post mating inflammatory reactions are required for successful implantation. Disruptions of this process can lead to implantation failure / sterility.

In later stages of pregnancy immunological cells, mostly of the innate immune system, control formation of local spiral arteries. Finally, a state of tolerance establishes itself, whose “break’ leads to immune abortion and the vascular bed is further transformed and enlarged, till delivery, and here again “immunological cytokines” do play a major role and can eventually cause immune mediated abortion.

Failure of, not just, the cytokine and cell recognition mediated dialogue, but also the pre and peri-implantation “preparation of the uterus”, as stated, leads to sterility, early pregnancy loss and recurrent abortions. There is also an increasingly stronger argument to implicate immunology in pre-eclampsia. Further still, immunology is also implicated in the control of local infection, mother to child transmission of pathogens (notably, but not limited to, HIV). Finally, pregnancy is the only known physiological phenomenon where the once named “suppressor T cells,” re-emerge as “regulatory T cells”, and play a cardinal role.

This E-book provides a complete compendium of gynecological immunology, spanning from fecundation to delivery. Topics also include the role of various cell types (such as T regs ad NK cells) in implantation and uterine changes as well as the genetic regulation of immunological processes. As such it will be of interest not only to fundamental and reproductive immunologists, but more importantly, clinicians in obstetrics and gynecology.

Editor(s):

Gérard Chaouat
Hopital Saint Louis Paris
INRA Jouy en Josas
France

Olivier Sandra
Hopital Saint Louis Paris
INRA Jouy en Josas
France

& Nathalie Lédée
Hopital Saint Louis Paris
INRA Jouy en Josas
France

Contributor(s):

Aaron J. Thomas
Department of Animal, Dairy and Veterinary Sciences
Center for Integrated BioSystems
Utah State University
Logan
UT, 84322-4700
USA

Ae-Re Han
Reproductive Medicine, Department of Obstetrics
Gynecology the Chicago Medical School at Rosalind Franklin University of Medicine and Science
North Chicago
IL, 60064
USA

Agnes Bogdan
Department of Medical Microbiology and Immunology
Medical School, Pécs University
Pécs
Hungary

Akitoshi Nakashima
Department of Obstetrics and Gynecology
University of Toyama
Toyama, 930-0194
Japan

Alice Gilman-Sachs
Department of Microbiology and Immunology
Rosalind Franklin University of Medicine and Science
North Chicago
IL, 60064
USA

Alison S Care
Robinson Institute, School of Pediatric and Reproductive Health
University of Adelaide
Adelaide
SA, 5005
Australia

Aureo T. Yamada
Department of Histology and Embryology
Institute of Biology, University of Campinas
Campinas
SP
Brazil

Beata Polgar
Department of Medical Microbiology and Immunology
Medical School, Pécs University, Pécs, Hungary
Héloïse Quillay Regulation of Retroviral Infection Unit
Department of Virology, Institut Pasteur
Paris
France

Charles R. Wira
Department of Physiology and Neurobiology Dartmouth Medical School
One Medical Center Drive Lebanon
NH, 03756
USA

Chiara Agostini
Institute for Maternal and Child Health, IRCCS Burlo Garofolo
Trieste
Italy

Christopher J. Davies
Department of Animal, Dairy and Veterinary Sciences
Center for Integrated BioSystems
Utah State University
Logan
UT, 84322-4700
USA

David A. Clark
Depts. Medicine, Molecular Medicine & Pathology
Obstetrics & Gynecology, Department of Medicine Room 3H1E
Health Sciences Center, McMaster University
1280 Main St West
Hamilton
Ontario, L8S 4K1
Canada
/
and Toronto General Research Institute
101 College St. Mars Tower TMPT East 2-804
Toronto
Ontario, M5G 1L7
Canada
/
And Professor of Immunology, Faculty of Medicine
University of Toronto
Toronto
Ontario
Canada

David J. Sharkey
Robinson Institute, School of Pediatric and Reproductive Health
University of Adelaide
Adelaide
SA, 5005
Australia

Edward E. Winger
Laboratory for Reproductive Medicine and Immunology
San Francisco
CA, 94111
USA

Eliana M. O. Lippe
Department of Pediatrics
Women and Infants Hospital-Warren Alpert Medical School of Brown University
Providence
Rhode Island
USA

Elisabeth Menu
Regulation of Retroviral Infection Unit, Department of Virology
Institut Pasteur. 25 rue du Dr Roux
Paris, 75015
France

Francesco Tedesco
Department of Life Sciences
University of Trieste, via Valerio 28
Trieste, 34127
Italy

Fuller W. Bazer
442D Kleberg Centre Texas A&M University College Station
TX, 77843-2471
USA

Gabriela Barrientos
Medicine University of Berlin
CC12 Internal Medicine and Dermatology
Laboratory of Reproductive Medicine
Berlin
Germany

Georgi Georgiev
Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Sofia
Bulgaria and Placenta-Labor, Department of Obstetrics
University Hospital Jena
Germany

Gérard Chaouat
Director of Research Emeritus
U976 INSERM /UMR 976 CNRS Hôpital Saint Louis
Paris, 75010
France

Guillermina Girardi
The University of Edinburgh MRC Centre for Reproductive Health
The Queen's Medical Research Institute
47 Little France Crescent EH16 4TJ
Edinburgh
United Kingdom

Gustaaf Dekker
Head Women’s and Children’s Division
Lyell McEwin Hospital, University of Adelaide
Haydown Road
Elizabeth
Vale, 5112
South Australia

Heloisa M. Rutigliano
Department of Animal, Dairy and Veterinary Sciences
Center for Integrated BioSystems
Utah State University
Logan
UT, 84322-4700
USA

Ian L. Sargent
Nuffield Department of Obstetrics and Gynecology
University of Oxford
John Radcliffe Hospital
Oxford , OX3 9DU
United Kingdom

Jana Pastuschek
Placenta-Labor, Department of Obstetrics
University Hospital Jena
Germany

Jane L. Reed
Laboratory for Reproductive Medicine and Immunology
San Francisco
CA, 94111
USA

Jennifer H. Southcombe
Nuffield Department of Obstetrics and Gynecology
University of Oxford
John Radcliffe Hospital
Oxford, OX3 9DU
United Kingdom

Joanne Kwak-Kim
Reproductive Medicine, Department of Obstetrics and Gynecology
The Chicago Medical School at Rosalind Franklin University of Medicine and Science
830 West End Court, Suit 400
Vernon Hills
IL, 60061
USA

John E. Schjenken
Robinson Institute, School of Pediatric and Reproductive Health
University of Adelaide
Adelaide
SA, 5005
Australia

Joon W. Kim
Department of Medicine, Division of Rheumatology
North Western University, Feinberg School of Medicine
Chicago
IL, 60611
USA

Julia Szekeres-Bartho
Department of Medical Microbiology and Immunology
Medical School, Pécs University
Pécs
Hungary

Kenneth D. Beaman
Department of Microbiology and Immunology
Rosalind Franklin University of Medicine and Science
North Chicago
IL, 60064
USA

Koji Koyama
Obstetrics and Gynecology, Laboratory of Developmental Biology and Reproduction
Advanced Medical Sciences, Hyogo College of Medicine
Nishinomiya
Japan

Lachlan M. Moldenhauer
Robinson Institute, School of Pediatric and Reproductive Health
University of Adelaide
Adelaide
SA, 5005
Australia

Leonardo Fainboim
Immunogenetics Laboratory, Clinical Hospital, Department of Microbiology and Immunology
School of Medicine, Buenos Aires University, Argentine National Council for Scientific
Technological Research
Argentina

Marie-Thérèse Nugeyre
Regulation of Retroviral Infection Unit
Department of Virology, Institut Pasteur
Paris
France

Marion Duriez
Regulation of Retroviral Infection Unit
Department of Virology, Institut Pasteur
Paris
France

Marta Rodríguez-García
Department of Physiology and Neurobiology Dartmouth Medical School
One Medical Center Drive Lebanon
NH, 03756
USA

Melinda Halasz
Department of Medical Microbiology and Immunology
Medical School, Pécs University
Pécs
Hungary

Mickey V. Patel
Department of Physiology and Neurobiology Dartmouth Medical School
One Medical Center Drive Lebanon
NH, 03756
USA

Mimi Ghosh
Department of Epidemiology and Biostatistics
George Washington University
2100W Pennsylvania Ave
Washington
DC, 20037
USA

Mona Rahmati
U 976 INSERM U976 INSERM /UMR 976
CNRS Saint Louis Hospital
Paris, 75010
France

Mukesh K. Jaiswal
Department of Microbiology and Immunology
Rosalind Franklin University of Medicine and Science
North Chicago
IL, 60064
USA

Nathalie Lédée
U 976 INSERM U976 INSERM /UMR 976
CNRS Saint Louis Hospital
Paris, 75010
France

Norbert Gleicher
Medical Director and Chief Scientist
Center for Human Reproduction
New York
N.Y
USA
/
President. Foundation for Reproductive Medicine
21 East 69th Street
New York
NY, 10021
USA

Ole B. Christiansen
Fertility Clinic 4071, Rigshospitalet, Co penhagen
Department of Obstetrics and Gynecology
Aalborg hospital
Aalborg
Denmark

Olivier Sandra
INRA, UMR1198 Biologie du Développement et Reproduction
F-78352 Jouy-en-Josas, France; ENVA
Maisons Alfort, F-94704
France

Pankaj Suman
Reproductive Cell Biology Laboratory
National Institute of Immunology Aruna Asaf Ali Marg
New Delhi
India

Patricia D. Lima
Department of Histology and Embryology
University of Campinas, Campinas, SP, 2- Department of Cell
Tissue and Developmental Biology, Institute of Biomedical Science
Federal University of Alfenas
MG
Brazil

Petra C. Arck
Laboratory for Experimental Feto-Maternal Medicine
Department of Obstetrics and Foetal Medicine
University Medical Centre Hamburg-Eppendorf
Hamburg
Germany

Philippe Le Bouteiller
INSERM UMR1043, CNRS UMR5282, Université de Toulouse
Centre de Physiopathologie de Toulouse-Purpan
Hôpital Purpan
Toulouse Cedex 3
BP , 3028 31024
France

Pierre-Yves Robillard
Neonatology
Centre Hospitalier Régional Sud-Réunion
BP 350. Saint-Pierre Cedex
Réunion,
France

Raj Raghupathy
Path Department of Microbiology
Faculty of Medicine Kuwait University
Kuwait

Reginald M. Gorczynski
University of Toronto
Toronto
Ontario
Canada

Roberta Bulla
Department of Life Sciences
University of Trieste
Trieste, 34127
Italy

Romain Marlin
Université Bordeaux 2
UMR-CNRS-5164-CIRID
Bordeaux
France

Sandra M. Blois
Medicine University of Berlin, CC12 Internal Medicine and Dermatology
Laboratory of Reproductive Medicine
Berlin
Germany

Sarah A. Robertson
Robinson Institute, School of Pediatric and Reproductive Health
University of Adelaide
Adelaide
SA, 5005
Australia

Satish K. Gupta
National Institute of Immunology Chief, Reproductive Cell Biology Laboratory
National Institute of Immunology Aruna Asaf Ali Marg
New Delhi
India

Satyan Kalkunte
Department of Pediatrics
Women and Infants Hospital-Warren Alpert Medical School of Brown University
Providence
Rhode Island
USA

Shigeru Saito
Department of Obstetrics and Gynaecology
University of Toyama
Toyama, 930-0194
Japan

Stefan Neubeck
Placenta-Labor, Department of Obstetrics
University Hospital Jena
Germany

Surendra Sharma
Department of Pediatrics
Women and Infants Hospital-Warren Alpert Medical School of Brown University
Providence
Rhode Island, 02912
USA

Tania Nevers
Department of Pediatrics
Women and Infants Hospital-Warren Alpert Medical School of Brown University
Providence
Rhode Island
USA

Timothy M. Miller
Department of Microbiology and Immunology
Rosalind Franklin University of Medicine and Science
North Chicago
IL
USA

Tomoko Shima
Department of Obstetrics and Gynecology
University of Toyama
Toyama, 930-0194
Japan

Udo R. Markert
Placenta-Labor, Department of Obstetrics
University Hospital Jena
Germany

Valdemar A. Paffaro Jr
Department of Cell, Tissue and Developmental Biology
Institute of Biomedical Science
Federal University of Alfenas
MG
Brazil

Vikki M. Abrahams
Department of Obstetrics, Gynaecology & Reproductive Sciences
Yale University School of Medicine
310 Cedar Street, LSOG 305C
New Haven
CT, 06510
USA

Yi Lin
Department of Obstetrics and Gynaecology
Institute of Obstetrics and Gynaecology
Renji Hospital
Shanghai, 200001
China

Zheng Shen
Department of Physiology and Neurobiology Dartmouth Medical School
One Medical Center Drive Lebanon
NH, 03756
USA

Bookshelf

Book Categories

What's new

Future Attractions

For Reviewers

For Buyers and Librarians

For Authors and Editors

Marketing Opportunities

Advertising

General Queries