Topics in Anti-Cancer Research
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Editor: Atta-ur-Rahman / Khurshid Zaman

Topics in Anti-Cancer Research

Volume 2

eBook: US $129 Special Offer (PDF + Printed Copy): US $232
Printed Copy: US $168
Library License: US $516
ISSN: 2468-5860 (Print)
ISSN: 2213-3585 (Online)
ISBN: 978-1-60805-139-7 (Print)
ISBN: 978-1-60805-136-6 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080513661130201


This is the second volume of the Patent eBook Series titled Topics in Anti-Cancer Research. The eBook includes updated chapters on topics relevant to contemporary cancer research published in the journal, Recent Patents on Anti-Cancer Drug Discovery.

This volume covers scientific and patented novel chemotherapeutic agents and drugs for metastatic castration-resistant prostate cancer and Ras/ Raf /MEK/ERK pathway, P1K, AKT and mTORC1/2 inhibitors, ATPase inhibitors for cancer therapy, and sphingomyelin biosynthesis which regulates cancer cell death and growth.

Other chapters also explain research on biochemical regulation i.e. cell cycle and energy metabolism, the role of genetic variations of FcγRs gamma receptors in monoclonal antibody based anti-cancer therapy and effectiveness of antiangiogenic therapy, endogenous angiogenesis inhibitors and anti-angiogenic drugs for the treatment of renal cell carcinoma, prevention of cancer by ribonucleotide reductase, anticancer activity of Erlotinib in glioblastoma and the mechanisms of action of nanodrugs and nano-sized camptothecin drugs in cancer chemotherapy. The volume also covers recent studies in the field of onconutrition. The broad range of topics covered in this second volume will be of immense interest to clinicians, scientists and R&D experts seeking new targets for the prevention of cancer, novel oncogenic biomarkers, and methods for cancer therapy.

Indexed in: Book Citation Index, Science Edition, Chemical Abstracts, BIOSIS Previews, EBSCO, Ulrich's Periodicals Directory.


- Pp. i-iii (3)
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List of Contributors

- Pp. iv-v (2)
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- Pp. vi
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Emerging Research and Therapeutic Strategies for Castration-Resistant Prostate Cancer

- Pp. 3-34 (32)
Tomoaki Tanaka, Tatsuya Nakatani
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Sphingomyelin Biosynthesis Modulates Cancer Cell Death and Growth

- Pp. 35-62 (28)
Elodie Lafont, Kazuyuki Kitatani, Toshiro Okazaki, Bruno Ségui
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The Therapeutic Promise of Anti-Cancer Drugs Against the Ras/Raf/MEK/ERK Pathway

- Pp. 63-94 (32)
Erin K. Crane, Kwong-Kwok Wong
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Recent Developments in Anticancer Agents Targeting PI3K, AKT and mTORC1/2

- Pp. 95-196 (102)
Irene Brana, Sara De Dosso, Rodrigo Dienstmann, Jordi Rodon, Josep Tabernero, Ben Markman
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Cell Cycle and Energy Metabolism in Tumor Cells: Strategies for Drug Therapy

- Pp. 197-230 (34)
Nivea D. Amoêdo, Tatiana El-Bacha Porto, Mariana F. Rodrigues, Franklin D. Rumjanek
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V-ATPase Inhibitors in Cancer Therapy: Targeting Intraorganellar Acidification

- Pp. 231-256 (26)
Agustín Hernández, Gloria Serrano-Bueno, Rosana Herrera-Palau, José R. Pérez-Castiñeira, Aurelio Serrano
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Insights into the Role of Fc Gamma Receptors (FcγRs) Genetic Variations in Monoclonal Antibody-Based Anti-cancer Therapy

- Pp. 257-278 (22)
Fabio Concetti, Valerio Napolioni
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Angiogenesis: Therapeutic Target in Renal Cell Carcinoma

- Pp. 279-298 (20)
Manisha Singh, Sudip Nanda, Santo Longo, Shree G. Sharma
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Anti-Angiogenic Therapy for Cancer: Past, Present and Future

- Pp. 299-319 (21)
Boel De Paepe
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Paradigm Shift in the Therapeutic Potential of Endogenous Angiogenesis Inhibitors for Cancer Therapy: Historical Perspective and Future Direction

- Pp. 320-362 (43)
Mohanraj Dhanabal, Natarajan Sethuraman
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Ribonucleotide Reductase as a Target to Control Cancer Proliferation

- Pp. 363-406 (44)
Nuno M.F.S.A. Cerqueira, Narayana S.H.N. Moorthy, Pedro A. Fernandes, Maria J. Ramos
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Enhancing the Anticancer Activity of Erlotinib in Glioblastoma

- Pp. 407-436 (30)
Georg Karpel-Massler, Christian R. Wirtz, Marc-Eric Halatsch
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Nanodrugs: Magic Bullets in Cancer Chemotherapy

- Pp. 437-494 (58)
Kishwar Saleem, Waseem A. Wani, Ashanul Haque, Archana Milhotra, Imran Ali
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Chemotherapy of Nano-Sized Camptothecin-Derived Drugs

- Pp. 495-521 (27)
Nguyen-Van Cuong, Chi-Hui Guo, Ming-Fa Hsieh
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Onconutrition: Redox Chemoprevention by Functional Biomolecules and Biomarker Assessment

- Pp. 522-552 (31)
María D. Defagó, Elio A. Soria
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Author Index

- Pp. 553
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- Pp. 554-576 (23)
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.Alternative Remedies and Natural Products for Cancer Therapy: An Integrative Approach.
.The Management of Metastatic Triple-Negative Breast Cancer: An Integrated and Expeditionary Approach.
.Cancer Medicine in an Ayurvedic Perspective: A Critical Overview.
.Cancer Genes.