Editors: Atta-ur-Rahman, M.Iqbal Choudhary

Anti-Obesity Drug Discovery and Development

Volume 1

eBook: US $44 Special Offer (PDF + Printed Copy): US $155
Printed Copy: US $133
Library License: US $176
ISSN: 2467-9615 (Print)
ISSN: 2210-2698 (Online)
ISBN: 978-1-60805-584-5 (Print)
ISBN: 978-1-60805-163-2 (Online)
Year of Publication: 2011
DOI: 10.2174/97816080516321110101

Introduction

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs.

Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. Fifteen well written reviews make this special volume an excellent compilation of recent developments in anti-obesity treatment. The reviews cover a variety of topics including the development of specific, safe and effective receptor antagonists, the role of epithelial endocrine cells and post operative treatment strategies. This book should be useful to clinicians and medicinal chemists involved in ant-obesity research and therapy.

Indexed in: Scopus, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Preface

- Pp. i-ii (2)
Atta-ur-Rahman, M. Iqbal Choudhary
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Contributors

- Pp. iii-vi (4)
Atta-ur-Rahman, M. Iqbal Choudhary
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Prevalence of Obesity: The Global Epidemics

- Pp. 1-20 (20)
Ya-Wen Hsu, Po-Wen Ku, Da-Chen Chu, Tsan-Hon Liou, Pesus Chou
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HDL Levels in Obesity

- Pp. 21-48 (28)
Justina Costandi, Michelle Melone, Shirya Rashid
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Inflammatory and Metabolic Markers in Pre- and Post- Treatment of Obesity

- Pp. 49-66 (18)
Silvia de Barros-Mazon, Daniela Miguel Marin, Camila Puzzi de Carvalho, Sarah Monte Alegre
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Pharmacological Approach for Obesity

- Pp. 67-81 (15)
Mohannad Kusti, Forrest Olgers, Ehab Akkary
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Omics Approaches to Obesity and Complex Disorders: Challenges and New Opportunities

- Pp. 82-95 (14)
Kyoungmi Kim, Stanislav O. Zakharkin
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The Search for New Anti-Obesity Agents to Reduce Cardiometabolic Risk

- Pp. 96-113 (18)
Cynthia Arbeeny
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Monoaminergic Systems and Anti-Obesity Drug Discovery: Chronic Administration of Sympathicomimetic Amines, Re- Uptake Inhibitors, or Amine Oxidase Inhibitors?

- Pp. 114-130 (17)
Christian Carpene, Zsuzsa Iffiu-Soltesz
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Rimonabant for Obesity

- Pp. 131-149 (19)
Cintia Curioni, Cintia Azara, Jane Capelli
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Phytochemicals as Potential Agents for Prevention and Treatment of Obesity and Metabolic Diseases

- Pp. 150-185 (36)
Taesun Park, Yunjung Kim
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Targeting the Opioid System: An Effective Treatment for Obesity?

- Pp. 186-199 (14)
Caroline Reid, Caroline Davis
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Development of Melanin Concentrating Hormone Receptor R1 Antagonists for the Pharmacological Treatment of Obesity

- Pp. 200-228 (29)
Gildardo Rivera, Antonio Monge, Virgilio Bocanegra-Garcia
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CBR1 Blockade and New Anti-Obesity Drugs Development: Targeting the Adipose Tissue

- Pp. 229-236 (8)
Laurence Hoareau, Karima Bencharif, Regis Roche
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Gastric Endocrine Cell and Food Intake Regulation

- Pp. 237-250 (14)
Andreas Stengel, Miriam Goebel, Yvette Tache
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Mitigation Strategies of Obesity-Induced Inflammation and Metabolic Syndrome

- Pp. 251-264 (14)
Andreas D. Flouris, Andres E. Carrillo, Giorgos S. Metsios
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Medication Absorption Post-Bariatric Surgery with Emphasis on Management of Vitamin Deficiencies

- Pp. 265-282 (18)
Susan Jacob, Nhu Nguyen, Christian S. Jackson, Stewart Rendon
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Author Index

- Pp. 283
Atta-ur-Rahman, M. Iqbal Choudhary
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