Frontiers in Drug Design and Discovery

Volume 3

eBook: US $44 Special Offer (PDF + Printed Copy): US $321
Printed Copy: US $299
Library License: US $176
ISSN: 1574-0889 (Print)
ISSN: 2212-1064 (Online)
ISBN: 978-1-60805-671-2 (Print)
ISBN: 978-1-60805-201-1 (Online)
Year of Publication: 2007
DOI: 10.2174/97816080520111070301

Introduction

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The book series should prove to be of interest to all the pharmaceutical scientists involved in research in drug design and discovery. Each volume is devoted to the major advances in drug design and discovery.

The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

The book series is available in print, online and CD editions.

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EMBASE, Scopus, Genamics JournalSeek

Indexed in: Scopus, EMBASE, EBSCO, Ulrich's Periodicals Directory.

Editorial: Structure-Based Drug Design in the 21st Century

- Pp. i-iii (3)
Atta-ur-Rahman, M. Iqbal Choudhary, Gary W. Caldwell and Mark R. Player
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Alpha-Helix Mimetics: Progress Toward Effective Modulation of Protein-Protein Complexes

- Pp. 5-44 (40)
Daniel J. Parks and Mark R. Player

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Structures of HIV Protease Guide Inhibitor Design to Overcome Drug Resistance

- Pp. 45-62 (18)
Irene T. Weber, Andrey Y. Kovalevsky and Robert W. Harrison

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Structure and Function of G Protein-Coupled Receptors Studied Using Sequence Analysis, Molecular Modeling and Receptor Engineeri

- Pp. 63-79 (17)
Stefano Costanzi, Andrei A. Ivanov, Irina G. Tikhonova and Kenneth A. Jacobson
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Virtual Docking: How Are We Doing And How Can We Improve?

- Pp. 81-103 (23)
Renee L. DesJarlais, Maxwell D. Cummings and Alan C. Gibbs

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Fragment-Based Lead Discovery by NMR

- Pp. 105-119 (15)
Markus Schade

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Targeting Drug Resistant Mutations Using Novel Binding Interactions - Lessons Learned from Abl-T315I and their Implications in D

- Pp. 121-144 (24)
Glen Noronha, Jianguo Cao, Chun Chow, Elena Dneprovskaia, Linda Hwang, Dan Lohse, Chi Ching Mak, Andrew McPherson, Richard M. Fine, Xinshan Kang, Boris Klebansky, Moorthy S.S. Palanki, Ved P. Pathak, Joel Renick, Richard Soll and Binqi Zeng

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Recent Advances in the Structure-Guided Design of Protein Kinase Inhibitors

- Pp. 145-170 (26)
Campbell McInnes
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Fragment-Based Approaches to Lead Discovery

- Pp. 171-202 (32)
Daniel F. Wyss and Hugh L. Eaton

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Recent Advances in Structure-Based Design of Nuclear Hormone Receptors

- Pp. 203-224 (22)
Ronald L. Magolda, William S. Somers and Rayomand J. Unwalla

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Structure-Based Drug Development Against Malaria

- Pp. 225-255 (31)
Kathrin Buchholz, Boniface Mwongela Mailu, R. Heiner Schirmer and Katja Becker

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Virtual Screening of Compound Libraries Using In silico Three Dimensional Pharmacophores to Aid the Discovery and Design of Anti

- Pp. 257-292 (36)
Apurba K. Bhattacharjee

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DNA Helicases Implicated in Chromosomal Instability Disorders as Targets for the Discovery of Novel Anti-Cancer Agents

- Pp. 293-316 (24)
Rigu Gupta and Robert M. Brosh

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Scoring Functions for Virtual Screening

- Pp. 317-379 (63)
Francesca Spyrakis, Glen E. Kellogg, Alessio Amadasi and Pietro Cozzini

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Reactivators of Tabun-Inhibited Acetylcholinesterase: Structure-Biological Activity Relationship

- Pp. 381-394 (14)
Kamil Kuca, Daniel Jun, Kamil Musilek and Jiri Bajgar

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Peptide Diversity in Drug Discovery

- Pp. 395-432 (38)
Marian P. Brennan, Dermot Cox and Anthony J. Chubb

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Protection of Neurovascular Injury by Vasoprotective Agents: A Novel Therapeutic Strategy for Ischemic Brain Edema

- Pp. 433-454 (22)
Feng Han, Norifumi Shioda, Yasufumi Shirasaki and Kohji Fukunaga

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Protein Flexibility and Mobility in Structure-Based Drug Design

- Pp. 455-476 (22)
Aqeel Ahmed, Sina Kazemi and Holger Gohlke

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Structure-Based Virtual Screening

- Pp. 477-502 (26)
György M. Keseru

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Computer-Aided Engineering of GPCRS and Its Application to Drug Discovery

- Pp. 503-523 (21)
Antonio Lavecchia

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Antibody-Drug Conjugates in Targeted Therapy for Cancer

- Pp. 525-537 (13)
Ruoping Tang, Simy Cohen, Ollivier Legrand and Jean-Pierre Marie

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Structure-Activity Relationships in Peptides: from Modelling to Rational Drug Design

- Pp. 539-558 (20)
Ettore Benedetti, Carlo Pedone and Michele Saviano

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Rational Design Strategies for the Development of Synthetic Quinoline and Acridine Based Antimalarials

- Pp. 559-609 (51)
Michael J. Dascombe, Michael G.B. Drew, Philip G. Evans and Fyaz M.D. Ismail

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Contributors

- Pp. 611-617 (7)
Atta-ur-Rahman, Gary W. Caldwell, M. Iqbal Choudhary and Mark R. Player
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Subject Index to Volume 3

- Pp. 619-634 (16)
Atta-ur-Rahman, Gary W. Caldwell, M. Iqbal Choudhary and Mark R. Player
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