Editor: Michel Goldberg

Series Title: Frontiers between Science and Clinic in Odontology

Phosphorylated Extracellular Matrix Proteins of Bone and Dentin

Volume 2

eBook: US $49 Special Offer (PDF + Printed Copy): US $205
Printed Copy: US $181
Library License: US $196
ISSN: 2589-3076 (Print)
ISSN: 2210-2841 (Online)
ISBN: 978-1-60805-562-3 (Print)
ISBN: 978-1-60805-465-7 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080546571120201


Phosphorylated Extracellular Matrix Proteins of Bone and Dentin is the second volume of the e-book series Frontiers between Science and Clinic in Odontology. The phosphorylated proteins of the extracellular matrix of bone and teeth play a crucial structural role in the two tissues. They also act as signaling molecules. Phosphorylated extracellular matrix proteins have been implicated in nucleation and mineralization of skeletal tissues. This e-book covers research on these specific proteins, including details about the cells producing these molecules, their impact on bone and teeth pathology (osteogenesis and dentinogenesis imperfecta) and the potential of these molecules in promoting of inhibiting mineralization.

This e-book also explains processes under the control of some enzymes - TNAP and metalloproteases (MMPs) - such as intracellular regulation in bone and dentine, splicing, respective roles of cleavage products, SIBLINGs, nucleation and crystal growth and regulation.

This second volume serves as a valuable reference to practicing odontologists, biology and biomaterials scientists and tissue engineers interested in protein research related to tooth and bone formation.

Indexed in: Scopus, Book Citation Index, Science Edition, BIOSIS Previews, EBSCO, Ulrich's Periodicals Directory.


- Pp. i-vii (7)
Michel Goldberg
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List of Contributors

- Pp. viii-xiii (6)
Michel Goldberg
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Origin and Evolution of Bone and Dentin and of Acidic Secretory Calcium-Binding Phosphoproteins

- Pp. 3-60 (58)
Jean-Yves Sire, Kazuhiko Kawasaki
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Regulation of Proliferation and Gene Expression in Osteoprogenitor Cells, Osteoblasts and Osteocytes

- Pp. 61-91 (31)
Jeff P. Gorski
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Odontoblasts and Dentin Formation

- Pp. 92-138 (47)
Sasha Dimitrova-Nakov, Yassine Harichane, Anne Baudry, Odile Kellermann, Michel Goldberg
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The Role of SIBLINGs in Human Genetic Diseases

- Pp. 139-156 (18)
Mary MacDougall
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Dentin Sialophosphoprotein (DSPP) Mutations: Implications in Dentinogenesis Imperfecta and Dentin Dysplasia

- Pp. 157-173 (17)
J. Timothy Wright
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Intracellular Mechanisms of Phosphorylation in Osteoblasts and Odontoblasts

- Pp. 174-185 (12)
Thottala Jayaraman, Leslie Bannon, Elia Beniash, Charles Sfeir
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DSPP Gene Transcription and Cellular Signaling Pathways

- Pp. 186-202 (17)
Shuo Chen, Jennifer Schulze McDaniel, Junsheng Feng, Audrey Rakian, Mary MacDougall
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Dentin Sialophosphoprotein (DSPP): Protein Structure & Post- Translational Modifications

- Pp. 203-220 (18)
Yasuo Yamakoshi
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Lessons Learned from Mouse Models of DSPP, DSP, and DPP

- Pp. 221-230 (10)
Shigeki Suzuki, Ashok Kulkarni
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Multifunctional Role of Dentin Matrix Protein 1 in Vertebrate Mineralization

- Pp. 231-250 (20)
Amsaveni Ramachandran, Anne George
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DMP1 In Vivo Function: Studies of Dmp1 Lac Z Knock-in Mice

- Pp. 251-265 (15)
Ling Ye, Yongbo Lu, Chunlin Qin, Jian Q. Feng
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Functional Domains of Bone Sialoprotein

- Pp. 266-282 (17)
Harvey A. Goldberg, Graeme K. Hunter
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Osteopontin: A Plurifunctional Molecule

- Pp. 283-318 (36)
Bernhard Ganss, Anil K. Bansal
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The Multifunctional Roles of MEPE and ASARM-Peptides

- Pp. 319-354 (36)
Peter S.N. Rowe
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Nucleation Mechanisms for Calcium Phosphate Mineralization of Collagenous Matricies

- Pp. 355-379 (25)
Arthur Veis, Stuart R. Stock
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In Vitro and In Vivo Regulation of Mineral Crystal Size and Shape

- Pp. 380-400 (21)
Adele L. Boskey
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Phospholipids: Implication in Bone and Dentin Mineralization

- Pp. 401-421 (21)
Michel Goldberg, Arnaud Marchadier, Anne Negre-Salvayre, Robert Salvayre, Yassine Harichane, Sasha Dimitrova-Nakov, Catherine Vidal, Agnès Kamoun-Goldrat
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Matrix Metalloproteinases in Bone and Dentin

- Pp. 422-437 (16)
Leo Tjäderhane, Marcela R. Carrilho, Lorenzo Breschi
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- Pp. 438-442 (5)
Michel Goldberg
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