Frontiers in Medicinal Chemistry

Volume 5

eBook: US $44 Special Offer (PDF + Printed Copy): US $237
Printed Copy: US $215
Library License: US $176
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)
ISBN: 978-1-60805-675-0 (Print)
ISBN: 978-1-60805-208-0 (Online)
Year of Publication: 2010
DOI: 10.2174/97816080520801100501

Introduction

Frontiers in Medicinal Chemistry is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. “Frontiers in Medicinal Chemistry” covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships.

Medicinal chemistry as a discipline is rapidly maturing. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. “Frontiers in Medicinal Chemistry” aims to contribute in a major way to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. This Ebook series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.

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EMBASE, Scopus, Genamics JournalSeek, EMBiology

Indexed in: Scopus, Book Citation Index, Science Edition, Web of Science, BIOSIS Previews, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Preface

- Pp. i-ii (2)
Allen B. Reitz, Atta-ur-Rahman and M. Iqbal Choudhary
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Contributors

- Pp. vi-ix (2)
Atta-ur-Rahman, Allen B. Reitz and M. Iqbal Choudhary
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Always Around, Never the Same: Pathways of Amyloid Beta Induced Neurodegeneration Throughout the Pathogenic Cascade of Alzheimer

- Pp. 1-14 (14)
Jeroen J.M. Hoozemans, Sidhartha M. Chafekar, Frank Baas, Piet Eikelenboom and Wiep Scheper

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Novel Neuroprotective Therapies for Alzheimer's and Parkinsons's Disease

- Pp. 15-57 (43)
Kirubakaran Shanmugam, Annette E.Maczurek, Megan L.Steele, Obdulio Benavente-García, Julian Castillo and Gerald Munch
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Improving Memory: A Role for Phosphodiesterases

- Pp. 58-80 (23)
Arjan Blokland1, Rudy Schreiber and Jos Prickaerts

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Progress in Current Non-Viral Carriers for Gene Delivery

- Pp. 81-97 (17)
Yoko Shoji-Moskowitz, Daisuke Asai, Ami E.Iskandrian, Kota Kodama, Yoshiki Katayama and Hideki Nakashima

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Protein Transduction: Cell Penetrating Peptides and Their Therapeutic Applications

- Pp. 98-126 (29)
Kylie M. Wagstaff and David A. Jans

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Design of Peptide-Based Vaccines for Cancer

- Pp. 127-166 (40)
Geoffrey A. Pietersz, Dodie S. Pouniotis and Vasso Apostolopoulos
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Inhibitors of Protein: Geranylgeranyl Transferases

- Pp. 167-233 (67)
Farid El Oualid, Gijs A. van der Marel and Mark Overhand

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Voltage-Gated Sodium Channels: New Targets in Cancer Therapy?

- Pp. 234-256 (23)
Ludovic Gillet, Sebastien Roger, Marie Potier, Lucie Brisson, Christophe Vandier, Pierre Besson and Jean-Yves Le Guennec

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Recent Advances in Antiviral Agents: Antiviral Drug Discovery for Hepatitis Viruses

- Pp. 257-271 (15)
Kyuichi Tanikawa

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NO-Releasing Hybrids of Cardiovascular Drugs

- Pp. 272-308 (37)
Alma Martelli, Simona Rapposelli, Maria C. Breschi and Vincenzo Calderone

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Trends in the Development of New Drugs for Treatment of Benign Prostatic Hyperplasia

- Pp. 309-349 (41)
Katarzyna Kulig and Barbara Malawska

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Targeting the Prostaglandin D2 Receptors DP1 and CRTH2 for Treatment of Inflammation

- Pp. 350-380 (31)
Trond Ulven and Evi Kostenis

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Privileged Structures as Leads in Medicinal Chemistry

- Pp. 381-422 (42)
Luca Costantino and Daniela Barlocco

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Acetylcholinesterase Reprised: Molecular Modeling with the Whole Toolkit

- Pp. 423-456 (34)
Gerald H. Lushington, Jian-Xin Guo and Margaret M. Hurley

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