Editor: Ichiro Shimizu

Preventive Female Sex Factors against the Development of Chronic Liver Disease

eBook: US $49 Special Offer (PDF + Printed Copy): US $113
Printed Copy: US $89
Library License: US $196
ISBN: 978-1-60805-409-1 (Print)
ISBN: 978-1-60805-293-6 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080529361120101


Liver cancer, cirrhosis and nonalcoholic fatty liver disease are observed predominately in men. Being male or female is believed to be an important human variable that affects health and liver disease throughout the life span. However, few works have been published on the biological mechanisms underlying gender specific differences in liver disease. Several mechanisms underlying sex-associated differences of progression of liver disease are demonstrated in this e-book based on biological factors as estrogen and hepatic iron stores. Readers will gain a better understanding of the pathogenesis of these sex-associated differences in liver disease and on how to design healthcare for liver disease more effectively for individuals belonging to both genders. The e-book should be a useful reference on gender specific medicine for counselors and clinicians as well as for patients with chronic liver disease.

Indexed in: Book Citation Index, Science Edition, Web of Science, Scopus, EBSCO.


- Pp. i-ii (2)
Satoshi Mochida
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- Pp. iii
Ichiro Shimizu
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List of Contributors

- Pp. iv-v (2)
Ichiro Shimizu
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Chronic Liver Diseases Develop More Slowly in Females Than Males

- Pp. 3-18 (16)
Ichiro Shimizu, Tomomi Matsumoto, Nozomi Suzuki, Chiaki Sagara, Yui Koizumi, Tsutoshi Asaki, Yoshiki Katakura, Yosho Fukita
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Gender Difference in Clinicopathologic Features and Prognosis of Patients with Hepatocellular Carcinoma

- Pp. 19-31 (13)
Pisit Tangkijvanich, Kittiyod Poovorawan, Yong Poovorawan
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Body Iron and Chronic Liver Diseases

- Pp. 32-36 (5)
Ichiro Shimizu, Tomomi Matsumoto, Nozomi Suzuki, Chiaki Sagara, Yui Koizumi, Tsutoshi Asaki, Yoshiki Katakura, Yosho Fukita
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HCV Carriers With Normal Alanine Aminotransferase Levels

- Pp. 37-50 (14)
Claudio Puoti
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Innate Immune Response and Sex Hormones

- Pp. 51-60 (10)
Yoshiki Katakura, Tsutoshi Asaki, Yosho Fukita, Ichiro Shimizu
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Role of IL-6 in Gender Differences of Hepatocarcinogenesis

- Pp. 61-69 (9)
Hayato Nakagawa
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Estrogen Reduces Hepatic Fibrosis

- Pp. 70-85 (16)
Tsutoshi Asaki, Tomomi Matsumoto, Nozomi Suzuki, Chiaki Sagara, Yui Koizumi, Yoshiki Katakura, Yosho Fukita, Ichiro Shimizu
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Pharmacological Effects of Estrogen in Liver Cirrhosis-Induced Portal Hypertension

- Pp. 86-93 (8)
Takato Ueno
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Non-Alcoholic Fatty Liver Disease in Females and Males

- Pp. 94-106 (13)
Yosho Fukita, Tsutoshi Asaki, Yoshiki Katakura, Ichiro Shimizu
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Sex and Gender Specific Medicine in Chronic Liver Diseases

- Pp. 107-115 (9)
Sumiko Nagoshi
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- Pp. 116-119 (4)
Ichiro Shimizu
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