Editors: Estela M. Novak, Eduardo M. Rego

Physiopathogenesis of Hematological Cancer

eBook: US $35 Special Offer (PDF + Printed Copy): US $148
Printed Copy: US $131
Library License: US $140
ISBN: 978-1-60805-588-3 (Print)
ISBN: 978-1-60805-259-2 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080525921120101


The number of new discoveries related to diagnostics and therapeutics of hematological cancer is significant. These have resulted in continuous progress in fundamental knowledge about molecular and cellular mechanisms in hematological neoplasia. Physiopathogenesis of Hematological Cancer presents a concise overview of the cellular and molecular biology of myelo- and Lymphoproliferative disorders. The expert reviews presented within this e-book are also accompanied by bibliographic references for relevant scientific literature. This book should prove to be a valuable reference tool for both medical graduate and postgraduates in the field of oncology.


- Pp. i
Roberto Passetto Falcao
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- Pp. ii
Estela Maria Novak, Eduardo Magalhaes Rego
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List of Contributors

- Pp. iii-iv (2)
Estela Maria Novak, Eduardo Magalhaes Rego
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- Pp. v
Estela Maria Novak, Eduardo Magalhaes Rego
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Normal and Leukemic Hematopoietic Cells Niche

- Pp. 3-9 (7)
Eduardo Magalhaes Rego, Mirela de Barros Tamarozzi
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Cancer Stem Cells

- Pp. 10-13 (4)
Sara T. O. Saad
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Programmed Cell Death: Apoptosis, Autophagy, Necrosis and Oxidative Stress in Hematological Malignacies

- Pp. 14-33 (20)
Enny Fernandes Silva
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Proteasome Inhibition in Hematological Malignancies

- Pp. 34-49 (16)
Guilherme Augusto Silva dos Santos
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Epigenetics and DNA Methylation Modifications

- Pp. 50-59 (10)
Fabiola Traina
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microRNAs and Non-Coding RNAs in Hematological Malignancies

- Pp. 60-77 (18)
Hamilton Luiz Gimenes Teixeira, Eduardo Magalhaes Rego
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Transcription Factors in Hematological Malignancies

- Pp. 78-102 (25)
Estela Maria Novak, Durvanei Augusto Maria
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Protein Prenylation and Hematological Malignancies

- Pp. 103-121 (19)
Chin Jia Lin, Mirna Alameddine
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Hematological Neoplasia and Angiogenesis: A Review

- Pp. 122-150 (29)
Estela Maria Novak
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Physiopathogenesis of Lymphoma

- Pp. 151-167 (17)
Edgar Gil Rizzatti
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Molecular Basis of Acute Lymphoblastic Leukemia

- Pp. 168-182 (15)
Carlos Alberto Scrideli, Luiz Gonzaga Tone
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Physiopathogenesis of Multiple Myeloma

- Pp. 183-192 (10)
Luciana Correa Oliveira de Oliveira, Eduardo Magalhaes Rego
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Chronic Myeloproliferative Diseases

- Pp. 193-200 (8)
Katia B. Barbosa Pagnano
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Acute Myeloproliferative Disease

- Pp. 201-217 (17)
Eduardo Magalhaes Rego, Mariana Tereza de Lira Benicio
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Molecular Targeted Therapies for Hematologic Malignancies

- Pp. 218-227 (10)
Alexandre Nonino
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Glossary Terms

- Pp. 228-238 (11)
Estela Maria Novak, Eduardo Magalhaes Rego
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- Pp. 239-243 (5)
Estela Maria Novak, Eduardo Magalhaes Rego
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