Frontiers in Medicinal Chemistry

Volume 1

eBook: US $44 Special Offer (PDF + Printed Copy): US $345
Printed Copy: US $323
Library License: US $176
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)
ISBN: 978-1-60805-672-9 (Print)
ISBN: 978-1-60805-204-2 (Online)
Year of Publication: 2004
DOI: 10.2174/97816080520421040101

Introduction

Frontiers in Medicinal Chemistry is a book series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. Frontiers in Medicinal Chemistry covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships.

Medicinal chemistry as a discipline is rapidly maturing. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Frontiers in Medicinal Chemistry aims to contribute in a major way to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. This book series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.

Indexed in: Scopus, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Preface

- Pp. i
Atta-ur-Rahman, M. Iqbal Choudhary, Allen B. Reitz and Cheryl P. Kordik
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Targeting Protein Kinases for Bone Disease: Discovery and Development of Src Inhibitors

- Pp. 3-27 (25)
Chester A. Metcalf, Marie Rose van Schravendijk, David C. Dalgarno and Tomi K. Sawyer
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Inhibitors of Matrix Metalloproteinases: Design, Structure and Therapeutic Applications

- Pp. 29-75 (47)
Jerry W. Skiles, Nina C. Gonnella and Arco Y. Jeng
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Mechanism-based Inhibition of Metalloproteinases

- Pp. 77-83 (7)
Dong H. Kim and Shahriar Mobashery

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Selective COX-2 Inhibitors and Dual Acting Anti-inflammatory Drugs: Critical Remarks

- Pp. 85-95 (11)
A. Bertolini, A. Ottani and M. Sandrini

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Protein Farnesyltransferase Inhibitors

- Pp. 97-128 (32)
Semiramis Ayral-Kaloustian and Edward J. Salaski

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The Design of Competitive, Small-molecule Inhibitors of Coagulation Factor Xa

- Pp. 129-152 (24)
Henry W. Pauls, William R. Ewing and Yong Mi Choi-Sledeski

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Small Molecule Activators of the Insulin Receptor: Potential New Therapeutic Agents for the Treatment of Diabetes Mellitus

- Pp. 153-164 (12)
Edgardo Laborde and Vara Prasad Manchem

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Current Therapies and Emerging Targets for the Treatment of Diabetes

- Pp. 165-187 (23)
Allan S. Wagman and John M. Nuss

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Designed Enediyne Antitumor Agents

- Pp. 189-214 (26)
G.B. Jones and F.S. Fouad

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Combinatorial Approaches in Anticancer Drug Discovery: Recent Advances in Design and Synthesis

- Pp. 215-235 (21)
Sukanta Bhattacharyya

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The Expanding Role of NMR in Rational Drug Design

- Pp. 237-271 (35)
Rickey P. Hicks and Daniel A. Nichols

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Mass Spectrometry Based Assays for Drug Screening in the Early Phases of Drug Discovery

- Pp. 273-292 (20)
Marshall M. Siegel

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Recent Advances in PDE4 Inhibitors as Immunoregulators and Antiinflammatory Drugs

- Pp. 293-345 (53)
Catherine Burnouf, Ingrid Devillers and Marie-Pierre Pruniaux

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Serotonin Reuptake Inhibition: An Update on Current Research Strategies

- Pp. 347-359 (13)
D. Spinks and G. Spinks

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Emerging β-Amyloid Therapies for the Treatment of Alzheimer's Disease

- Pp. 361-384 (24)
Kelly A. Conway, Ellen W. Baxter, Kevin M. Felsenstein and Allen B. Reitz

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Oxidative Stress in Animal Models of Accelerated Aging, Alzheimer’s Disease and Huntington’s Disease

- Pp. 385-397 (13)
D. Allan Butterfield

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Constitutive Activity of Brain Serotonin Receptors: Inverse Agonist Activity of Antipsychotic Drugs

- Pp. 399-408 (10)
Anil Purohit, Katharine Herrick-Davis and Milt Teitler

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Physicochemical Profiling (Solubility, Permeability and Charge State)

- Pp. 409-475 (67)
Alex Avdeef

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Non-peptide Opioid Receptor Ligands - Recent Advances. Part I - Agonists

- Pp. 477-500 (24)
Agnieszka Kaczor and Dariusz Matosiuk

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Nitric Oxide Therapies in Vascular Diseases

- Pp. 501-512 (12)
E.M. Kurowska

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Strategies to Improve Stability and Bioavailability of Peptide Drugs

- Pp. 513-528 (16)
Céline Adessi and Claudio Soto

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The Role of Genomics in the Discovery of Novel Antibacterial Targets

- Pp. 529-542 (14)
Jerry M. Buysse

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New Anti-HIV Agents in Preclinical or Clinical Development

- Pp. 543-579 (37)
Erik De Clercq

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DNA Minor Groove Alkylators

- Pp. 581-594 (14)
William A. Denny

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Applications of Small Molecule Crystallography and the Cambridge Structural Database in Drug Design

- Pp. 595-606 (12)
Johan Wouters and Frédéric Ooms

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Compound Optimization in Early and Late Phase Drug Discovery: Acceptable Pharmacokinetic Properties Utilizing Combined Physicochemical, In Vitro and In Vivo Screens

- Pp. 607-618 (12)
Gary W. Caldwell

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DNA-binding of Drugs Used in Medicinal Therapies

- Pp. 619-645 (27)
G. Bischoff, S. Hoffmann and R. Zhdanov

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The Contribution of Combinatorial Chemistry to Lead Generation: An Interim Analysis

- Pp. 647-662 (16)
Anton E.P. Adang and Pedro H.H. Hermkens

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New Paradigms in Drug Design and Discovery

- Pp. 663-681 (19)
Joseph J. Barchi and Nouri Neamati

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Author Index

- Pp. 683
Atta-ur-Rahman and Allen B. Reitz
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Subject Index

- Pp. 685-688 (4)
Atta-ur-Rahman and Allen B. Reitz
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