Chapter 12

Biocatalysis in Organic Synthesis

Robert Azerad


Biocatalytic reactions using enzymes or whole microbial cells are increasingly employed for organic synthesis, taking advantage of their high versatility and exquisite selectivities (chemo-, regio- and stereoselectivity). Resolution of racemates and its refinements, desymmetrisation of meso- and prochiral compounds by oxidoreduction, some C-C bond forming reactions and other miscellaneous reactions will be outlined, illustrating the most characteristic aspects of environmentally friendly and yield-effective production of commodity chemicals, stereospecific building blocks or intermediates, and competitive step-replacement strategies for asymmetric syntheses.

Total Pages: 455-518 (64)

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.Exercises in Organic Synthesis Based on Synthetic Drugs.
.Advances in Organic Synthesis.
.Advances in Organic Synthesis.
.Perhalopyridines: Synthesis and Synthetic Utility.