Editors: Gérard Chaouat, Olivier Sandra, & Nathalie Lédée

Immunology of Pregnancy 2013

eBook: US $149 Special Offer (PDF + Printed Copy): US $268
Printed Copy: US $194
Library License: US $596
ISBN: 978-1-60805-734-4 (Print)
ISBN: 978-1-60805-733-7 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080573371130101

Introduction

Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a friend (immune cells and molecules are also necessary for successful pregnancy). Leukemia Inhibitory Factor (LIF) when absent, prevents embryo implantation in rodents. From fecundation to parturition, immunity acts as a Janus, required but potentially dangerous. However, the complexity and the diversity of immunity in pregnancy deters many from entering the field. This book will try to give a complete overview of immunity from gametes till parturition, in brief, but with complete chapters and subsections, each written by specialists in the field.

The importance of the topic relies not only on “the riddle of the fetal allograft”, which is per se fascinating, but on its consequences, linked to the development of IVF and in general, Assisted Reproductive Technologies (ART) / Medicine. Since the discovery that there would not be (mammalian) life without LIF, it has become clear that Immune Molecules, and in general, transient post mating inflammatory reactions are required for successful implantation. Disruptions of this process can lead to implantation failure / sterility.

In later stages of pregnancy immunological cells, mostly of the innate immune system, control formation of local spiral arteries. Finally, a state of tolerance establishes itself, whose “break’ leads to immune abortion and the vascular bed is further transformed and enlarged, till delivery, and here again “immunological cytokines” do play a major role and can eventually cause immune mediated abortion.

Failure of, not just, the cytokine and cell recognition mediated dialogue, but also the pre and peri-implantation “preparation of the uterus”, as stated, leads to sterility, early pregnancy loss and recurrent abortions. There is also an increasingly stronger argument to implicate immunology in pre-eclampsia. Further still, immunology is also implicated in the control of local infection, mother to child transmission of pathogens (notably, but not limited to, HIV). Finally, pregnancy is the only known physiological phenomenon where the once named “suppressor T cells,” re-emerge as “regulatory T cells”, and play a cardinal role.

This E-book provides a complete compendium of gynecological immunology, spanning from fecundation to delivery. Topics also include the role of various cell types (such as T regs ad NK cells) in implantation and uterine changes as well as the genetic regulation of immunological processes. As such it will be of interest not only to fundamental and reproductive immunologists, but more importantly, clinicians in obstetrics and gynecology.

Indexed in: Book Citation Index, Science Edition, EBSCO.

Foreword by Armand Bensussan

- Pp. i-ii (2)
Armand Bensussan
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Foreword by Philippe Kourilsky

- Pp. iii-v (3)
Philippe Kourilsky
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Preface

- Pp. vi-x (5)
Gérard Chaouat
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List of Contributors

- Pp. xi-xvii (7)
Gérard Chaouat
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Introduction

- Pp. xviii-xivii (30)
Gérard Chaouat
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Innate and Adaptive Immunity in the Human Female Reproductive Tract: Bridging the Menstrual Cycle with Pregnancy

- Pp. 3-58 (56)
Charles R. Wira, Mickey V. Patel, Mimi Ghosh, Zheng Shen and Marta Rodríguez-García

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Immunity to Sperm: Auto- and Iso Immunization

- Pp. 59-99 (41)
Koji Koyama

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Contraceptive Vaccines: Past, Present and Future

- Pp. 100-134 (35)
Satish K. Gupta

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Immune Markers of Oocyte and Embryo Quality

- Pp. 135-157 (23)
Nathalie Lédée

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MHC Antigens Expression/ Function at the Embryonic Interface. Part A: Major Histocompatibility Complex Class I Unique Expression in Human Trophoblast: Facts, Questions and Controversies

- Pp. 158-174 (17)
Philippe Le Bouteiller

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Part B: Expression of MHC-I Proteins by the Placenta of Domestic and Laboratory Animals

- Pp. 175-200 (26)
Heloisa M. Rutigliano, Aaron J. Thomas and Christopher J. Davies

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Immunology of Implantation, Implantation Failure and Pregnancy. Part A: Regulators of Early Invasion of Trophoblast Cells

- Pp. 201-219 (19)
Pankaj Suman and Satish K. Gupta

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Part B: Dendritic Cells: New Insights in Reproduction

- Pp. 220-237 (18)
Sandra M. Blois, Petra C. Arck and Gabriela Barrientos

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Part C: A Summary of Cytokine Networks and Embryo: A Short Overview

- Pp. 238-279 (42)
Gérard Chaouat

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Part D: Human Implantation

- Pp. 280-312 (33)
Nathalie Lédée and Mona Rahmati

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Part E: Interleukin-10: A Vascular and Anti-Inflammatory Cytokine Connecting the Pieces of the Pregnancy Puzzle

- Pp. 313-334 (22)
Satyan Kalkunte, Tania Nevers, Eliana M.O. Lippe and Surendra Sharma

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Part F: Functional Duality of Mouse Uterine Natural Killer Cell in Pregnancy

- Pp. 335-359 (25)
Patricia D. A. Lima, Valdemar A. Paffaro and Aureo T. Yamada

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Part G: Human Uterine Natural Killer Cell: Friends or Foes of Pregnancy Outcomes

- Pp. 360-376 (17)
Eliana M.O. Lippe, Aureo T. Yamada and Surendra Sharma

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Part H: Factors Elevated during Sexual Intercourse Act to Assist Pregnancy Outcome

- Pp. 377-383 (7)
Mukesh K. Jaiswal, Timothy M. Millers, Alice Gilman-Sachs and Kenneth D. Beaman

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Part I: Substances Secreted by the Preimplantation Human Embryo

- Pp. 384-396 (13)
Georgi Georgiev, Jana Pastuschek, Stefan Neubeck and Udo R. Markert

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Part J: Placental Interferons, Implantation and Pregnancy

- Pp. 397-421 (25)
Fuller W. Bazer

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Part K: Pathophysiology of the Complement System at Feto-Maternal Interface

- Pp. 422-434 (13)
Roberta Bulla, Chiara Agostinis and Francesco Tedesco

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Part L: Toll-Like Receptors and Nod-Like Receptors in Gestational Tissues

- Pp. 435-453 (19)
Vikki M. Abrahams

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Tolerance to the Fetal Allograft. Part A: Is the Fetus an Allograft and is it Object of Immunological Tolerance?

- Pp. 454-524 (71)
Gérard Chaouat

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Part B: Immunoregulation at the Interface by Placental Suppressor Factors

- Pp. 525-535 (11)
Gérard Chaouat

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Part C: Immunological Tolerance / Acceptance of the Semi-Allogeneic Embryo: Decidual Transforming Growth Factors and Tolerance Signaling Molecules

- Pp. 536-555 (20)
David A. Clark and Reginald M. Gorczynski

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Part D: Role of Regulatory T Cells in Human Reproduction

- Pp. 556-577 (22)
Leonardo Fainboim

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Part E: The Role of Cytotoxic Natural Killer (NK) Cells and Regulatory NK Cells in Pregnancy

- Pp. 578-591 (14)
Shigeru Saito, Tomoko Shima, Akitoshi Nakashima and Yi Lin

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Part F: Pathways for Activating Implantation Tolerance in Early Pregnancy

- Pp. 592-613 (22)
Sarah A. Robertson, David J. Sharkey, John E. Schjenken, Alison S. Care and Lachlan M. Moldenhauer

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Immuno Endocrine Interactions: An Example; Progestagen Treatment for Threatened and Recurrent Abortion and Molecular Mechanisms

- Pp. 614-624 (11)
Julia Szekeres-Bartho, Melinda Halasz, Beata Polgar and Agnes Bogdan

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The Maternal Inflammatory Response to Pregnancy

- Pp. 625-648 (24)
Jennifer H. Southcombe and Ian L. Sargent

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Are There Abortions of Immunological Origin? Part A: Animal Models of Spontaneous Immunological Abortions

- Pp. 649-675 (27)
Gérard Chaouat

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Part B: Immunology and Recurrent Pregnancy Loss – Epidemiological Aspects in Humans

- Pp. 676-690 (15)
Ole B. Christiansen

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Part C: Immune Treatments: Recent Developments

- Pp. 691-716 (26)
Edward E. Winger and Jane L. Reed

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Part D: Debates on Immunotherapy for Recurrent Pregnancy Failure

- Pp. 717-723 (7)
David A. Clark

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Part E: Debates on Immunotherapy for Recurrent Pregnancy Failure

- Pp. 724-734 (11)
Gérard Chaouat

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Impact of the Immune System on Trophoblast Invasion and Uteroplacental Blood Flow

- Pp. 735-758 (24)
Raj Raghupathy

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Epidemiology and Immunology of Preeclampsia. Part A: Preeclampsia, Plague of Human Reproduction. The Role of Paternity and Immunological Implications

- Pp. 759-785 (27)
Pierre-Yves Robillard and Gustaaf Dekker

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Part B: Animal Models to Find a Cure for Preeclampsia

- Pp. 786-799 (14)

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Autoimmunity in Association with Pregnancy

- Pp. 800-826 (27)
Norbert Gleicher

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The Control of HIV-1 In Utero Transmission at the Materno-Fetal Interface by Immunological Determinants

- Pp. 827-855 (29)
Héloïse Quillay, Romain Marlin, Marion Duriez, Marie-Thérèse Nugeyre and Elisabeth Menu

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Annex 1: Immunology for Assisted Reproductive Practitioners: A Comprehensive Overview

- Pp. 856-883 (28)
Ae-Ra Han, Alice Gilman-Sachs, Joon W. Kim and Joanne Kwak-Kim

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Annex 2: Glossary and Conclusions

- Pp. 884-902 (19)
Gérard Chaouat, Olivier Sandra and Nathalie Lédée
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Index

- Pp. 903-928 (26)
Gérard Chaouat, Olivier Sandra and Nathalie Lédée
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