Author: Robert E. Smith

Medicinal Chemistry - Fusion of Traditional and Western Medicine, First Edition

eBook: US $89 Special Offer (PDF + Printed Copy): US $298
Printed Copy: US $254
Library License: US $356
ISBN: 978-1-60805-154-0 (Print)
ISBN: 978-1-60805-149-6 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080514961130101

Introduction

Medicinal Chemistry - Fusion of Traditional and Western Medicine is a textbook intended for students taking courses in the various fields of medicinal chemistry, pharmacy, medical and dental programs. Moreover, people working in the pharmaceutical industry and doctors preparing for Medical Board Exams will also find it useful. Since, new drugs are being developed by multi-disciplinary teams; this E-Book describes new paradigms that are emerging in modern biology, biochemistry and medicine. It is therefore a fusion of traditional and western medicine and between systems thinking and reductionist thinking. Readers will learn about how new drugs are investigated, developed and eventually approved by the FDA. The book also includes important information about cGMP, GLP and the FDA regulatory requirements, the importance of environmental toxins, such as bisphenol A (BPA) and perfluorooctanoic acid (PFOAA) in autoimmune diseases and health. This book offers exceptional value in its descriptions of RNA, epigenetics, toxicology, new drug development, genetically modified organisms and analytical chemistry that cannot be found in other textbooks.

Indexed in: Book Citation Index, Science Edition, Scopus, EBSCO.

Foreword

- Pp. i-ii (2)
Mark D. Pilley
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Preface

- Pp. iii-iv (2)
Robert E. Smith
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Introduction

- Pp. 3-86 (84)
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How New Drugs are Developed: Basic Science, Lead Compound and Proof of Principle

- Pp. 87-116 (30)
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How New Drugs are Developed: Kinetics Evaluations

- Pp. 117-131 (15)
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How New Drugs are Developed: Toxicology

- Pp. 132-162 (31)
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How New Drugs are Developed: Improve the Lead Compound

- Pp. 163-176 (14)
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How New Drugs are Developed: Drug Delivery

- Pp. 177-187 (11)
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How New Drugs are Developed: Manufacturing and cGMP

- Pp. 188-238 (51)
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How New Drugs are Investigated

- Pp. 239-244 (6)
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Drugs that Inhibit Enzymes

- Pp. 245-287 (43)
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Drugs that Interact with Receptors and Ion Channels

- Pp. 288-316 (29)
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Drugs that Affect Transporters, Carriers and Ion Pumps

- Pp. 317-323 (7)
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Drugs that Act on Microtubules

- Pp. 324-328 (5)
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Drugs that Act on DNA or RNA

- Pp. 329-335 (7)
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Personalized Medicine and Targeted Drug Delivery

- Pp. 336-349 (14)
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Medicinal Chemistry and Biology of Cancer

- Pp. 350-377 (28)
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Metabolic Syndrome, Diabetes, Heart Disease and Stroke

- Pp. 378-398 (21)
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Infectious Diseases

- Pp. 399-413 (15)
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Biology of Inflammation

- Pp. 414-425 (12)
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Reproductive Medicine and Osteoporosis

- Pp. 426-435 (10)
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The Nervous System

- Pp. 436-480 (45)
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The Immune System and Immune Network

- Pp. 481-525 (45)
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Vaccines

- Pp. 526-537 (12)
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Preventing Diseases by Proper Nutrition

- Pp. 538-581 (44)
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Emergent Problems and Possible Solutions

- Pp. 582-598 (17)
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Biology of Information Flow, Receptors and Signaling

- Pp. 599-640 (42)
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Systems Biology, Autopoiesis, Network Theory

- Pp. 641-665 (25)
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Index

- Pp. 666-687 (22)
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