Frontiers in Medicinal Chemistry

Volume 2

eBook: US $44 Special Offer (PDF + Printed Copy): US $309
Printed Copy: US $287
Library License: US $176
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)
ISBN: 978-1-60805-673-6 (Print)
ISBN: 978-1-60805-205-9 (Online)
Year of Publication: 2005
DOI: 10.2174/97816080520591050201

Introduction

Frontiers in Medicinal Chemistry is a book series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. Frontiers in Medicinal Chemistry covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships.

Medicinal chemistry as a discipline is rapidly maturing. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Frontiers in Medicinal Chemistry aims to contribute in a major way to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. This book series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.

Indexed in: Scopus, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Editorial

- Pp. iv- (1)
Allen B. Reitz, Atta-ur-Rahman, Cheryl P. Kordik and M. Iqbal Choudhary
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Contributors

- Pp. viii-xiii (6)
Allen B. Reitz, Atta-ur-Rahman, Cheryl P. Kordik and M. Iqbal Choudhary
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Novel Inhibitors of HIV Integrase: The Discovery of Potential Anti-HIV Therapeutic Agents

- Pp. 3-20 (18)
Vasu Nair

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Macrolide Antibiotics: Binding Site, Mechanism of Action, Resistance

- Pp. 21-35 (15)
Marne Gaynor and Alexander S. Mankin

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Potential New Targets for Antithrombotic Therapy

- Pp. 37-48 (12)
Andras Gruber and Stephen R. Hanson
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Potent and Selective A2A Adenosine Receptor Antagonists: Recent Improvement

- Pp. 49-62 (14)
Barbara Cacciari, Giorgia Pastorin, Stefano Moro and Giampiero Spalluto

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Updating the Dual Role of Brain Nitric Oxide in Neurodegeneration/Neuroprotection: Understanding Molecular Mechanisms to Devise Drug Approaches

- Pp. 63-109 (47)
Antonio Contestabile, Barbara Monti, Andrea Contestabile and Elisabetta Ciani

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Effect of Genetic Background on Ionotropic Glutamate Receptor and Neurotrophin Biology: Synaptic Connectivity and Function in Neurological Disease

- Pp. 111-132 (22)
Gregory N. Barnes and John T. Slevin

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Medical Marijuana in CNS Disorders

- Pp. 133-159 (27)
Alison J. Drysdale and Bettina Platt

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Obesity and Diabetes Gene Discovery Approaches

- Pp. 161-182 (22)
Ken Walder, David Segal, Jeremy Jowett, John Blangero and Greg R. Collier
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Understanding the Molecular Mechanism of Action of Estrogen Receptor Modulators

- Pp. 183-231 (49)
Mary J. Meegan and David G. Lloyd

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Recent Advances in Peroxisome Proliferator- Activated Receptor Science

- Pp. 233-251 (19)
Barry G. Shearer and William J. Hoekstra

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Recent Developments in the Synthesis and Evaluation of Glucose Analog Inhibitors of Glycogen Phosphorylases as Potential Antidiabetic Agents

- Pp. 253-272 (20)
Laszlo Somsak, Veronika Nagy, Zsuzsa Hadady, Nora Felfoldi, Tibor Docsa and Pal Gergely

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Regulation by Nicotine of Food Intake and Body Weight: Implications for Obesity Treatment

- Pp. 273-297 (25)
Ming D. Li, Justin K. Kane and Ozlen Konu

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Histone Deacetylase Inhibitors: From Chromatin Remodelling to Experimental Cancer Therapeutics

- Pp. 299-315 (17)
Janine Arts, Stefanie de Schepper and Kristof Van Emelen

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Radiogenetic Therapy Using Radiation-Responsive Gene Promoters

- Pp. 317-330 (14)
Brian Marples, Olga Greco, Michael C. Joiner and Simon D. Scott

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Inhibitors of Farnesyltransferase and Geranylgeranyltransferase-I for Antitumor Therapy: Substrate-Based Design, Conformational Constraint and Biological Activity

- Pp. 331-355 (25)
Christopher J. Dinsmore and Ian M. Bell

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Enediyne Natural Products: Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents

- Pp. 357-369 (13)
Ben Shen, Wen Liu and Koichi Nonaka

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Heparin Derivatives and Semisynthetic Biotechnological Heparins as Angiogenesis Inhibitors

- Pp. 371-391 (21)
Marco Presta, Daria Leali, Helena Stabile, Roberto Ronca, Maura Camozzi, Emanuela Moroni, Stefania Nicoli, Sandra Liekens and Marco

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VIP and Drug Design 2004

- Pp. 393-415 (23)
Illana Gozes and Sharon Furman

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Chemical Genomics-Based Target Mining and Validation of Biologically Active Small Molecules

- Pp. 417-430 (14)
Ho Jeong Kwon

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Ethnobotany and Natural Products: The Search for New Molecules, New Treatments of Old Diseases or a Better Understanding of Indigenous Cultures?

- Pp. 431-450 (20)
Michael Heinrich

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Natural Killer T Cells as Targets for Therapeutic Intervention in Autoimmune Diseases

- Pp. 451-484 (34)
Michael T. Wilson and Luc Van Kaer

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Combinatorial Synthesis of Small Molecule Libraries by Microwave Technology

- Pp. 485-510 (26)
Chung-Ming Sun

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Pharmacophore Discovery - Lessons Learned

- Pp. 511-532 (22)
John H. van Drie

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Drug Discovery Today

- Pp. 533-543 (11)
Oliver Schwardt, Brian Cutting, Hartmuth Kolb and Beat Ernst

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Theoretical Property Predictions

- Pp. 545-570 (26)
David J. Livingston

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Prediction of Drug Metabolism: The Case of Cytochrome P450 2D6

- Pp. 571-586 (16)
Nico P.E. Vermeulen

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Subject Index to Volume 2

- Pp. 587-606 (20)
Bentham Science Publishers
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