Frontiers in Medicinal Chemistry

Volume 3

eBook: US $44 Special Offer (PDF + Printed Copy): US $391
Printed Copy: US $369
Library License: US $176
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)
ISBN: 978-1-60805-674-3 (Print)
ISBN: 978-1-60805-206-6 (Online)
Year of Publication: 2006
DOI: 10.2174/97816080520661060301

Introduction

Frontiers in Medicinal Chemistry is a book series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. Frontiers in Medicinal Chemistry covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships.

Medicinal chemistry as a discipline is rapidly maturing. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Frontiers in Medicinal Chemistry aims to contribute in a major way to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. This book series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.

Indexed in: Scopus, EMBASE, Scilit, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Editorial

- Pp. iv- (1)
Allen B. Reitz, Cheryl P. Kordik, Atta ur-Rahman, M. Iqbal Chouhary
Download Free

Contributors

- Pp. ix-xiv (6)
Atta ur-Rahman, Allen B. Reitz
Download Free

Structure and Function of HIV-1 Integrase: An Update

- Pp. 3-22 (20)
Thang K. Chiu, David R. Davies

PDF Price: $15

View Abstract Purchase Chapter

Anti-HIV Drugs and Resistance: Inhibitors of HIV-1 Reverse Transcriptase and Protease

- Pp. 23-44 (22)
Tomozumi Imamichi

PDF Price: $15

View Abstract Purchase Chapter

Gene Therapy for Cardiovascular Diseases

- Pp. 59-85 (27)
Marcin Gruchala, Himadri Roy, Shalini Bhardwaj, Seppo Yla-Herttuala

PDF Price: $15

View Abstract Purchase Chapter

Drug Development and the Importance of Ethnicity: Lessons from Heart Failure Management and Implications for Hypertension

- Pp. 45-58 (14)
Michael D. Sosin, Gurbir S. Bhatia, Gregory Y.H. Lip, Russell C. Davis

PDF Price: $15

View Abstract Purchase Chapter

Design and Discovery of Novel Antihypertensive Drugs Through Conformation and Bioactivity Studies

- Pp. 87-111 (25)
Thomas M. Mavromoustakos, Maria V. Zervou, Panagiotis G. Zoumpoulakis

PDF Price: $15

View Abstract Purchase Chapter

Novel Antiarrhythmic Compounds with Combined Class IB and Class III Mode of Action

- Pp. 113-124 (12)
Peter Matyus, Ildiko Varga, Tivadar Rettegi, Antal Simay, Peter Kovacs, Laszlo Karolyhazy, Akos Kocsis, Szilvia Vajda, Andras Varro, Istvan Penzes, Julius Gy. Papp

PDF Price: $15

View Abstract Purchase Chapter

A1 Adenosine Receptor Agonists: Medicinal Chemistry and Therapeutic Potential

- Pp. 125-151 (27)
Sally A. Hutchinson, Peter J. Scammells

PDF Price: $15

View Abstract Purchase Chapter

Are the Extracellular Pathways a Conduit for the Delivery of Therapeutics to the Brain?

- Pp. 153-161 (9)
William A. Banks
View Abstract

A Review of Neuroprotective Agents

- Pp. 163-194 (32)
Margaret A. Brimble, Mark S. Levi

PDF Price: $15

View Abstract Purchase Chapter

Design of Ligands for the Nicotinic Acetylcholine Receptors: The Quest for Selectivity

- Pp. 195-247 (53)
William H. Bunnelle, Michael J. Dart, Michael R. Schrimpf

PDF Price: $15

View Abstract Purchase Chapter

New Trends in the Design of Drugs Against Alzheimer's Disease

- Pp. 249-284 (36)
Pierre Francotte, Pascal de Tullio, Pierre Fraikin, Bernard Pirotte

PDF Price: $15

View Abstract Purchase Chapter

Development of Melanocortin Receptor Selective Ligands

- Pp. 285-334 (50)
Boman G. Irani, Jerry R. Holder, Aleksandar Todorovic, Andrzej M. Wilczynski, Christine G. Joseph, Krista R. Wilson, Carrie Haskell-Luevano

PDF Price: $15

View Abstract Purchase Chapter

Inhibition of Protein Tyrosine Phosphatase 1B for the Treatment of Diabetes and Obesity

- Pp. 335-368 (34)
Zhonghua Pei, Gang Liu, Thomas H. Lubben, Bruce G. Szczepankiewicz

PDF Price: $15

View Abstract Purchase Chapter

The Impact of Infection on the Incidence of Autoimmune Disease

- Pp. 369-382 (14)
Thomas D.C. Thomas, Paola Zaccone, David W. Dunne, Anne Cooke

PDF Price: $15

View Abstract Purchase Chapter

Transcription Factors in Autoimmune Diseases

- Pp. 383-397 (15)
Martin Eggert, Andreas Kluter, Uwe K. Zettl, Gunther Neeck

PDF Price: $15

View Abstract Purchase Chapter

Small Molecule FLT3 Tyrosine Kinase Inhibitors

- Pp. 399-416 (18)
Mark Levis, Donald Small

PDF Price: $15

View Abstract Purchase Chapter

Potentiality and Limitations of a Strategy for the Control of Cell Proliferation: The Block of Ca2+ Entry

- Pp. 417-433 (17)
Luca Munaron, Susanna Antoniotti, Alessandra Fiorio Pla, Davide Lovisolo

PDF Price: $15

View Abstract Purchase Chapter

An Expanding Appreciation of the Role Chemokine Receptors Play in Cancer Progression

- Pp. 435-454 (20)
O. M. Zack Howard, Carole L. Galligan

PDF Price: $15

View Abstract Purchase Chapter

Structural Bioinformatics and its Impact to Biomedical Science and Drug Discovery

- Pp. 455-502 (48)
Kuo-Chen Chou

PDF Price: $15

View Abstract Purchase Chapter

Recent Advances in Chemical Genomics

- Pp. 503-550 (48)
Gyorgy Dorman, Peter Krajcsi, Laszlo G. Puskas, Zoltan Kovari, Zsolt Lorincz, Laszlo Urge, Ferenc Darvas

PDF Price: $15

View Abstract Purchase Chapter

Predicting Molecular Interactions In Silico: I. An Updated Guide to Pharmacophore Identification and its Applications to Drug Design

- Pp. 551-584 (34)
Oranit Dror, Alexandra Shulman-Peleg, Ruth Nussinov, Haim J. Wolfson
View Abstract

In Silico Methods for Predicting Ligand Binding Determinants of Cytochromes P450

- Pp. 615-652 (38)
Marcel J. de Groot, Stewart B. Kirton, Michael J. Sutcliffe

PDF Price: $15

View Abstract Purchase Chapter

Trends in Hit-to-Lead: An Update

- Pp. 653-673 (21)
Benoit Deprez, Rebecca Deprez-Poulain

PDF Price: $15

View Abstract Purchase Chapter

Recent Development and Application of Virtual Screening in Drug Discovery: An Overview

- Pp. 675-703 (29)
Tingjun Hou, Xiaojie Xu

PDF Price: $15

View Abstract Purchase Chapter

Biology of Heme in Health and Disease

- Pp. 705-714 (10)
Nastiti Wijayanti, Stephan Immenschuh

PDF Price: $15

View Abstract Purchase Chapter

RELATED BOOKS

.Herbs for Disease Prevention and Treatment.
.Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules.
.The Chemistry Inside Spices and Herbs: Research and Development.
.The Chemistry Inside Spices & Herbs: Research and Development.