Editors: Atta-ur-Rahman , Allen B. Reitz, M. Iqbal Choudhary

Frontiers in Medicinal Chemistry

Volume 4

eBook: US $44 Special Offer (PDF + Printed Copy): US $441
Printed Copy: US $419
Library License: US $176
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)
ISBN: 978-1-60805-346-9 (Print)
ISBN: 978-1-60805-207-3 (Online)
Year of Publication: 2009
DOI: 10.2174/97816080520731090401

Introduction

“Frontiers in Medicinal Chemistry” is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. “Frontiers in Medicinal Chemistry” covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. Medicinal chemistry as a discipline is rapidly maturing. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. “Frontiers in Medicinal Chemistry” aims to contribute in a major way to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. This Ebook series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.

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Preface

- Pp. iv-v (2)
Allen B. Reitz, M. Iqbal Choudhary and Atta-ur-Rahman
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Contributors

- Pp. ix-xiii (5)
Allen B. Reitz, M. Iqbal Choudhary and Atta-ur-Rahman
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Methods for Ligand-Based Virtual Screening

- Pp. 1-22 (22)
Jurgen Bajorath
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Simple Coumarins: Privileged Scaffolds in Medicinal Chemistry

- Pp. 23-85 (63)
Maria F.M. Borges, Fernanda M.F. Roleira, Nuno J.S.P. Milhazes, Eugenio U. Villare and Lourdes S. Penin

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Chromatography and Computational Chemical Analysis for Drug Discovery

- Pp. 86-129 (44)
Toshihiko Hanai

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New Therapeutic and Experimental Aspects of Chelators as Antidotes of Metal Toxicity

- Pp. 130-182 (53)
Veda M. Varnai, Maja Blanusa, Martina Piasek and Krista Kostial

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Taurine Analogues: A New Class of Therapeutics

- Pp. 183-213 (31)
Ramesh Chandra Gupta, Thida Win and Shmuel Bittner

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Digitalis-Like Compounds: The Discovery of the O-Aminoalkyloxime Group as a Very Powerful Substitute for the Unsaturated γ -Butyrolactone Moiety

- Pp. 214-236 (23)
Mauro Gobbini and Alberto Cerri

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Combinatorial Natural Products: From Cloning to Analysis

- Pp. 237-247 (11)
Paul Budworth, Julia Khandurina and Andras Guttman

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Medicinal Plants for the Prevention and Treatment of Bacterial Infections

- Pp. 248-284 (37)
Gail B. Mahady

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Biologically Active Quassinoids and Their Chemistry: Potential Leads for Drug Design

- Pp. 285-308 (24)
Zhengming Guo, Suryanarayana Vangapandu, Robert W. Sindelar, Larry A. Walker and Robert D. Sindelar

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Medicinal Plant Extracts and Molecules as the Source of New Anti-Snake Venom Drugs

- Pp. 309-346 (38)
Andreimar M. Soares, Silvana Marcussi, Renata S. Fernandes, Danilo L. Menaldo, Tassia R. Costa, Miriam V. Lourenco, Ana Helena Januario and Paulo S. Pereira

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Recent Advances in the Development of Selective Small Molecule Inhibitors for Cyclin-Dependent Kinases

- Pp. 347-370 (24)
Hiroshi Hirai, Nobuhiko Kawanishi and Yoshikazu Iwasawa

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Protein Tyrosine Phosphatases and Their Inhibitors

- Pp. 371-423 (53)
Yogesh S. Tingare, Purushottam M. Dewang, Nai-Mu Hsu, Shao-Zheng Peng and Wen-Ren Li

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Matrix Metalloproteinase Inhibitors: A Review on Pharmacophore Mapping and (Q)SARs Results

- Pp. 424-462 (39)
Christos A. Kontogiorgis, Paraskevi Papaioannou and Dimitra J. Hadjipavlou-Litina

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Drug Delivery Strategies for the Treatment of Helicobacter pylori Infections

- Pp. 463-490 (28)
Barbara R. Conway

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Anti-HIV Activities of Natural Antioxidant Caffeic Acid Derivatives: Toward an Antiviral Supplementation Diet

- Pp. 491-505 (15)
Fabrice Bailly and Philippe Cotelle

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Recent Advances in New Structural Classes of Anti-Tuberculosis Agents

- Pp. 506-540 (35)
Amit Nayyar, Sanjay R. Patel and Rahul Jain

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Applications for Peptide-Based Cancer Vaccine Design

- Pp. 541-561 (21)
Eliada Lazoura, Stephanie L. Day and Vasso Apostolopoulos

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Telomerase Inhibition and Cancer: Might Platinum Based Drugs Have a Future as Anti-Telomerase Pharmacological Approach?

- Pp. 562-586 (25)
Donato Colangelo and Domenico Osella

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Recent Developments in the Field of Non Peptidic α vβ 3 Antagonists

- Pp. 587-618 (32)
Barbara Cacciari, Pamela Crepaldi, Stephanie Federico and Giampiero Spalluto

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Non-Hydroxamate Histone Deacetylase Inhibitors

- Pp. 619-641 (23)
Takayoshi Suzuki and Naoki Miyata

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New Lipid-Lowering Agents Acting on LDL Receptors

- Pp. 642-660 (19)
Hubert Scharnagl, Tatjana Stojakovic and Winfried Marz

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Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes

- Pp. 661-687 (27)
John W. Huffman and Lea W. Padgett

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Novel Therapies for Asthma - Advances and Problem

- Pp. 688-706 (19)
Garry M. Walsh

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Drugs to Treat Inflammation: A Historical Overview

- Pp. 707-729 (23)
Michael Whitehouse

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Drug Development and Diagnostics for Alzheimer's Disease Up to 2008

- Pp. 730-766 (37)
Nicole Hottecke, Stefanie Baumann, Ali Taghavi, Hannes A. Braun and Boris Schmidt

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Therapeutic Opportunities in Alzheimer Disease: Current Concepts

- Pp. 767-788 (22)
Michael W. Marlatt, Paula I. Moreira, Hyoung-Gon Lee, Gemma Casadesus, Rudy J. Castellani, Atsushi Takeda, Akihiko Nunomura, Xiongwei Zhu, George Perry and Mark A. Smith

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N-Hydroxyurea and Acyl Nitroso Compounds as Nitroxyl (HNO) and Nitric Oxide (NO) Donors

- Pp. 789-804 (16)
S. Bruce King

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New Anticonvulsant Agents

- Pp. 805-841 (37)
Barbara Malawska

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Selective Neuronal Nitric Oxide Synthase Inhibitors

- Pp. 842-882 (41)
Haitao Ji, Erik P. Erdal, Elizabeth A. Litzinger, Jiwon Seo, Yaoqiu Zhu, Fengtian Xue, Jianguo Fang, Jinwen Huang and Richard B. Silverman
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