Editor: Alexander B. Poletaev

Physiologic Autoimmunity and Preventive Medicine

eBook: US $99 Special Offer (PDF + Printed Copy): US $181
Printed Copy: US $131
Library License: US $396
ISBN: 978-1-60805-725-2 (Print)
ISBN: 978-1-60805-724-5 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080572451130101

Introduction

The book is dedicated to the history and current status of physiologic autoimmunity concept and relation between autoimmunity and autoallergy in the context of disease prevention and prediction. The immune system is a natural component, regulator and direct participant in the physiological activities in a healthy body. The main forms of physiological activity of the immune system are based on the intrinsic abilities of self-identification, self-maintenance, self-regulation, and self-reparation — that is recognizing components of the “self ”, i.e. natural autoimmunity. The most ancient and homeostatically important functions of natural autoimmunity are autoclearance as well as construction and support of multicellularity. A considerable number of immune functions, including those related to antimicrobial defense, derive from these basic ones. Various pathological processes in any organ are usually accompanied by different patterns of cell death and, thus, by increased exposure and presentation of self antigens. These events induce the secondary rise in production of autoantibodies with appropriate specificity (opsonines), which provides augmentation of clearance by facilitating the efficacy of macrophage-dependent consumption of debris in the aff ected organ. This phenomenon is sanogenic in nature and adaptive in essence. Therefore, secondary changes in production and serum content of autoantibodies can be considered the universal and earliest detectable marker of any chronic disease. In relation to experimental production and clinical reveal of antibodies towards nuclear antigens, penetrating into living cell nuclei and altering nuclear acid synthesis, cell proliferation and function, autoantibodies can be regarded as hormone-like bioregulators of gene expression. Apparently, immune system is able to reproduce complementary regulators for various cell receptors, including nuclear ones.

Book is unique, it is a single monograph comprehensively including history and current status of natural autoimmunity problem. It describes a fundamental concept essencial for every branch of Medicine and Pathology. The concept described has broad practical application for Health Care, because it establishes effective method of early prediction for many different diseases, creates a basis for prophylaxis. Reader has a chance to get rid of old dogmas and acquire new instrument for fruitful theoretical reasoning, research planning and predictive/preventive practical medical work.

Foreword

- Pp. i-vii (7)
Oleg V. Grinko
Download Free

Preface

- Pp. viii-xi (4)
Alexander B. Poletaev
Download Free

List of Contributors

- Pp. xii-xiii (2)
Alexander B. Poletaev
Download Free

The Main Principles of Adaptive Immune System Function: Self- Recognition, Self-Interaction, and Self-Maintenance

- Pp. 3-20 (18)
Alexander B. Poletaev

PDF Price: $30

View Abstract Purchase Chapter

The Integrative (Co-Operative and Defensive) Function of the Immune System and its Role in Preventive Medicine

- Pp. 21-45 (25)
Zlatko Dembić

PDF Price: $30

View Abstract Purchase Chapter

The Hallmarks of Physiologic Antibody Immunity in Cardiac Diseases and its Impact to Personalized Medicine

- Pp. 46-71 (26)
Olga M. Moiseeva, D.A. Grigoŕeva, Sergey V. Skurydin

PDF Price: $30

View Abstract Purchase Chapter

Autoimmunity vs. Autoallergy in Immunoneuroendocrine Regulation and Dysregulation

- Pp. 72-166 (95)
Leonid P. Churilov, Yury I. Stroev, Albert Sh. Zaichik

PDF Price: $30

View Abstract Purchase Chapter

Autoimmune Phenomena through the View of Predictive, Preventive and Personalized Medicine

- Pp. 167-198 (32)
Anastasiya Putintseva, Sergey Krynskii, Mariya Bocharova, Anna Andreeva, Mathew von Herrath, Dmitrii Kostyshev, Iliya Kurguzov, Paul Muchowski, Artem Kostyakov, Michail Paltsev, Sergey Suchkov

PDF Price: $30

View Abstract Purchase Chapter

Autoantibodies: Serum Content or Profiles?

- Pp. 199-207 (9)
Alexander B. Poletaev

PDF Price: $30

View Abstract Purchase Chapter

Autoimmune Thyroiditis: A New Comorbidity of the Most Prevalent Endocrine Disease, Its Prevention and Prediction

- Pp. 208-233 (26)
Leonid P. Churilov, Yury I. Stroev, Irina Yu. Serdyuk, Oksana M. Mudzhikova

PDF Price: $30

View Abstract Purchase Chapter

Index

- Pp. 234-238 (5)
Alexander B. Poletaev
Download Free

RELATED BOOKS

.The NLRP3 Inflammasome: An Attentive Arbiter of Inflammatory Response.
.Natural Immunomodulators: Promising Therapy for Disease Management.
.Herbal Immunity Boosters Against COVID-19.
.Mitochondrial DNA and the Immuno-inflammatory Response: New Frontiers to Control Specific Microbial Diseases.